Zobrazeno 1 - 10 of 17 pro vyhledávání: '"Vladislav Uzunangelov"'
1
Akademický článek
Accurate cancer phenotype prediction with AKLIMATE, a stacked kernel learner integrating multimodal genomic data and pathway knowledge.
Autor: Vladislav Uzunangelov, Christopher K Wong, Joshua M Stuart
Publikováno v: PLoS Computational Biology, Vol 17, Iss 4, p e1008878 (2021)
Advancements in sequencing have led to the proliferation of multi-omic profiles of human cells under different conditions and perturbations. In addition, many databases have amassed information about pathways and gene "signatures"-patterns of gene ex
Externí odkaz: https://doaj.org/article/6f69edcd31c5403fa6672de66cc7316e
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2
Akademický článek
Allocating HIV prevention funds in the United States: recommendations from an optimization model.
Autor: Arielle Lasry, Stephanie L Sansom, Katherine A Hicks, Vladislav Uzunangelov
Publikováno v: PLoS ONE, Vol 7, Iss 6, p e37545 (2012)
The Centers for Disease Control and Prevention (CDC) had an annual budget of approximately $327 million to fund health departments and community-based organizations for core HIV testing and prevention programs domestically between 2001 and 2006. Annu
Externí odkaz: https://doaj.org/article/3526a2b933ae4d71b493560d83edc28e
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3
Highly Accurate Cancer Phenotype Prediction with AKLIMATE, a Stacked Kernel Learner Integrating Multimodal Genomic Data and Pathway Knowledge
Autor: Vladislav Uzunangelov, Christopher K. Wong, Josh Stuart
Advancements in sequencing have led to the proliferation of multi-omic profiles of human cells under different conditions and perturbations. In addition, several databases have amassed information about pathways and gene “signatures” – patterns
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6af0e48a21f4c643ef05ab98ee508563
https://doi.org/10.1101/2020.07.15.205575
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4
MEK-ERK signaling is a therapeutic target in metastatic castration resistant prostate cancer
Autor: Elad Neeman, Adam Foye, Eric J. Small, Lauren E. Howard, Josh Stuart, William J. Aronson, Allen C. Gao, Jiaoti Huang, Zheng Xia, Felix Y. Feng, Rahul Aggarwal, George Thomas, Robert Baertsch, Christopher P. Evans, Vladislav Uzunangelov, Nicholas G. Nickols, Amanda De Hoedt, Ramin Nazarian, Tomasz M. Beer, Shuang G. Zhao, Justin M. Drake, Robert E. Reiter, Joshi J. Alumkal, Matthew Rettig, Kim N. Chi, Martin E. Gleave, Owen N. Witte, Theodore C. Goldstein, Stephen J. Freedland, Victor M. Tan, Julie N. Graff
Publikováno v: Prostate cancer and prostatic diseases, vol 22, iss 4
Prostate Cancer and Prostatic Diseases
Nickols, Nicholas G; Nazarian, Ramin; Zhao, Shuang G; Tan, Victor; Uzunangelov, Vladislav; Xia, Zheng; et al.(2019). MEK-ERK signaling is a therapeutic target in metastatic castration resistant prostate cancer.. Prostate cancer and prostatic diseases. doi: 10.1038/s41391-019-0134-5. UCLA: Retrieved from: http://www.escholarship.org/uc/item/1r1692m0
BACKGROUND:Metastatic castration resistant prostate cancer (mCRPC) is incurable and progression after drugs that target the androgen receptor-signaling axis is inevitable. Thus, there is an urgent need to develop more effective treatments beyond horm
