Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Vojtěch Škop"'
Autor:
Vojtěch Škop, Naili Liu, Cuiying Xiao, Emma Stinson, Kong Y. Chen, Kevin D. Hall, Paolo Piaggi, Oksana Gavrilova, Marc L. Reitman
Publikováno v:
Molecular Metabolism, Vol 84, Iss , Pp 101946- (2024)
Our circadian world shapes much of metabolic physiology. In mice ∼40% of the light and ∼80% of the dark phase time is characterized by bouts of increased energy expenditure (EE). These ultradian bouts have a higher body temperature (Tb) and therm
Externí odkaz:
https://doaj.org/article/623d031681324e7cb1d82d3498049f9d
The metabolic cost of physical activity in mice using a physiology-based model of energy expenditure
Autor:
Vojtěch Škop, Juen Guo, Naili Liu, Cuiying Xiao, Kevin D. Hall, Oksana Gavrilova, Marc L. Reitman
Publikováno v:
Molecular Metabolism, Vol 71, Iss , Pp 101699- (2023)
Objective: Physical activity is a major component of total energy expenditure (TEE) that exhibits extreme variability in mice. Our objective was to construct a general, physiology-based model of TEE to accurately quantify the energy cost of physical
Externí odkaz:
https://doaj.org/article/d9f14a2027ca4e2bb7aea70fef3138c6
Publikováno v:
Molecular Metabolism, Vol 53, Iss , Pp 101332- (2021)
Objective: To improve understanding of mouse energy homeostasis and its applicability to humans, we quantitated the effects of housing density on mouse thermal physiology in both sexes. Methods: Littermate wild type and Brs3-null mice were single- or
Externí odkaz:
https://doaj.org/article/176be1b4ce9843c9bc353b2310e14508
Autor:
Jaroslava Trnovská, Jan Šilhavý, Ondřej Kuda, Vladimír Landa, Václav Zídek, Petr Mlejnek, Miroslava Šimáková, Hynek Strnad, Vojtěch Škop, Olena Oliyarnyk, Ludmila Kazdová, Martin Haluzík, Michal Pravenec
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0179063 (2017)
Chronic low-grade inflammation plays an important role in the pathogenesis of insulin resistance. In the current study, we tested the effects of salsalate, a non-steroidal anti-inflammatory drug, in an animal model of inflammation and metabolic syndr
Externí odkaz:
https://doaj.org/article/8f616313fe6841dd9e8fec56bd41364a
Autor:
Hana Malínská, Olena Oliyarnyk, Vojtěch Škop, Jan Šilhavý, Vladimír Landa, Václav Zídek, Petr Mlejnek, Miroslava Šimáková, Hynek Strnad, Ludmila Kazdová, Michal Pravenec
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150924 (2016)
Inflammation and oxidative and dicarbonyl stress play important roles in the pathogenesis of type 2 diabetes. Metformin is the first-line drug of choice for the treatment of type 2 diabetes because it effectively suppresses gluconeogenesis in the liv
Externí odkaz:
https://doaj.org/article/e7088f4bdc484766897a5d24bbf99102
Autor:
Jan Šilhavý, Václav Zídek, Petr Mlejnek, Vladimír Landa, Miroslava Šimáková, Hynek Strnad, Olena Oliyarnyk, Vojtěch Škop, Ludmila Kazdová, Theodore Kurtz, Michal Pravenec
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e101906 (2014)
Inflammation and oxidative stress have been implicated in the pathogenesis of metabolic disturbances. Esters of fumaric acid, mainly dimethyl fumarate, exhibit immunomodulatory, anti-inflammatory, and anti-oxidative effects. In the current study, we
Externí odkaz:
https://doaj.org/article/b16d4dfa433643c6a5a87dd3b2f7e631
Autor:
Congjun Li, Allison S. Mogul, Oksana Gavrilova, Atreyi Saha, Vojtěch Škop, Cuiying Xiao, R. A. Pi ntildeol, Colleen K. Hadley, Marc L. Reitman, Haley S. Province, Michael J. Krashes
Publikováno v:
Cell metabolism. 33(7)
The preoptic area (POA) is a key region controlling body temperature (Tb), dictating thermogenic, cardiovascular, and behavioral responses to regulate Tb. Known POA neuronal populations reduce Tb when activated; a population that increases Tb upon ac
Autor:
Vojtěch Škop, Sebastian H. Zahler, Oksana Gavrilova, Ramón A. Piñol, Chia Li, Michael J. Krashes, Brandon K. Tan, Atreyi Saha, Cuiying Xiao, Marc L. Reitman
Publikováno v:
Nature neuroscience
Bombesin-like receptor 3 (BRS3) is an orphan G-protein-coupled receptor that regulates energy homeostasis and heart rate. We report that acute activation of Brs3-expressing neurons in the dorsomedial hypothalamus (DMHBrs3) increased body temperature
Autor:
Tereza Tykvartova, Matus Miklovic, Martin Kotrc, Petra Skaroupkova, Ludmila Kazdova, Jaroslava Trnovska, Vojtech Skop, Michal Kolar, Jiri Novotny, Vojtech Melenovsky
Publikováno v:
Pharmacology Research & Perspectives, Vol 12, Iss 1, Pp n/a-n/a (2024)
Abstract While phosphodiesterase‐5 inhibition (PED5i) may prevent hypertrophy and failure in pressure‐overloaded heart in an experimental model, the impact of PDE5i on volume‐overload (VO)‐induced hypertrophy is unknown. It is also unclear wh
Externí odkaz:
https://doaj.org/article/d062805e3709438687a940351a7af7a8
Autor:
Vojtěch Škop, Oksana Gavrilova, Cuiying Xiao, Naili Liu, Marc L. Reitman, Kevin D. Hall, Juen Guo
Publikováno v:
SSRN Electronic Journal.
The thermal physiology of humans and mice is radically different due to their 3000-fold difference in body size. In a cool environment, mice expend energy to maintain body temperature, while this is limited in adult humans. Here we map the mouse ther