Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Vojislav, Vukovic"'
Autor:
Mansoor N. Saleh, Manish R. Patel, Todd M. Bauer, Sanjay Goel, Gerald S. Falchook, Geoffrey I. Shapiro, Ki Y. Chung, Jeffrey R. Infante, Robert M. Conry, Guilherme Rabinowits, David S. Hong, Judy S. Wang, Ulrich Steidl, Loren D. Walensky, Gurudatta Naik, Vincent Guerlavais, Vojislav Vukovic, D. Allen Annis, Manuel Aivado, Funda Meric-Bernstam
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 27(19)
Purpose: We describe the first-in-human dose-escalation trial for ALRN-6924, a stabilized, cell-permeating peptide that disrupts p53 inhibition by mouse double minute 2 (MDM2) and MDMX to induce cell-cycle arrest or apoptosis in TP53-wild-type (WT) t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbbe63ad5994923a7c864f392c3bf857
https://pubmed.ncbi.nlm.nih.gov/35045962
https://pubmed.ncbi.nlm.nih.gov/35045962
Autor:
Mansoor N, Saleh, Manish R, Patel, Todd M, Bauer, Sanjay, Goel, Gerald S, Falchook, Geoffrey I, Shapiro, Ki Y, Chung, Jeffrey R, Infante, Robert M, Conry, Guilherme, Rabinowits, David S, Hong, Judy S, Wang, Ulrich, Steidl, Loren D, Walensky, Gurudatta, Naik, Vincent, Guerlavais, Vojislav, Vukovic, D Allen, Annis, Manuel, Aivado, Funda, Meric-Bernstam
Publikováno v:
Clinical Cancer Research. 28:429-429
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::190e87a46a24a131c3ec1ad1cb942f3b
https://doi.org/10.1158/1078-0432.ccr-21-4241
https://doi.org/10.1158/1078-0432.ccr-21-4241
Publikováno v:
Molecular Cancer Therapeutics. 20:P211-P211
Aim: We investigated whether p53 activation with ALRN-6924 can prevent toxicity in mouse models of acute radiation injury. Materials and methods: ALRN-6924 is a clinical-stage, first-in-class, stabilized cell-permeating alpha-helical peptide that dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fda8bbb9405de355db0003e011fb645a
https://doi.org/10.1158/1535-7163.targ-21-p211
https://doi.org/10.1158/1535-7163.targ-21-p211
Publikováno v:
Blood. 138:2947-2947
Background: Myelosuppression is a common sequela of acute radiation injury due to sensitivity of proliferating bone marrow cells to ionizing radiation. ALRN-6924 is a clinical-stage, first-in-class, stabilized cell-permeating alpha-helical peptide dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5136eecf888d12f88851cb8966983485
https://doi.org/10.1182/blood-2021-153206
https://doi.org/10.1182/blood-2021-153206
Publikováno v:
Experimental Hematology. 100:S61
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::918531fb66ed7e752cda372cfaec96e2
https://doi.org/10.1016/j.exphem.2021.12.258
https://doi.org/10.1016/j.exphem.2021.12.258
Autor:
Vojislav Vukovic, Manuel Aivado, Dean Pavlick, Lee A. Albacker, Garrett M. Frampton, D. Allen Annis
Publikováno v:
Journal of Clinical Oncology. 39:3124-3124
3124 Background: The p53 pathway is one of the most important in cancer biology, with mutation of the TP53 gene that encodes the p53 tumor suppressor protein observed in ≈50% of all cancers. We evaluated the frequency of changes in TP53 mutation st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f49fa6057c1c79deb50011763dba4b1
https://doi.org/10.1200/jco.2021.39.15_suppl.3124
https://doi.org/10.1200/jco.2021.39.15_suppl.3124
Autor:
A. Annis, Joseph McClanaghan, Luis A. Carvajal, Vojislav Vukovic, Manuel Aivado, Mariam Mounir, David Sutton, Vincent Guerlavais
Publikováno v:
Molecular Cancer Therapeutics. 18:C064-C064
Aim: We investigated whether p53 activation with ALRN-6924 can prevent or reduce chemotherapy-induced hematopoietic toxicity while preserving or enhancing anti-tumor efficacy of chemotherapy in p53-mutant tumors. Materials and methods: ALRN-6924 is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b76b354a15628747ee77451d9911c7e4
https://doi.org/10.1158/1535-7163.targ-19-c064
https://doi.org/10.1158/1535-7163.targ-19-c064
Expression of hypoxia-inducible factor-1α in cervical carcinomas: correlation with tumor oxygenation
Autor:
Hans Kristian Haugland, Anthony Fyles, Vojislav Vukovic, David W. Hedley, Melania Pintilie, Michael Milosevic, Richard P. Hill
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 53:854-861
To investigate the relations between hypoxia-inducible factor-1 (HIF-1), tumor oxygenation, and clinical correlates in patients with locally advanced carcinoma of the uterine cervix.Biopsies from 42 patients with invasive cervical carcinoma and previ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9593e0e16589d39a7035a13900ff002f
https://doi.org/10.1016/s0360-3016(02)02815-8
https://doi.org/10.1016/s0360-3016(02)02815-8
Publikováno v:
Radiotherapy and Oncology. 60:69-73
Background and Purpose : Recently we reported increased glutathione (GSH) levels in hypoxic regions of ME 180 and SiHa cervical cancer xenografts. Since this association might act synergistically to protect from radiotherapy, we examined the differen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abe16d4808ed3ad3697fdc6dacdf9a31
https://doi.org/10.1016/s0167-8140(01)00331-0
https://doi.org/10.1016/s0167-8140(01)00331-0
Publikováno v:
International journal of radiation oncology, biology, physics. 52(3)
Aberrant architecture of the tumor vasculature and temporal fluctuations in blood flow can result in tumor hypoxia. The aim of this study was to classify tumor hypoxia based on distance to blood vessels, and to characterize its biologic significance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e7e440b0350837a75f6311841431ae8
https://pubmed.ncbi.nlm.nih.gov/11849809
https://pubmed.ncbi.nlm.nih.gov/11849809