Characterization of triptolide-induced hepatotoxicity by imaging and transcriptomics in a novel zebrafish model

Autor: Vliegenthart, Bastiaan, Wei, Chunmin, Buckley, Charlotte, Berends, Cécile, de Potter, Carmelita, Schneemann, Sarah, Del-Pozo, Jorge, Tucker, Carl, Mullins, John, Webb, David, Dear, James

Publikováno v: Vliegenthart, B, Wei, C, Buckley, C, Berends, C, de Potter, C, Schneemann, S, Del-Pozo, J, Tucker, C, Mullins, J, Webb, D & Dear, J 2017, ' Characterization of triptolide-induced hepatotoxicity by imaging and transcriptomics in a novel zebrafish model ', Toxicological Sciences, vol. 159, no. 2, pp. 380-391 . https://doi.org/10.1093/toxsci/kfx144

Triptolide is a vine extract used in traditional Chinese medicines and associated with hepatotoxicity. In vitro data suggest that inhibition of RNA synthesis may be the mechanism of toxicity. For studying drug-induced liver injury the zebrafish has e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3094::ed29b9ca36f6f8775b5d05b087856457
https://www.pure.ed.ac.uk/ws/files/41257052/kfx144.pdf

The effect of renal dysfunction and haemodialysis on circulating liver specific miR-122

Autor: Rivoli, Laura, Vliegenthart, Bastiaan, de Potter, Carmelita, van Bragt, Job, Tzoumas, Nikolaos, Gallacher, Peter, Farrah, Tariq, Dhaun, Neeraj, Dear, James

Publikováno v: Rivoli, L, Vliegenthart, B, de Potter, C, van Bragt, J, Tzoumas, N, Gallacher, P, Farrah, T, Dhaun, N & Dear, J 2016, ' The effect of renal dysfunction and haemodialysis on circulating liver specific miR-122 ', British Journal of Clinical Pharmacology . https://doi.org/10.1111/bcp.13136

AimmicroRNA-122 (miR-122) is a hepatotoxicity biomarker with utility in the management of paracetamol overdose and in drug development. Renal dysfunction and haemodialysis have been associated with a reduction in circulating microRNA. The objective o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3094::16a78c13cbbab42b59a7911b5f3b82ec
https://www.pure.ed.ac.uk/ws/files/27891729/MicroRNA_122_and_ESRD_Paper_V3_no_mark_up.docx

Circulating microRNA profiles in human drug-induced liver injury

Autor: Vliegenthart, Bastiaan, Shaffer, Jonathan, Peeters, Laura, Webb, David, Bateman, Nick, Bailey, Matthew, Craig, Darren, Simpson, Ken, Lader, Eric, Dear, James

Publikováno v: In Toxicology Letters 10 September 2014 229 Supplement:S94-S94

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