Human Purkinje in silico model enables mechanistic investigations into automaticity and pro-arrhythmic abnormalities

Autor: Norbert Nagy, Najah Abi-Gerges, Stefano Severi, Blanca Rodriguez, Elisa Passini, András Varró, Cristian Trovato

Publikováno v: Journal of Molecular and Cellular Cardiology

Cardiac Purkinje cells (PCs) are implicated in lethal arrhythmias caused by cardiac diseases, mutations, and drug action. However, the pro-arrhythmic mechanisms in PCs are not entirely understood, particularly in humans, as most investigations are co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b9d4211eea80d196c26a9c6d2e9b4a4
https://pubmed.ncbi.nlm.nih.gov/32251669

Beta-cell hubs maintain Ca

Autor: Chon-Lok, Lei, Joely A, Kellard, Manami, Hara, James D, Johnson, Blanca, Rodriguez, Linford J B, Briant

Publikováno v: Islets

Islet β-cells are responsible for secreting all circulating insulin in response to rising plasma glucose concentrations. These cells are a phenotypically diverse population that express great functional heterogeneity. In mice, certain β-cells (term

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e65485871fe522b5e9e6a58dd8205755
https://pubmed.ncbi.nlm.nih.gov/30142036

Acoustic over-exposure triggers burst firing in dorsal cochlear nucleus fusiform cells

Autor: Martine Hamann, Charles H. Large, Ian D. Forsythe, Nadia Pilati

Publikováno v: Hearing Research

Acoustic over-exposure (AOE) triggers deafness in animals and humans and provokes auditory nerve degeneration. Weeks after exposure there is an increase in the cellular excitability within the dorsal cochlear nucleus (DCN) and this is considered as a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89865771f017e13c3bfd0174d645bc4f
https://doi.org/10.1016/j.heares.2011.10.008

Beta-cell hubs maintain Ca ²⁺ oscillations in human and mouse islet simulations.

Autor: Lei CL; a Doctoral Training Centre , University of Oxford , Oxford , UK.; b Department of Computer Science , University of Oxford , Oxford , UK., Kellard JA; c Oxford Centre for Diabetes, Endocrinology, and Metabolism, Radcliffe Department of Medicine , University of Oxford, Churchill Hospital , Oxford , UK., Hara M; d Department of Medicine , The University of Chicago , Chicago , USA., Johnson JD; e Department of Cellular and Physiological Sciences, Diabetes Research Group , Life Sciences Institute, University of British Columbia , Vancouver , Canada., Rodriguez B; b Department of Computer Science , University of Oxford , Oxford , UK., Briant LJB; b Department of Computer Science , University of Oxford , Oxford , UK.; c Oxford Centre for Diabetes, Endocrinology, and Metabolism, Radcliffe Department of Medicine , University of Oxford, Churchill Hospital , Oxford , UK.

Publikováno v: Islets [Islets] 2018; Vol. 10 (4), pp. 151-167.

Kir4.1-mediated spatial buffering of K(+): experimental challenges in determination of its temporal and quantitative contribution to K(+) clearance in the brain.

Autor: Larsen BR; a Department of Cellular and Molecular Medicine; Faculty of Health and Medical Sciences ; University of Copenhagen ; Copenhagen , Denmark., MacAulay N

Publikováno v: Channels (Austin, Tex.) [Channels (Austin)] 2014; Vol. 8 (6), pp. 544-50.