Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Vladlen G. Klochkov"'
Autor:
Natalia A. Lozinskaya, Elena N. Bezsonova, Meriam Dubar, Daria D. Melekhina, Daniil R. Bazanov, Alexander S. Bunev, Olga B. Grigor’eva, Vladlen G. Klochkov, Elena V. Sokolova, Denis A. Babkov, Alexander A. Spasov, Sergey E. Sosonyuk
Publikováno v:
Molecules, Vol 28, Iss 3, p 1174 (2023)
The enzyme NRH:quinone oxidoreductase 2 (NQO2) plays an important role in the pathogenesis of various diseases such as neurodegenerative disorders, malaria, glaucoma, COVID-19 and cancer. NQO2 expression is known to be increased in some cancer cell l
Externí odkaz:
https://doaj.org/article/f853fec7228a4d49b587ac47a06f585a
Autor:
Dmitriy V. Maltsev, Maria O. Skripka, Alexander A. Spasov, Pavel M. Vassiliev, Maxim A. Perfiliev, Lyudmila N. Divaeva, Alexander A. Zubenko, Anatolii S. Morkovnik, Alexander I. Klimenko, Mikhail V. Miroshnikov, Vladlen G. Klochkov, Laura R. Ianalieva
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 22, p 14401 (2022)
A new series of quinoxaline derivatives, 2a–4b, were synthesized and their anxiolytic potential was evaluated in vivo using elevated plus maze (EPM), open field (OF) and light-dark box (LDB) techniques. According to the results of the EPM, four act
Externí odkaz:
https://doaj.org/article/02ad0281428f437c8ec53e32ca640348
Autor:
Alexander A. Spasov, Pavel M. Vassiliev, Darya Merezhkina, V. A. Kosolapov, Viktor Sirotenko, R. A. Litvinov, M. V. Miroshnikov, Alexander Ozerov, Denis A. Babkov, N. A. Gurova, Alena Taran, Vladlen G. Klochkov, A. V. Borisov, Natalia Ovsyankina
The Na+/H+ exchanger isoform 1 (NHE-1) attracts ongoing attention as a validated drug target for the management of cardiovascular and ocular diseases owing to cytoprotective, anti-ischemic and anti-inflammatory properties of NHE-1 inhibitors. Herein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f18189481f81b5cbd4810acae79acaa6
https://doi.org/10.21203/rs.3.rs-877643/v1
https://doi.org/10.21203/rs.3.rs-877643/v1
Autor:
Denis A. Babkov, Ekaterina V. Zaryanova, Alexander A. Spasov, N. A. Lozinskaya, Meriam Dubar, Daria D. Melekhina, V. V. Temnov, E.N. Bezsonova, Vladlen G. Klochkov
Publikováno v:
Bioorganicmedicinal chemistry letters. 55
Type 2 diabetes mellitus is a chronic progressive disease that usually requires polypharmacological treatment approaches. Previously we have described a series of 2-oxindole derivatives as GSK3β inhibitors with in vivo antihyperglycemic activity. α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48afc05cbadda552e6f4a911b5e240af
https://pubmed.ncbi.nlm.nih.gov/34780899
https://pubmed.ncbi.nlm.nih.gov/34780899
Publikováno v:
Journal of Volgograd State Medical University. 15:133-138
For 14 main nodes of the RAGE-NF-kB signaling pathway 34 types of monofunctional proteins, subunits and isoforms have been identified that are related to the development of pathies in diabetes mellitus and Alzheimer's disease. For human, 583 experime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1170ff836f75dd26995fa4f6c6244db8
https://doi.org/10.19163/1994-9480-2018-3(67)-133-138
https://doi.org/10.19163/1994-9480-2018-3(67)-133-138
Autor:
D. T. Appazova, L. R. Yanaliyeva, Pavel M. Vassiliev, A. N. Kochetkov, Vladlen G. Klochkov, V. V. Vorfolomeyeva, Alexander A. Spasov
Publikováno v:
Biomeditsinskaia khimiia. 65(2)
Based on the methodology of artificial neural networks, models describing the dependence of the level of RAGE inhibitory activity on the affinity of compounds for target proteins of the RAGE-NF-kB signal pathway have been costructed. A validated data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9130f89c80a492f8132c241252c0acab
https://pubmed.ncbi.nlm.nih.gov/30950813
https://pubmed.ncbi.nlm.nih.gov/30950813
Autor:
Dmitry V. Osipov, Vladlen G. Klochkov, Maxim R. Demidov, Denis A. Babkov, Alexander A. Spasov, Yuri N. Klimochkin, Vitaly A. Osyanin, Diana R. Prilepskaya
Publikováno v:
Bioorganicmedicinal chemistry letters. 29(1)
Herein we report a study of novel arylchromene derivatives as analogs of naturally occurring flavonoids with prominent α-glucosidase inhibitory properties. Novel inhibitors were identified via simple stepwise in silico screening, efficient synthesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::877acea247cc47c67c07ccfda93058b2
https://pubmed.ncbi.nlm.nih.gov/30340897
https://pubmed.ncbi.nlm.nih.gov/30340897