Supramolecular aptamer nano-constructs for receptor-mediated targeting and light-triggered release of chemotherapeutics into cancer cells

Autor: Deepak K. Prusty, Volker Adam, Reza M. Zadegan, Stephan Irsen, Michael Famulok

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)

Effective therapeutic platforms should combine serum stability, selective targeting, and controlled drug release. Here, the authors self-assemble an aptamer-based nanoscaffold that contains separate cell-targeting and photo-regulated drug-carrying do

Externí odkaz: https://doaj.org/article/29b4ba7a1b2a46fe83630deece2fc4da

Nanobody-siRNA Conjugates for Targeted Delivery of siRNA to Cancer Cells

Autor: Mike W Helms, Sabine Scheidler, Volker Adam, Carlo Boutton, Bodo Brunner, Peter Casteels, Christiane Metz-Weidmann, Luciana Zimmermann, Pieter Deschaght, Matthias Ozog, Josefine Peterka, Kerstin Jahn-Hofmann, Timothy R. Wagenaar, Oleksandr Zavoiura

Publikováno v: Molecular pharmaceutics. 18(3)

Targeted extrahepatic delivery of siRNA remains a challenging task in the field of nucleic acid therapeutics. An ideal delivery tool must internalize siRNA exclusively into the cells of interest without affecting the silencing activity of siRNA. Here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87590d39a9b3f6da8a987a11426029e9
https://pubmed.ncbi.nlm.nih.gov/33444501

Expanding the toolbox of photoswitches for DNA nanotechnology using Arylazopyrazoles

Autor: Jeffrey S. Hannam, Volker Adam, Julián Valero, Mathias Centola, Deepak K. Prusty, Marko Škugor, Bernhard Klöckner, Michael Famulok

Publikováno v: Chemistry – A European Journal
Adam, V, Prusty, D K, Centola, M, Škugor, M, Hannam, J S, Valero Moreno, J, Klôckner, B & Famulok, M 2018, ' Expanding the Toolbox of Photoswitches for DNA Nanotechnology Using Arylazopyrazoles ', Chemistry-A European Journal, vol. 24, no. 5 . https://doi.org/10.1002/chem.201705500

Photoregulation is among the most promising tools for development of dynamic DNA nanosystems, due to its high spatiotemporal precision, biocompatibility, and ease of use. So far, azobenzene and its derivatives have shown high potential in photocontro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6948476f46864259c83e7fc41a9e3ee0
https://hdl.handle.net/21.11116/0000-0003-52F3-E21.11116/0000-0003-52F5-C

Effects of homoarginine supplementation on heart and skeletal muscle of rats with heart failure with preserved ejection fraction

Autor: Petra Büttner, Volker Adams, Sarah Werner, Susann Ossmann, Christian Besler, Edzard Schwedhelm, Holger Thiele

Publikováno v: ESC Heart Failure, Vol 9, Iss 6, Pp 4348-4351 (2022)

Abstract Aim Heart failure with preserved ejection fraction (HFpEF) is associated with left ventricular stiffness, impaired diastolic relaxation, and severe exercise intolerance. Decreased homoarginine (hArg) levels are an independent predictor of mo

Externí odkaz: https://doaj.org/article/d96e1e269c464c5f8ceaa01b1c9dc141

Peak O2‐pulse predicts exercise training‐induced changes in peak V̇O2 in heart failure with preserved ejection fraction

Autor: Stephan Mueller, Bernhard Haller, Anna Feuerstein, Ephraim B. Winzer, Paul Beckers, Mark J. Haykowsky, Andreas B. Gevaert, Jennifer Hommel, Luciene F. Azevedo, André Duvinage, Katrin Esefeld, Isabel Fegers‐Wustrow, Jeffrey W. Christle, Elisabeth Pieske‐Kraigher, Evgeny Belyavskiy, Daniel A. Morris, Martin Kropf, Radhakrishnan Aravind‐Kumar, Frank Edelmann, Axel Linke, Volker Adams, Emeline M. Van Craenenbroeck, Burkert Pieske, Martin Halle, the OptimEx‐Clin Study Group

Publikováno v: ESC Heart Failure, Vol 9, Iss 5, Pp 3393-3406 (2022)

Abstract Aims Exercise training (ET) has been consistently shown to increase peak oxygen consumption (V̇O2) in patients with heart failure with preserved ejection fraction (HFpEF); however, inter‐individual responses vary significantly. Because it

Externí odkaz: https://doaj.org/article/159531c046df4b9b9534243596bb7364