Zobrazeno 1 - 10
of 226
pro vyhledávání: '"Volker, Nimmrich"'
Autor:
Marjoleen Nijsen, Wilfried Hornberger, Achim Moeller, Volker Nimmrich, Helmut Mack, Andreas Kling, Katja Jantos, Yanbin Lao
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:1968-1973
Aberrant activation of calpain has been observed in various pathophysiological disorders including neurodegenerative diseases such as Alzheimer's Disease. Here we describe our efforts on ketoamide-based 1-benzyl-5-oxopyrrolidine-2-carboxamides as a n
Autor:
Wilfried Hornberger, Achim Moeller, Yanbin Lao, Kennan C. Marsh, Karla Drescher, Wicke Karsten, Andreas Kling, Ana Lucia Relo, Volker Nimmrich, Charles W. Hutchins, Katja Jantos, Helmut Mack
Publikováno v:
Journal of Medicinal Chemistry. 60:7123-7138
Calpain overactivation has been implicated in a variety of pathological disorders including ischemia/reperfusion injury, cataract formation, and neurodegenerative diseases such as Alzheimer's disease (AD). Herein we describe our efforts leading to th
Autor:
Wicke Karsten, Volker Nimmrich, David Hermann, Claus Bruehl, Andreas Draguhn, Mario Mezler, Michaela K. Müller, Gerhard Gross
Publikováno v:
European Journal of Pharmacology. 702:44-55
Alzheimer's disease is accompanied by increased brain levels of soluble amyloid-β (Aβ) oligomers. It has been suggested that oligomers directly impair synaptic function, thereby causing cognitive deficits in Alzheimer's disease patients. Recently,
Publikováno v:
British Journal of Pharmacology. 165:1572-1583
BACKGROUND AND PURPOSE β-amyloid (Aβ) oligomers have been implicated in the early pathophysiology of Alzheimer's disease (AD). While the precise nature of the molecular target has not been fully revealed, a number of studies have indicated that Aβ
Autor:
M Strassburger, Gerhard Gross, Klaus G. Reymann, A Möller, Wicke Karsten, Volker Nimmrich, UH Schöder, Hans Schoemaker, A Hahn
Publikováno v:
British Journal of Pharmacology. 159:1523-1531
Background and purpose: Alzheimer's disease (AD) is a multifactorial, neurodegenerative disease, which is in part caused by an impairment of synaptic function, probably mediated by oligomeric forms of amyloid-β (Aβ). While the Aβ pathology mainly
Autor:
Volker Nimmrich, Ulrich Ebert
Publikováno v:
Reviews in the Neurosciences. 20:1-12
Since Alois Alzheimer first described morphological alterations associated with his patient's dementia more than 100 years ago, Alzheimer's disease (AD) was defined as neurodegenerative disease caused by extracellular deposits of misfolded proteins.
Autor:
Volker Nimmrich, Achim Möller, Ulrich H. Schröder, Paul G.M. Luiten, Gerhard Gross, Robert Szabo, Ivica Granic, Csaba Nyakas, Klaus G. Reymann, Hans Schoemaker, Wicke Karsten
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics, 327(2), 343-352. WILLIAMS & WILKINS
N-Methyl-D-aspartate( NMDA) receptor-mediated excitotoxicity is thought to underlie a variety of neurological disorders, and inhibition of either the NMDA receptor itself, or molecules of the intracellular cascade, may attenuate neurodegeneration in
Autor:
B. F. Cox, Gerard B. Fox, Volker Nimmrich, M. Schmidt, T. R. Seifert, Vincent P. Hradil, R.W. Loebbert, J. Harlan, R. Edalji, F. Luo
Publikováno v:
Neuroscience. 155:263-269
Neurovascular regulation, which is critical to the efficient functioning of the brain, is impaired in Alzheimer's disease and in transgenic mice overexpressing Abeta. Although senile plaques and neurofibrillary tangles represent neuropathological hal
Autor:
Lynne E. Rueter, Achim Moeller, Martin Schmidt, Volker Nimmrich, Min Zhang, Elizabeth van der Kam, Sean C. Turner, Junli Ma, Jordan W. Brown
Publikováno v:
Neuropharmacology. 101
The GABA(B) receptor has been indicated as a promising target for multiple CNS-related disorders. Baclofen, a prototypical orthosteric agonist, is used clinically for the treatment of spastic movement disorders, but is associated with unwanted side-e