Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Volker A W, Kreye"'
Autor:
Rüdiger Becker, Johannes Greten, Christoph A. Karle, Sven Kathöfer, Jörg Kreuzer, Volker A. W. Kreye, Markus Alter, Claudia Kiesecker, Dierk Thomas, Hugo A. Katus, Edgar Zitron, Eberhard P. Scholz
Publikováno v:
Toxicology Letters. 165:156-166
Acute chloroform intoxication can cause depression of the central nervous system and may lead to death from lethal arrhythmias or respiratory arrest. Thus, the organic solvent is no longer in clinical use as an anaesthetic, but still plays a role in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d2555b3869c4ae60880bc563c743603
https://doi.org/10.1016/j.toxlet.2006.03.004
https://doi.org/10.1016/j.toxlet.2006.03.004
Autor:
Wolfgang Schoels, Claudia Kiesecker, Sven Kathöfer, Dierk Thomas, Johann Kiehn, Edgar Zitron, Sonja Lück, Christoph A. Karle, Hugo A. Katus, Volker A. W. Kreye, Eberhard P. Scholz
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 371:516-525
Flavonoids are naturally occurring food ingredients that have been associated with reduced cardiovascular mortality in epidemiological studies. In a previous study, we demonstrated for the first time that flavonoids are inhibitors of cardiac human et
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49725d4afe3ebb9ad7434fb0123ac490
https://doi.org/10.1007/s00210-005-1069-z
https://doi.org/10.1007/s00210-005-1069-z
Autor:
Konrad Brockmeier, Volker A. W. Kreye, Hugo A. Katus, Herbert E. Ulmer, Kezhong Wu, D. Thomas, Christoph A. Karle, Markus Khalil, Johann Kiehn, Michael Koenen, Joerg Zehelein, Wolfgang Schoels, Manuela Licka, Anna Britt Wimmer
Publikováno v:
Biochimica et Biophysica Acta
Romano-Ward syndrome (RWS), the autosomal dominant form of the congenital long QT syndrome, is characterised by prolongation of the cardiac repolarisation process associated with ventricular tachyarrhythmias of the torsades de pointes type. Genetic s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af4d0b0f746404c7196d1c248da555c1
Autor:
Dierk Thomas, Christoph A. Karle, Ramona Bloehs, Wolfgang Schoels, Volker A. W. Kreye, Hugo A. Katus, Sven Kathöfer, Eberhard P. Scholz, Sonja Lück, Johann Kiehn, Claudia Kiesecker, Edgar Zitron
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 370:423-435
Ajmaline is a class Ia anti-arrhythmic drug used in several European countries and Japan as first-line treatment for ventricular tachyarrhythmia. Ajmaline has been reported to induce cardiac output (QT) prolongation and to inhibit cardiac potassium c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3bb13741b88c42851bfb0a9bd3d9ba2
https://doi.org/10.1007/s00210-004-0976-8
https://doi.org/10.1007/s00210-004-0976-8
Autor:
Barbara A. Wible, Sven Kathöfer, Johann Kiehn, Dierk Thomas, Eckhard Ficker, Hugo A. Katus, Eberhard P. Scholz, Christoph A. Karle, Bettina C. Hammerling, Glenn E. Kirsch, Volker A. W. Kreye, Anna-Britt Wimmer, Mary C. Kochan, Edgar Zitron, Kezhong Wu, Wolfgang Schoels
Publikováno v:
British Journal of Pharmacology. 142:485-494
1 The topoisomerase II inhibitor amsacrine is used in the treatment of acute myelogenous leukemia. Although most anticancer drugs are believed not to cause acquired long QT syndrome (LQTS), concerns have been raised by reports of QT interval prolonga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15770883fbb943ee88f4e82836dfdb1f
https://doi.org/10.1038/sj.bjp.0705795
https://doi.org/10.1038/sj.bjp.0705795
Autor:
Sabine Höschele, Volker A. W. Kreye, Christoph A. Karle, Ralf Wodopia, Hugo A. Katus, Peter Bärtsch, Tobias Gehrig, Heimo Mairbäurl
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 286:L1154-L1160
In excitable cells, hypoxia inhibits K channels, causes membrane depolarization, and initiates complex adaptive mechanisms. It is unclear whether K channels of alveolar epithelial cells reveal a similar response to hypoxia. A549 cells were exposed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::589bcbc40e9ec2c8f282e652142842ea
https://doi.org/10.1152/ajplung.00403.2002
https://doi.org/10.1152/ajplung.00403.2002
Autor:
Johann Kiehn, Dierk Thomas, Christoph A. Karle, Wei Zhang, Wolfgang Schoels, Sven Kathöfer, Kezhong Wu, Hugo A. Katus, Edgar Zitron, Volker A. W. Kreye, Anna Britt Wimmer
Publikováno v:
British Journal of Pharmacology. 140:996-1002
Dronedarone is a noniodinated benzofuran derivative that has been synthesized to overcome the limiting iodine-associated adverse effects of the potent antiarrhythmic drug amiodarone. In this study, the acute electrophysiological effects of dronedaron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2128579fa4d9ab6dd23b7eddfe070b39
https://doi.org/10.1038/sj.bjp.0705502
https://doi.org/10.1038/sj.bjp.0705502
Autor:
Hugo A. Katus, Volker A. W. Kreye, Dierk Thomas, Katja Röckl, Wei Zhang, Johann Kiehn, Sven Kathöfer, Christoph A. Karle, Wolfgang Schoels
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 368:119-126
Modulation of the slow component of the delayed rectifier potassium current (IKs) in heart critically affects cardiac arrhythmogenesis. Its current amplitude is regulated by the sympathetic nervous system. However, the signal transduction from the be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22c7cee3c19bb8f6b82cd2bbd84efe9e
https://doi.org/10.1007/s00210-003-0772-x
https://doi.org/10.1007/s00210-003-0772-x
Autor:
Johann Kiehn, Gunnar Wendt-Nordahl, Wei Zhang, Kezhong Wu, Hugo A. Katus, Christoph A. Karle, Sven Kathöfer, Anna-Britt Wimmer, Bernd Gut, Dierk Thomas, Volker A. W. Kreye, Wolfgang Schoels
Publikováno v:
Cardiovascular Research. 59:14-26
Objective: Patients with HERG-associated long QT syndrome typically develop tachyarrhythmias during physical or emotional stress. Previous studies have revealed that activation of the beta-adrenergic system and consecutive elevation of the intracellu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c402a0c1dd2ad19f050e25edbdc1c84f
https://doi.org/10.1016/s0008-6363(03)00386-9
https://doi.org/10.1016/s0008-6363(03)00386-9
Autor:
Adel Abushi, Edgar Zitron, Volker A. W. Kreye, Wolfgang Schoels, Alexander Bauer, Slawomir Weretka, Christoph A. Karle
Publikováno v:
Basic Research in Cardiology. 97:17-25
Chromanol 293B and dofetilide are inhibitors of IKs and IKr, i.e., of the slow and the rapid component of the delayed rectifier potassium current. The specificity of these drugs was tested by investigating their effects on the delayed rectifier potas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f9b7294b1145e2805761d68ec86b1d7
https://doi.org/10.1007/s395-002-8383-9
https://doi.org/10.1007/s395-002-8383-9