Ferroptosis in health and disease.

Autor: Berndt C; Department of Neurology, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany., Alborzinia H; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM GGmbH), Heidelberg, Germany; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany., Amen VS; Rudolf Virchow Zentrum, Center for Integrative and Translational Bioimaging - University of Würzburg, Germany., Ayton S; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Australia., Barayeu U; Division of Redox Regulation, DKFZ-ZMBH Alliance, German Cancer Research Center (DKFZ) Heidelberg, Germany; Faculty of Biosciences, Heidelberg University, 69120, Heidelberg, Germany; Department of Environmental Medicine and Molecular Toxicology, Tohoku University Graduate School of Medicine, Sendai, Japan., Bartelt A; Institute for Cardiovascular Prevention (IPEK), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany; Institute for Diabetes and Cancer (IDC), Helmholtz Center Munich, Neuherberg, Germany; German Center for Cardiovascular Research, Partner Site Munich Heart Alliance, Munich, Germany., Bayir H; Department of Pediatrics, Columbia University, New York City, NY, USA., Bebber CM; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany; CECAD Cluster of Excellence, University of Cologne, Cologne, Germany., Birsoy K; Laboratory of Metabolic Regulation and Genetics, Rockefeller University, New York City, NY, USA., Böttcher JP; Institute of Molecular Immunology, School of Medicine, Technical University of Munich (TUM), Germany., Brabletz S; Department of Experimental Medicine 1, Nikolaus-Fiebiger Center for Molecular Medicine, Friedrich-Alexander University of Erlangen-Nürnberg, Germany., Brabletz T; Department of Experimental Medicine 1, Nikolaus-Fiebiger Center for Molecular Medicine, Friedrich-Alexander University of Erlangen-Nürnberg, Germany., Brown AR; Department of Biological Sciences, Columbia University, New York City, NY, USA., Brüne B; Institute of Biochemistry1-Pathobiochemistry, Goethe-Universität, Frankfurt Am Main, Germany., Bulli G; Department of Physiological Genomics, Ludwig-Maximilians-University, Munich, Germany., Bruneau A; Department of Hepatology and Gastroenterology, Charité - Universitätsmedizin Berlin, Campus Virchow-Klinikum (CVK) and Campus Charité Mitte (CCM), Berlin, Germany., Chen Q; College of Life Sciences, Nankai University, Tianjin, China., DeNicola GM; Department of Metabolism and Physiology, Moffitt Cancer Center, Tampa, FL, USA., Dick TP; Division of Redox Regulation, DKFZ-ZMBH Alliance, German Cancer Research Center (DKFZ) Heidelberg, Germany; Faculty of Biosciences, Heidelberg University, 69120, Heidelberg, Germany., Distéfano A; Instituto de Investigaciones Biológicas, CONICET, National University of Mar Del Plata, Argentina., Dixon SJ; Department of Biology, Stanford University, Stanford, CA, USA., Engler JB; Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Germany., Esser-von Bieren J; Department of Immunobiology, Université de Lausanne, Switzerland., Fedorova M; Center of Membrane Biochemistry and Lipid Research, University Hospital Carl Gustav Carus and Faculty of Medicine of TU Dresden, Germany., Friedmann Angeli JP; Rudolf Virchow Zentrum, Center for Integrative and Translational Bioimaging - University of Würzburg, Germany., Friese MA; Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Germany., Fuhrmann DC; Institute of Biochemistry1-Pathobiochemistry, Goethe-Universität, Frankfurt Am Main, Germany., García-Sáez AJ; Institute for Genetics, CECAD, University of Cologne, Germany; Max Planck Institute of Biophysics, Frankfurt/Main, Germany., Garbowicz K; Division of Neuroblastoma Genomics, DKFZ, Heidelberg, Germany., Götz M; Department of Physiological Genomics, Ludwig-Maximilians-University, Munich, Germany; Institute of Stem Cell Research, Helmholtz Center Munich, Germany., Gu W; Institute for Cancer Genetics, And Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA; Department of Pathology and Cell Biology, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA., Hammerich L; Department of Hepatology and Gastroenterology, Charité - Universitätsmedizin Berlin, Campus Virchow-Klinikum (CVK) and Campus Charité Mitte (CCM), Berlin, Germany., Hassannia B; Department of Biomedical Sciences, University of Antwerp, Belgium., Jiang X; Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York City, NY, USA., Jeridi A; Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Comprehensive Pneumology Center (CPC-M), Germany, Member of the German Center for Lung Research (DZL)., Kang YP; College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Republic of Korea., Kagan VE; School of Public Health, University of Pittsburgh, PA, USA., Konrad DB; Department of Pharmacy, Ludwig-Maximilians-University, Munich, Germany., Kotschi S; Institute for Cardiovascular Prevention (IPEK), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany., Lei P; State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China., Le Tertre M; Center for Translational Biomedical Iron Research, Heidelberg University, Germany., Lev S; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Liang D; Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York City, NY, USA., Linkermann A; Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Germany; Division of Nephrology, Department of Medicine, Albert Einstein College of Medicine, New York, NY, USA., Lohr C; Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany., Lorenz S; Institute of Metabolism and Cell Death, Helmholtz Center Munich, Germany., Luedde T; Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany., Methner A; Institute of Molecular Medicine, Johannes Gutenberg-Universität Mainz, Germany., Michalke B; Research Unit Analytical Biogeochemistry, Helmholtz Center Munich, Germany., Milton AV; Department of Pharmacy, Ludwig-Maximilians-University, Munich, Germany., Min J; School of Medicine, Zhejiang University, Hangzhou, China., Mishima E; Institute of Metabolism and Cell Death, Helmholtz Center Munich, Germany., Müller S; Cellular and Chemical Biology, Institut Curie, Paris, France., Motohashi H; Department of Gene Expression Regulation, Tohoku University, Sendai, Japan., Muckenthaler MU; Center for Translational Biomedical Iron Research, Heidelberg University, Germany., Murakami S; Department of Gene Expression Regulation, Tohoku University, Sendai, Japan., Olzmann JA; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA; Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA, USA; Chan Zuckerberg Biohub, San Francisco, CA, USA., Pagnussat G; Instituto de Investigaciones Biológicas, CONICET, National University of Mar Del Plata, Argentina., Pan Z; School of Life Sciences, Westlake University, Hangzhou, China., Papagiannakopoulos T; Department of Pathology, Grossman School of Medicine, New York University, NY, USA., Pedrera Puentes L; Institute for Genetics, CECAD, University of Cologne, Germany., Pratt DA; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Canada., Proneth B; Institute of Metabolism and Cell Death, Helmholtz Center Munich, Germany., Ramsauer L; Institute of Molecular Immunology, School of Medicine, Technical University of Munich (TUM), Germany., Rodriguez R; Cellular and Chemical Biology, Institut Curie, Paris, France., Saito Y; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan., Schmidt F; Institute of Molecular Medicine, Johannes Gutenberg-Universität Mainz, Germany., Schmitt C; Department of Pharmacy, Ludwig-Maximilians-University, Munich, Germany., Schulze A; Division of Tumour Metabolism and Microenvironment, DKFZ Heidelberg and DKFZ-ZMBH Alliance, Heidelberg, Germany., Schwab A; Department of Experimental Medicine 1, Nikolaus-Fiebiger Center for Molecular Medicine, Friedrich-Alexander University of Erlangen-Nürnberg, Germany., Schwantes A; Institute of Biochemistry1-Pathobiochemistry, Goethe-Universität, Frankfurt Am Main, Germany., Soula M; Laboratory of Metabolic Regulation and Genetics, Rockefeller University, New York City, NY, USA., Spitzlberger B; Department of Immunobiology, Université de Lausanne, Switzerland; Center of Allergy and Environment (ZAUM), Technical University of Munich and Helmholtz Center Munich, Munich, Germany., Stockwell BR; Department of Biological Sciences, Columbia University, New York City, NY, USA; Department of Pathology and Cell Biology, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA; Department of Chemistry, Columbia University, New York, NY, USA., Thewes L; Department of Neurology, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany., Thorn-Seshold O; Department of Pharmacy, Ludwig-Maximilians-University, Munich, Germany., Toyokuni S; Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Nagoya, Japan; Center for Low-temperature Plasma Sciences, Nagoya University, Nagoya, Japan; Center for Integrated Sciences of Low-temperature Plasma Core Research (iPlasma Core), Tokai National Higher Education and Research System, Nagoya, Japan., Tonnus W; Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Germany., Trumpp A; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM GGmbH), Heidelberg, Germany; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany., Vandenabeele P; VIB-UGent Center for Inflammation Research, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., Vanden Berghe T; Department of Biomedical Sciences, University of Antwerp, Belgium; VIB-UGent Center for Inflammation Research, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., Venkataramani V; Comprehensive Cancer Center Mainfranken, University Hospital Würzburg, Germany., Vogel FCE; Division of Tumour Metabolism and Microenvironment, DKFZ Heidelberg and DKFZ-ZMBH Alliance, Heidelberg, Germany., von Karstedt S; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany; CECAD Cluster of Excellence, University of Cologne, Cologne, Germany; University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Molecular Medicine Cologne, Germany., Wang F; School of Medicine, Zhejiang University, Hangzhou, China., Westermann F; Division of Neuroblastoma Genomics, DKFZ, Heidelberg, Germany., Wientjens C; Immunopathology Unit, Institute of Clinical Chemistry and Clinical Pharmacology, Medical Faculty, University Hospital Bonn, University of Bonn, Germany., Wilhelm C; Immunopathology Unit, Institute of Clinical Chemistry and Clinical Pharmacology, Medical Faculty, University Hospital Bonn, University of Bonn, Germany., Wölk M; Center of Membrane Biochemistry and Lipid Research, University Hospital Carl Gustav Carus and Faculty of Medicine of TU Dresden, Germany., Wu K; Department of Pathology, Grossman School of Medicine, New York University, NY, USA., Yang X; Institute for Cancer Genetics, And Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA., Yu F; College of Life Sciences, Nankai University, Tianjin, China., Zou Y; School of Life Sciences, Westlake University, Hangzhou, China; Westlake Four-Dimensional Dynamic Metabolomics (Meta4D) Laboratory, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China., Conrad M; Institute of Metabolism and Cell Death, Helmholtz Center Munich, Germany. Electronic address: marcus.conrad@helmholtz-muenchen.de.

