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Dimensional clinical phenotyping using post-mortem brain donor medical records: Association with neuropathology

Autor: Vogelgsang, Jonathan S., Dan, Shu, Lally, Anna P., Chatigny, Michael, Vempati, Sangeetha, Abston, Joshua, Durning, Peter T., Oakley, Derek H., McCoy, Thomas H., Klengel, Torsten, Berretta, Sabina

Publikováno v: bioRxiv

INTRODUCTIONTransdiagnostic dimensional phenotypes are essential to investigate the relationship between continuous symptom dimensions and pathological changes. This is a fundamental challenge to postmortem work, as assessment of newly developed phen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c85c5a8e482d09736a905d956f5786a
https://doi.org/10.1101/2023.05.04.539430

Concerted neuron-astrocyte gene expression declines in aging and schizophrenia.

Autor: Ling E; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA., Nemesh J; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA., Goldman M; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA., Kamitaki N; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA., Reed N; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA., Handsaker RE; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA., Genovese G; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA., Vogelgsang JS; McLean Hospital, Belmont, MA 02478, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA 02215, USA., Gerges S; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA., Kashin S; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA., Ghosh S; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA., Esposito JM; McLean Hospital, Belmont, MA 02478, USA., French K; McLean Hospital, Belmont, MA 02478, USA., Meyer D; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA., Lutservitz A; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA., Mullally CD; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA., Wysoker A; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA., Spina L; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA., Neumann A; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA., Hogan M; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA., Ichihara K; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA., Berretta S; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; McLean Hospital, Belmont, MA 02478, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA 02215, USA.; Program in Neuroscience, Harvard Medical School, Boston, MA 02215, USA., McCarroll SA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jan 08. Date of Electronic Publication: 2024 Jan 08.