Výsledky vyhledávání - "Volkan Yazar"

Akademický článek

Impaired ATF3 signaling involves SNAP25 in SOD1 mutant ALS patients

Autor: Volkan Yazar, Julia K. Kühlwein, Antje Knehr, Veselin Grozdanov, Arif B. Ekici, Albert C. Ludolph, Karin M. Danzer

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)

Abstract Epigenetic remodeling is emerging as a critical process for several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). Genetics alone fails to explain the etiology of ALS, the investigation of the epigenome might ther

Externí odkaz: https://doaj.org/article/fb52f08c0f9a400bb1d1d7e0a7c1a080

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Akademický článek

Gene network landscape of mouse splenocytes reveals integrin complex as the A151 ODN-responsive hub molecule in the immune transcriptome

Autor: Volkan Yazar, Ismail Cem Yilmaz, Artun Bulbul, Dennis M. Klinman, Ihsan Gursel

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 31, Iss , Pp 553-565 (2023)

Homeostatic restoration of an inflammatory response requires quenching of the immune system after pathogen threats vanish. A continued assault orchestrated by host defense results in tissue destruction or autoimmunity. A151 is the epitome of syntheti

Externí odkaz: https://doaj.org/article/b69edf08eb7d40f583c41e62c6e26e45

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Akademický článek

3D-MSCs A151 ODN-loaded exosomes are immunomodulatory and reveal a proteomic cargo that sustains wound resolution

Autor: Sérgio P. Camões, Ozlem Bulut, Volkan Yazar, Maria M. Gaspar, Sandra Simões, Rita Ferreira, Rui Vitorino, Jorge M. Santos, Ihsan Gursel, Joana P. Miranda

Publikováno v: Journal of Advanced Research, Vol 41, Iss , Pp 113-128 (2022)

Introduction: Non-healing wounds remain a major burden due to the lack of effective treatments. Mesenchymal stem cell-derived exosomes (MSC-Exo) have emerged as therapeutic options given their pro-regenerative and immunomodulatory features. Still, li

Externí odkaz: https://doaj.org/article/dc6d07a5a377457f891f656708724ed4

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Akademický článek

Integrative genome-wide analysis of dopaminergic neuron-specific PARIS expression in Drosophila dissects recognition of multiple PPAR-γ associated gene regulation

Autor: Volkan Yazar, Sung-Ung Kang, Shinwon Ha, Valina L. Dawson, Ted M. Dawson

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)

Abstract The transcriptional repressor called parkin interacting substrate (PARIS; ZNF746) was initially identified as a novel co-substrate of parkin and PINK1 that leads to Parkinson’s disease (PD) by disrupting mitochondrial biogenesis through pe

Externí odkaz: https://doaj.org/article/b3049af49e7a40df8697aa04359b1412

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DNA Methylation Signature of Aging: Potential Impact on the Pathogenesis of Parkinson’s Disease

Autor: Volkan Yazar, Valina L. Dawson, Ted M. Dawson, Sung-Ung Kang

Publikováno v: Journal of Parkinson's Disease. 13:145-164

Regulation of gene expression by epigenetic modifications means lasting and heritable changes in the function of genes without alterations in the DNA sequence. Of all epigenetic mechanisms identified thus far, DNA methylation has been of particular i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a790b1669c796f7145af38521f8b4d09
https://doi.org/10.3233/jpd-223517

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DNA Methylation Analysis in Monozygotic Twins Discordant for ALS in Blood Cells

Autor: Volkan Yazar, Wolfgang P Ruf, Antje Knehr, Kornelia Günther, Ole Ammerpohl, Karin M Danzer, Albert C Ludolph

Publikováno v: Epigenetics Insights 16, 251686572311721 (2023). doi:10.1177/25168657231172159

ALS is a fatal motor neuron disease that displays a broad variety of phenotypes ranging from early fatal courses to slowly progressing and rather benign courses. Such divergence can also be seen in genetic ALS cases with varying phenotypes bearing sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e10d28baf65e6f70afa59fe39534a61c
https://pub.dzne.de/record/257896

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Circulating extracellular vesicles of patients with steroid-sensitive nephrotic syndrome have higher RAC1 and induce recapitulation of nephrotic syndrome phenotype in podocytes

Autor: Ulku Guler, Muzaffer Yildirim, Volkan Yazar, Deniz Karakaya, Tugce Yildirim, Eda Çiftci Dede, Fehime Kara Eroglu, Ihsan Gursel, Tülin Güngör, Evra Çelikkaya, Nilsu Turay, Mehmet Bülbül, Petek Korkusuz, Bekir Salih

Publikováno v: American Journal of Physiology: Renal Physiology

Since previous research suggests a role of a circulating factor in the pathogenesis of steroid-sensitive nephrotic syndrome (NS), we speculated that circulating plasma extracellular vesicles (EVs) are a candidate source of such a soluble mediator. He

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd2c6a0ff9925c73a31e95c1999caf9d
https://doi.org/10.1152/ajprenal.00097.2021

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The Secretome of Human Neonatal Mesenchymal Stem Cells Modulates Doxorubicin-Induced Cytotoxicity: Impact in Non-Tumor Cells

Autor: Vera Marisa Costa, Nuno G. Oliveira, Matilde Castro, Bernardo Antunes, Volkan Yazar, Ana S. Serras, Joana P. Miranda, Fernando Remião, S.P. Camões, Flávio Dionísio, Rui Vitorino

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 13072
International Journal of Molecular Sciences, Vol 22, Iss 13072, p 13072 (2021)

Doxorubicin (Dox) is one of the most widely used treatments for breast cancer, although limited by the well-documented cardiotoxicity and other off-target effects. Mesenchymal stem cell (MSC) secretome has shown immunomodulatory and regenerative prop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16212c1eb8e1caae39e9bbfa97f5f011
http://europepmc.org/articles/PMC8657836

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