Publikováno v: Redox biology [Redox Biol] 2024 Sep; Vol. 75, pp. 103211. Date of Electronic Publication: 2024 May 30.

Lipids as mediators of cancer progression and metastasis.

Autor: Vogel FCE; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany., Chaves-Filho AB; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany.; Institute of Chemistry, University of São Paulo, São Paulo, Brazil., Schulze A; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany. almut.schulze@dkfz-heidelberg.de.

Publikováno v: Nature cancer [Nat Cancer] 2024 Jan; Vol. 5 (1), pp. 16-29. Date of Electronic Publication: 2024 Jan 25.

LRP8-mediated selenocysteine uptake is a targetable vulnerability in MYCN-amplified neuroblastoma.

Autor: Alborzinia H; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM GmbH), Heidelberg, Germany.; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany., Chen Z; Rudolf Virchow Zentrum (RVZ), Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany., Yildiz U; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM GmbH), Heidelberg, Germany.; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.; European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany., Freitas FP; Rudolf Virchow Zentrum (RVZ), Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany., Vogel FCE; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany., Varga JP; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM GmbH), Heidelberg, Germany.; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.; European Molecular Biology Organization, Heidelberg, Germany., Batani J; Rudolf Virchow Zentrum (RVZ), Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany., Bartenhagen C; Center for Molecular Medicine Cologne (CMMC) and Department of Experimental Pediatric Oncology, University Children's Hospital, Medical Faculty, University of Cologne, Cologne, Germany., Schmitz W; Department of Biochemistry and Molecular Biology, Theodor Boveri Institute, Biocenter, University of Würzburg, Würzburg, Germany., Büchel G; Mildred Scheel Early Career Center, University Hospital Würzburg, Würzburg, Germany., Michalke B; Research Unit Analytical BioGeoChemistry, Helmholtz Center München (HMGU), Neuherberg, Germany., Zheng J; Institute of Metabolism and Cell Death, Helmholtz Zentrum München (HMGU), Neuherberg, Germany., Meierjohann S; Department of Pathology, University of Würzburg, Würzburg, Germany., Girardi E; CeMM-Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; Solgate GmbH, Klosterneuburg, Austria., Espinet E; Anatomy Unit, Department of Pathology and Experimental Therapy, School of Medicine, University of Barcelona (UB), L'Hospitalet de Llobregat, Barcelona, Spain.; Molecular Mechanisms and Experimental Therapy in Oncology Program (Oncobell), Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain., Flórez AF; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA., Dos Santos AF; Rudolf Virchow Zentrum (RVZ), Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany., Aroua N; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM GmbH), Heidelberg, Germany.; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany., Cheytan T; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM GmbH), Heidelberg, Germany.; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany., Haenlin J; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM GmbH), Heidelberg, Germany.; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany., Schlicker L; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany., Xavier da Silva TN; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany., Przybylla A; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM GmbH), Heidelberg, Germany.; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany., Zeisberger P; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM GmbH), Heidelberg, Germany.; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany., Superti-Furga G; CeMM-Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria., Eilers M; Department of Biochemistry and Molecular Biology, Theodor Boveri Institute, Biocenter, University of Würzburg, Würzburg, Germany., Conrad M; Institute of Metabolism and Cell Death, Helmholtz Zentrum München (HMGU), Neuherberg, Germany., Fabiano M; Institut für Biochemie und Molekularbiologie, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany., Schweizer U; Institut für Biochemie und Molekularbiologie, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany., Fischer M; Center for Molecular Medicine Cologne (CMMC) and Department of Experimental Pediatric Oncology, University Children's Hospital, Medical Faculty, University of Cologne, Cologne, Germany., Schulze A; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany., Trumpp A; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM GmbH), Heidelberg, Germany.; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany., Friedmann Angeli JP; Rudolf Virchow Zentrum (RVZ), Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany.

Publikováno v: EMBO molecular medicine [EMBO Mol Med] 2023 Aug 07; Vol. 15 (8), pp. e18014. Date of Electronic Publication: 2023 Jul 12.

Persister state-directed transitioning and vulnerability in melanoma.

