Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Volker Bigl"'
Autor:
David Ruiz-Carrillo, Hans-Ulrich Demuth, Steffen Roßner, Ulrike Zeitschel, Thomas Rudolph, Ingo Schulz, Volker Bigl, Bernd Gerhartz, Jens-Ulrich Rahfeld
Publikováno v:
Journal of Neurochemistry. 94:970-979
For a long time, prolyl endopeptidase (PEP) was believed to inactivate neuropeptides in the extracellular space. However, reports on the intracellular activity of PEP suggest additional, as yet unidentified, physiological functions for this enzyme. H
Autor:
Steffen Roßner, Hans-Ulrich Demuth, Ulrike Zeitschel, Reinhard Schliebs, Ingo Schulz, Volker Bigl
Publikováno v:
Neurochemical Research. 30:695-702
Prolyl endopeptidase (PEP) is believed to inactivate neuropeptides that are present in the extracellular space. However, the intracellular localization of PEP suggests additional, yet unidentified physiological functions for this enzyme. Here we stud
Autor:
Frank Gaunitz, Christine Lange-Dohna, Steffen Roßner, J. Regino Perez-Polo, Volker Bigl, Ulrike Zeitschel
Publikováno v:
Journal of Neuroscience Research. 73:73-80
The pathogenic processing of the amyloid precursor protein (APP) into β-amyloid peptides, which give rise to β-amyloid plaques in the brains of Alzheimer's disease patients, requires the enzymatic activity of the beta-site APP-cleaving enzyme 1 (BA
Publikováno v:
Neurochemical Research. 28:637-644
Alzheimer's disease (AD) is characterized, amongst others, by the appearance of vascular and parenchymal β-amyloid deposits in brain. Such aggregates are mainly composed of β-amyloid peptides, which are derived by proteolytic processing of a larger
Autor:
Heike Franke, Jenny Apelt, Ulrike Zeitschel, Ulrich Gärtner, Reinhard Schliebs, Volker Bigl, Albrecht Günther, Tobias Stahl, Steffen Roßner, Maike Hartlage-Rübsamen, Milena Penkowa
Publikováno v:
Glia. 41:169-179
The beta-site APP-cleaving enzyme (BACE1) is a prerequisite for the generation of β-amyloid peptides, which give rise to cerebrovascular and parenchymal β-amyloid deposits in the brain of Alzheimer's disease patients. BACE1 is neuronally expressed
Publikováno v:
Journal of Neurochemistry. 67:2573-2580
In the brain, all three isoenzyme types [muscle (M), liver (L), and brain (C)] of 6-phosphofructo-1-kinase (PFK ; EC 2.7.1.11) ) occur, forming a complex mixture of homo- and heterotetramers. The PFK isoenzyme pattern of the different brain cell type
Publikováno v:
Journal of Neurochemistry. 71:757-766
The pheochromocytoma PC12 cell line was used as a model system to characterize the role of the p75 neurotrophin receptor (p75 NTR ) and tyrosine kinase (Trk) A nerve growth factor (NGF) receptors on amyloid precursor protein (APP) expression and proc
Publikováno v:
Journal of Neuroscience Research. 64:437-446
We measured tissue distribution and expression pattern of the beta-site amyloid precursor protein (APP)-cleaving enzyme (BACE) in the brains of transgenic Tg2576 mice that show amyloid pathology. BACE protein was expressed at high levels in brain; at
Publikováno v:
International Journal of Developmental Neuroscience. 19:287-296
To elucidate the functional role of the amyloid precursor protein (APP) during brain ontogeny, developmental changes of APP levels in growth cones and synaptosomes were studied from embryonic day 14 up to postnatal day (PD) 400 using Western analysis
Publikováno v:
European Journal of Neuroscience. 13:1644-1648
We have recently shown that in utero treatment of guinea pigs with the DNA methylating substance methylazoxymethanol acetate (MAM) results in neocortical microencephalopathy, increased protein kinase C (PKC) activity and altered processing of the amy