Translational derepression of Elavl4 isoforms at their alternative 5' UTRs determines neuronal development.

Autor: Popovitchenko T; Department of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School, Piscataway, NJ, 08854, USA.; Graduate Program in Neurosciences, Rutgers University, Piscataway, NJ, 08854, USA., Park Y; Department of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School, Piscataway, NJ, 08854, USA., Page NF; Department of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School, Piscataway, NJ, 08854, USA.; Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ, 08854, USA., Luo X; Department of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School, Piscataway, NJ, 08854, USA., Krsnik Z; Croatian Institute for Brain Research, Center of Research Excellence for Basic, Clinical and Translational Neuroscience, University of Zagreb, School of Medicine, Zagreb, 10000, Croatia., Liu Y; Department of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School, Piscataway, NJ, 08854, USA.; Graduate Program in Neurosciences, Rutgers University, Piscataway, NJ, 08854, USA., Salamon I; Department of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School, Piscataway, NJ, 08854, USA.; Graduate Program in Neurosciences, Rutgers University, Piscataway, NJ, 08854, USA.; Croatian Institute for Brain Research, Center of Research Excellence for Basic, Clinical and Translational Neuroscience, University of Zagreb, School of Medicine, Zagreb, 10000, Croatia., Stephenson JD; Department of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School, Piscataway, NJ, 08854, USA., Kraushar ML; Department of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School, Piscataway, NJ, 08854, USA.; Graduate Program in Neurosciences, Rutgers University, Piscataway, NJ, 08854, USA., Volk NL; Department of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School, Piscataway, NJ, 08854, USA., Patel SM; Department of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School, Piscataway, NJ, 08854, USA., Wijeratne HRS; Department of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School, Piscataway, NJ, 08854, USA., Li D; Department of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School, Piscataway, NJ, 08854, USA., Suthar KS; Department of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School, Piscataway, NJ, 08854, USA., Wach A; Department of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School, Piscataway, NJ, 08854, USA., Sun M; Department of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School, Piscataway, NJ, 08854, USA., Arnold SJ; Institute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, Signaling Research Centers BIOSS and CIBSS, University of Freiburg, Freiburg, D-79104, Germany., Akamatsu W; Department of Physiology, Keio University School of Medicine, Tokyo, 160-8582, Japan., Okano H; Department of Physiology, Keio University School of Medicine, Tokyo, 160-8582, Japan., Paillard L; Univ Rennes, CNRS, IGDR (Institut de génétique et développement de Rennes)-UMR 6290, F-35000, Rennes, France., Zhang H; Department of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School, Piscataway, NJ, 08854, USA., Buyske S; Department of Statistics, Rutgers University, Piscataway, NJ, 08854, USA., Kostovic I; Croatian Institute for Brain Research, Center of Research Excellence for Basic, Clinical and Translational Neuroscience, University of Zagreb, School of Medicine, Zagreb, 10000, Croatia., De Rubeis S; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Pl, New York, NY, 10029, USA.; Seaver Autism Center, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Hart RP; Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ, 08854, USA., Rasin MR; Department of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School, Piscataway, NJ, 08854, USA. roko.rasin@rutgers.edu.

Publikováno v: Nature communications [Nat Commun] 2020 Apr 03; Vol. 11 (1), pp. 1674. Date of Electronic Publication: 2020 Apr 03.