Autor: Chauvistré H; Department of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen, Essen, Germany.; German Consortium for Translational Cancer Research (DKTK), Partner Site Essen/Düsseldorf, Essen/Düsseldorf, Germany., Shannan B; Department of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen, Essen, Germany.; German Consortium for Translational Cancer Research (DKTK), Partner Site Essen/Düsseldorf, Essen/Düsseldorf, Germany., Daignault-Mill SM; The University of Queensland Diamantina Institute, The University of Queensland, Brisbane, QLD, Australia., Ju RJ; The University of Queensland Diamantina Institute, The University of Queensland, Brisbane, QLD, Australia., Picard D; German Consortium for Translational Cancer Research (DKTK), Partner Site Essen/Düsseldorf, Essen/Düsseldorf, Germany.; Division of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology, and Clinical Immunology, Medical Faculty, University Hospital Düsseldorf, Düsseldorf, Germany.; Department of Neuropathology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany., Egetemaier S; Department of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen, Essen, Germany.; German Consortium for Translational Cancer Research (DKTK), Partner Site Essen/Düsseldorf, Essen/Düsseldorf, Germany., Váraljai R; Department of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen, Essen, Germany.; German Consortium for Translational Cancer Research (DKTK), Partner Site Essen/Düsseldorf, Essen/Düsseldorf, Germany., Gibhardt CS; Molecular Physiology, Institute of Cardiovascular Physiology, University Medical Center, Georg-August-University, Göttingen, Germany., Sechi A; Institute for Biomedical Engineering, Department of Cell Biology, RWTH Aachen University Medical School, Aachen, Germany., Kaschani F; Department of Chemical Biology, Faculty of Biology, University of Duisburg-Essen, Essen, Germany.; Center for Medical Biotechnology (ZMB), University of Duisburg-Essen, Essen, Germany., Keminer O; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Schnackenburgallee 114, 22525, Hamburg, Germany.; Fraunhofer Cluster of Excellence for Immune-Mediated Diseases CIMD, Schnackenburgallee 114, 22525, Hamburg, Germany., Stehbens SJ; The University of Queensland Diamantina Institute, The University of Queensland, Brisbane, QLD, Australia., Liu Q; The Wistar Institute, Philadelphia, PA, USA., Yin X; The Wistar Institute, Philadelphia, PA, USA., Jeyakumar K; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Strasse 4a, 44227, Dortmund, Germany., Vogel FCE; Department of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen, Essen, Germany.; German Consortium for Translational Cancer Research (DKTK), Partner Site Essen/Düsseldorf, Essen/Düsseldorf, Germany.; Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany., Krepler C; The Wistar Institute, Philadelphia, PA, USA., Rebecca VW; The Wistar Institute, Philadelphia, PA, USA., Kubat L; German Consortium for Translational Cancer Research (DKTK), Partner Site Essen/Düsseldorf, Essen/Düsseldorf, Germany.; Translational Skin Cancer Research (TSCR), German Cancer Consortium (DKTK), University Hospital of Essen, Universitätsstrasse 1, 45141, Essen, Germany., Lueong SS; German Consortium for Translational Cancer Research (DKTK), Partner Site Essen/Düsseldorf, Essen/Düsseldorf, Germany.; Institute for Developmental Cancer Therapeutics, West German Cancer Center, University Hospital Essen, 45122, Essen, Germany., Forster J; German Consortium for Translational Cancer Research (DKTK), Partner