Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Vojtech Novohradsky"'
Autor:
Monika Hreusova, Vojtech Novohradsky, Lenka Markova, Hana Kostrhunova, Ivan Potočňák, Viktor Brabec, Jana Kasparkova
Publikováno v:
Bioinorganic Chemistry and Applications, Vol 2022 (2022)
In this work, gallium(III) complex with cloxyquin (5-chloro-8-quinolinol, HClQ) ligands is shown to effectively inhibit proliferation of rhabdomyosarcoma cells, the frequent, aggressive, and poorly treatable cancer of children. It offers striking sel
Externí odkaz:
https://doaj.org/article/9c53d497024647a2992bcd5d8fe8e554
Autor:
Jana Kasparkova, Hana Kostrhunova, Vojtech Novohradsky, Аlexey A. Logvinov, Viktor V. Temnov, Nataliya E. Borisova, Tatiana A. Podrugina, Lenka Markova, Pavel Starha, Alexey. A. Nazarov, Viktor Brabec
Publikováno v:
Bioinorganic Chemistry and Applications, Vol 2022 (2022)
One concept of improving anticancer effects of conventional platinum-based antitumor drugs consists of conjugating these compounds with other biologically (antitumor) active agents, acting by a different mechanism. Here, we present synthesis, physico
Externí odkaz:
https://doaj.org/article/3ca46adcbf094b3faac19d8bb49e9a33
Autor:
Vojtech Novohradsky, Ilaria Zanellato, Cristina Marzano, Jitka Pracharova, Jana Kasparkova, Dan Gibson, Valentina Gandin, Domenico Osella, Viktor Brabec
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract We present the anticancer properties of cis, cis, trans-[Pt(IV)(NH3)2Cl2(OA)2] [Pt(IV)diOA] (OA = octanoato), Pt(IV) derivative of cisplatin containing two OA units appended to the axial positions of a six-coordinate Pt(IV) center. Our resul
Externí odkaz:
https://doaj.org/article/8c8d7ac8a35249ac83c6856771eb6c7d
Publikováno v:
Nucleic Acids Research
The design of efficient and safe gene delivery vehicles remains a major challenge for the application of gene therapy. Of the many reported gene delivery systems, metal complexes with high affinity for nucleic acids are emerging as an attractive opti
Autor:
Vojtech Novohradsky, Lenka Markova, Hana Kostrhunova, Marie Svitelova, Jana Kasparkova, Alessandra Barbanente, Paride Papadia, Nicola Margiotta, James D. Hoeschele, Viktor Brabec
Publikováno v:
Inorganic Chemistry Frontiers. 9:3295-3305
Here, we investigated the mechanism of antiproliferative action in cancer cells of new compounds structurally derived from oxaliplatin, namely a pair of enantiomers [Pt(OXA)(1R,2R-DACHEX)] (1) and [Pt(OXA)(1S,2S-DACHEX)] (2) (OXA = oxalate, DACHEX =
Autor:
Jana Kasparkova, Hana Kostrhunova, Vojtech Novohradsky, Lili Ma, Guangyu Zhu, Elena R Milaeva, Alexender A Shtill, Robin Vinck, Gilles Gasser, Viktor Brabec, Alexey A Nazarov
Publikováno v:
Metallomics
Metallomics, Royal Society of Chemistry, 2022, ⟨10.1093/mtomcs/mfac048⟩
Metallomics, Royal Society of Chemistry, 2022, ⟨10.1093/mtomcs/mfac048⟩
This work studied the mechanism of action of a Pt(IV) complex 2 bearing two axial lonidamine ligands, which are selective inhibitors of aerobic glycolysis. The presence of two lonidamine ligands in 2 compared to the parent Pt(II) complex increased it
Autor:
Viktor Brabec, Natalia Cutillas, Hana Kostrhunova, Jana Kasparkova, Vojtech Novohradsky, José Ruiz, Gloria Vigueras, Alicia Marco, Lenka Markova
Publikováno v:
Inorganic Chemistry Frontiers. 8:4696-4711
Several anticancer chemotherapies, while eliminating the bulk of tumor cells, often fail, as they do not obliterate a small fraction of malignant cancer stem cells (CSCs). Thus, developing chemotherapeutics capable of targeting and abrogating CSCs, i
Autor:
Jakub Cervinka, Alberto Gobbo, Lorenzo Biancalana, Lenka Markova, Vojtech Novohradsky, Massimo Guelfi, Stefano Zacchini, Jana Kasparkova, Viktor Brabec, Fabio Marchetti
While ruthenium arene complexes have been widely investigated for their medicinal potential, studies on homologous compounds containing a tridentate tris(1-pyrazolyl)methane ligand are almost absent in the literature. Ruthenium(II) complex 1 was obta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dd17dcb4f17b7dfa42b651c08e935e6
https://hdl.handle.net/11585/897692
https://hdl.handle.net/11585/897692
Autor:
Hana Kostrhunova, Roger M. Phillips, Hannah E. Bridgewater, Samantha L. Shepherd, Simon J. Allison, Nicola J. Rogers, Viktor Brabec, Jana Kasparkova, Jitka Pracharova, Vojtech Novohradsky, Peter Scott, Hualong Song
Publikováno v:
Angewandte Chemie (International Ed. in English)
Monosaccharides are added to the hydrophilic face of a self‐assembled asymmetric FeII metallohelix, using CuAAC chemistry. The sixteen resulting architectures are water‐stable and optically pure, and exhibit improved antiproliferative selectivity
Autor:
Jitka Pracharova, Ondrej Hrabina, Hana Kostrhunova, Jaroslav Malina, Viktor Brabec, Peter Scott, Vojtech Novohradsky, Daniel H. Simpson, Nicola J. Rogers
Publikováno v:
Inorganic Chemistry. 59:3304-3311
The water-compatible optically pure metallohelices made by self-assembly of simple nonpeptidic organic components around Fe(II) ions are now recognized as a distinct subclass of helicates that exhibit similar architecture to some natural cationic ant