Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Vojtěch Pavluch"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-19 (2023)
Abstract Previously, a number of ~ 1.4 of mitochondrial DNA (mtDNA) molecules in a single nucleoid was reported, which would reflect a minimum nucleoid division. We applied 3D-double-color direct stochastic optical reconstruction microscopy (dSTORM),
Externí odkaz:
https://doaj.org/article/11d4c7119b4b4b58a18f60cf7ee25933
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Pancreatic-β-cell-specifying transcription factor Nkx6.1, indispensable for embryonic development of the pancreatic epithelium and commitment to β-cell lineage, directly controls the expression of a glucose transporter (Glut2), pyruvate ca
Externí odkaz:
https://doaj.org/article/242b49292f1641c19aed45be9d917bce
Autor:
Alberto Leguina-Ruzzi, Anežka Vodičková, Blanka Holendová, Vojtěch Pavluch, Jan Tauber, Hana Engstová, Andrea Dlasková, Petr Ježek
Publikováno v:
Biomolecules, Vol 10, Iss 7, p 1026 (2020)
Transcript levels for selected ATP synthase membrane FO-subunits—including DAPIT—in INS-1E cells were found to be sensitive to lowering glucose down from 11 mM, in which these cells are routinely cultured. Depending on conditions, the diminished
Externí odkaz:
https://doaj.org/article/b2d0e5d6348141e39c34cc0b14a77832
Background Previously, ~ 1.4 of mitochondrial DNA (mtDNA) molecules in a single nucleoid was reported. Such a minimum number would reflect a minimum nucloid division. Results We applied 3D-double-color direct stochastic optical reconstruction microsc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cb13675a45e168541a0c6a0a4d8f38a
https://doi.org/10.21203/rs.3.rs-2063370/v1
https://doi.org/10.21203/rs.3.rs-2063370/v1
Autor:
Zuzana Berková, Monika Cahova, Vojtěch Pavluch, Detlef Siemen, Ralf P. Brandes, Martin Jabůrek, Jan Tauber, Lydie Plecitá-Hlavatá, Blanka Holendová, Katrin Schröder, Petr Ježek
Publikováno v:
Diabetes. 69:1341-1354
NADPH facilitates glucose-stimulated insulin secretion (GSIS) in pancreatic islets (PIs) of β-cells through an as yet unknown mechanism. We found NADPH oxidase isoform 4 (NOX4) to be the main producer of cytosolic H2O2, which is essential for GSIS;
Autor:
Anežka Vodičková, Petr Ježek, Vojtěch Pavluch, Hana Engstová, Blanka Holendová, Jan Tauber, Andrea Dlasková, Alberto Leguina-Ruzzi
Publikováno v:
Biomolecules
Biomolecules, Vol 10, Iss 1026, p 1026 (2020)
Biomolecules; Volume 10; Issue 7; Pages: 1026
Biomolecules, Vol 10, Iss 1026, p 1026 (2020)
Biomolecules; Volume 10; Issue 7; Pages: 1026
Transcript levels for selected ATP synthase membrane FO-subunits—including DAPIT—in INS-1E cells were found to be sensitive to lowering glucose down from 11 mM, in which these cells are routinely cultured. Depending on conditions, the diminished
Autor:
Petr Ježek, Detlef Siemen, Ralf P. Brandes, Katrin Schroeder, Monika Cahová, Zuzana Berková, Vojtěch Pavluch, Jan Tauber, Blanka Holendová, Martin Jabůrek, Lydie Plecitá-Hlavatá, Ada Admin
NADPH facilitates glucose-stimulated insulin secretion (GSIS) in pancreatic islet (PI) b-cells by an as yet unknown mechanism. We found NADPH oxidase, isoform-4 (NOX4), to be the major producer of cytosolic H2O2, essential for GSIS, while the increas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::004cb0be56802ac602e8e81450aa64c2
https://doi.org/10.2337/db20-4567/suppl.12053772.v1
https://doi.org/10.2337/db20-4567/suppl.12053772.v1
Autor:
Lydie, Plecitá-Hlavatá, Martin, Jabůrek, Blanka, Holendová, Jan, Tauber, Vojtěch, Pavluch, Zuzana, Berková, Monika, Cahová, Katrin, Schröder, Ralf P, Brandes, Detlef, Siemen, Petr, Ježek
Publikováno v:
Diabetes. 69(7)
NADPH facilitates glucose-stimulated insulin secretion (GSIS) in pancreatic islets (PIs) of β-cells through an as yet unknown mechanism. We found NADPH oxidase isoform 4 (NOX4) to be the main producer of cytosolic H
Autor:
Petr Ježek, Lukáš Alán, Nikola Capková, Hana Engstová, Vojtěch Pavluch, Frantisek Saudek, Tomáš Špaček, Andrea Dlasková, Zuzana Berková
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Scientific Reports
Scientific Reports
Hypertrophic pancreatic islets (PI) of Goto Kakizaki (GK) diabetic rats contain a lower number of β-cells vs. non-diabetic Wistar rat PI. Remaining β-cells contain reduced mitochondrial (mt) DNA per nucleus (copy number), probably due to declining
Publikováno v:
The international journal of biochemistrycell biology. 106
The mitochondrion owns an autonomous genome. Double-stranded circular mitochondrial DNA (mtDNA) is organized in complexes with a packing/stabilizing transcription factor TFAM, having multiple roles, and proteins of gene expression machinery in struct