Site Essen/Düsseldorf, Essen/Düsseldorf, Germany.; Department of Human Genetics, University Hospital Essen, University Duisburg-Essen, Hufelandstrasse 55, 45122, Essen, Germany., Horn S; Department of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen, Essen, Germany.; German Consortium for Translational Cancer Research (DKTK), Partner Site Essen/Düsseldorf, Essen/Düsseldorf, Germany., Remke M; German Consortium for Translational Cancer Research (DKTK), Partner Site Essen/Düsseldorf, Essen/Düsseldorf, Germany.; Division of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology, and Clinical Immunology, Medical Faculty, University Hospital Düsseldorf, Düsseldorf, Germany.; Department of Neuropathology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany., Ehrmann M; Center for Medical Biotechnology (ZMB), University of Duisburg-Essen, Essen, Germany.; Department of Microbiology, University of Duisburg-Essen, Universitätsstraße 2, 45117, Essen, Germany., Paschen A; Department of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen, Essen, Germany.; German Consortium for Translational Cancer Research (DKTK), Partner Site Essen/Düsseldorf, Essen/Düsseldorf, Germany., Becker JC; Department of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen, Essen, Germany.; German Consortium for Translational Cancer Research (DKTK), Partner Site Essen/Düsseldorf, Essen/Düsseldorf, Germany.; Translational Skin Cancer Research (TSCR), German Cancer Consortium (DKTK), University Hospital of Essen, Universitätsstrasse 1, 45141, Essen, Germany., Helfrich I; Department of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen, Essen, Germany.; German Consortium for Translational Cancer Research (DKTK), Partner Site Essen/Düsseldorf, Essen/Düsseldorf, Germany., Rauh D; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Strasse 4a, 44227, Dortmund, Germany., Kaiser M; Department of Chemical Biology, Faculty of Biology, University of Duisburg-Essen, Essen, Germany.; Center for Medical Biotechnology (ZMB), University of Duisburg-Essen, Essen, Germany., Gul S; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Schnackenburgallee 114, 22525, Hamburg, Germany.; Fraunhofer Cluster of Excellence for Immune-Mediated Diseases CIMD, Schnackenburgallee 114, 22525, Hamburg, Germany., Herlyn M; The Wistar Institute, Philadelphia, PA, USA., Bogeski I; Molecular Physiology, Institute of Cardiovascular Physiology, University Medical Center, Georg-August-University, Göttingen, Germany., Rodríguez-López JN; GENZ-Group of Research on Enzymology, Department of Biochemistry and Molecular Biology-A, Regional Campus of International Excellence 'Campus Mare Nostrum', University of Murcia, Murcia, Spain., Haass NK; The University of Queensland Diamantina Institute, The University of Queensland, Brisbane, QLD, Australia., Schadendorf D; Department of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen, Essen, Germany.; German Consortium for Translational Cancer Research (DKTK), Partner Site Essen/Düsseldorf, Essen/Düsseldorf, Germany.; Center for Medical Biotechnology (ZMB), University of Duisburg-Essen, Essen, Germany., Roesch A; Department of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen, Essen, Germany. alexander.roesch@uk-essen.de.; German Consortium for Translational Cancer Research (DKTK), Partner Site Essen/Düsseldorf, Essen/Düsseldorf, Germany. alexander.roesch@uk-essen.de.; Center for Medical Biotechnology (ZMB), University of Duisburg-Essen, Essen, Germany. alexander.roesch@uk-essen.de.

Publikováno v: Nature communications [Nat Commun] 2022 Jun 01; Vol. 13 (1), pp. 3055. Date of Electronic Publication: 2022 Jun 01.

Zelkovamycin is an OXPHOS Inhibitory Member of the Argyrin Natural Product Family.

Autor: Krahn D; Chemische Biologie, Universität Duisburg-Essen, ZMB, Fakultät für Biologie, Universitätsstr. 2, 45117, Essen, Germany., Heilmann G; Chemische Biologie, Universität Duisburg-Essen, ZMB, Fakultät für Biologie, Universitätsstr. 2, 45117, Essen, Germany., Vogel FCE; Department of Dermatology, University hospital Essen, West German Cancer Center, University Duisburg-Essen and the German Cancer Consortium (DKTK).; Current address: Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany., Papadopoulos C; Molekularbiologie I, Universität Duisburg-Essen, ZMB, Fakultät für Biologie, Universitätsstr. 2, 45117, Essen, Germany., Zweerink S; Chemische Biologie, Universität Duisburg-Essen, ZMB, Fakultät für Biologie, Universitätsstr. 2, 45117, Essen, Germany.; Current address: University of Cologne, Faculty of Medicine and University Hospital of Cologne, Department of Gastroenterology and Hepatology, Kerpener Str. 62, 50937, Cologne, Germany., Kaschani F; Chemische Biologie, Universität Duisburg-Essen, ZMB, Fakultät für Biologie, Universitätsstr. 2, 45117, Essen, Germany., Meyer H; Molekularbiologie I, Universität Duisburg-Essen, ZMB, Fakultät für Biologie, Universitätsstr. 2, 45117, Essen, Germany., Roesch A; Department of Dermatology, University hospital Essen, West German Cancer Center, University Duisburg-Essen and the German Cancer Consortium (DKTK)., Kaiser M; Chemische Biologie, Universität Duisburg-Essen, ZMB, Fakultät für Biologie, Universitätsstr. 2, 45117, Essen, Germany.

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2020 Jul 14; Vol. 26 (39), pp. 8524-8531. Date of Electronic Publication: 2020 Jun 17.