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6de3d0f9a6278b7614c715ff8ae22098
https://escholarship.org/uc/item/1r1692m0
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5
Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma
Autor: A. Gordon Robertson, Juliann Shih, Christina Yau, Ewan A. Gibb, Junna Oba, Karen L. Mungall, Julian M. Hess, Vladislav Uzunangelov, Vonn Walter, Ludmila Danilova, Tara M. Lichtenberg, Melanie Kucherlapati, Patrick K. Kimes, Ming Tang, Alexander Penson, Ozgun Babur, Rehan Akbani, Christopher A. Bristow, Katherine A. Hoadley, Lisa Iype, Matthew T. Chang, Andrew D. Cherniack, Christopher Benz, Gordon B. Mills, Roel G.W. Verhaak, Klaus G. Griewank, Ina Felau, Jean C. Zenklusen, Jeffrey E. Gershenwald, Lynn Schoenfield, Alexander J. Lazar, Mohamed H. Abdel-Rahman, Sergio Roman-Roman, Marc-Henri Stern, Colleen M. Cebulla, Michelle D. Williams, Martine J. Jager, Sarah E. Coupland, Bita Esmaeli, Cyriac Kandoth, Scott E. Woodman, Adrian Ally, J. Todd Auman, Miruna Balasundaram, Saianand Balu, Rameen Beroukhim, Inanc Birol, Tom Bodenheimer, Jay Bowen, Reanne Bowlby, Denise Brooks, Rebecca Carlsen, Lynda Chin, Juok Cho, Eric Chuah, Sudha Chudamani, Carrie Cibulskis, Kristian Cibulskis, Leslie Cope, Timothy Defreitas, John A. Demchok, Laurence Desjardins, Noreen Dhalla, Martin L. Ferguson, Scott Frazer, Stacey B. Gabriel, Julie M. Gastier-Foster, Nils Gehlenborg, Mark Gerken, Gad Getz, Elizabeth A. Grimm, D. Neil Hayes, Apurva M. Hegde, David I. Heiman, Carmen Helsel, Shital Hobensack, Robert A. Holt, Alan P. Hoyle, Xin Hu, Carolyn M. Hutter, Stuart R. Jefferys, Corbin D. Jones, Steven J.M. Jones, Katayoon Kasaian, Jaegil Kim, Raju Kucherlapati, Eric Lander, Michael S. Lawrence, Semin Lee, Kristen M. Leraas, Pei Lin, Jia Liu, Wenbin Liu, Laxmi Lolla, Yiling Lu, Yussanne Ma, Harshad S. Mahadeshwar, Odette Mariani, Marco A. Marra, Michael Mayo, Sam Meier, Shaowu Meng, Matthew Meyerson, Piotr A. Mieczkowski, Richard A. Moore, Lisle E. Mose, Andrew J. Mungall, Bradley A. Murray, Rashi Naresh, Michael S. Noble, Angeliki Pantazi, Michael Parfenov, Peter J. Park, Joel S. Parker, Charles M. Perou, Todd Pihl, Robert Pilarski, Alexei Protopopov, Amie Radenbaugh, Karan Rai, Nilsa C. Ramirez, Xiaojia Ren, Sheila M. Reynolds, Jeffrey Roach, Jason Roszik, Sara Sadeghi, Gordon Saksena, Xavier Sastre, Dirk Schadendorf, Jacqueline E. Schein, Steven E. Schumacher, Jonathan Seidman, Sahil Seth, Geetika Sethi, Margi Sheth, Yan Shi, Carol Shields, Ilya Shmulevich, Janae V. Simons, Arun D. Singh, Payal Sipahimalani, Tara Skelly, Heidi Sofia, Matthew G. Soloway, Xingzhi Song, Joshua Stuart, Qiang Sun, Huandong Sun, Angela Tam, Donghui Tan, Jiabin Tang, Roy Tarnuzzer, Barry S. Taylor, Nina Thiessen, Vesteinn Thorsson, Kane Tse, Umadevi Veluvolu, Doug Voet, Yunhu Wan, Zhining Wang, John N. Weinstein, Matthew D. Wilkerson, Lisa Wise, Tina Wong, Ye Wu, Liming Yang, Lixing Yang, Jiashan Zhang, Hailei Zhang, Erik Zmuda
Publikováno v: Cancer cell, vol 32, iss 2
Cancer Cell
Cancer Cell, 32(2), 204
Comprehensive multiplatform analysis of 80 uveal melanomas (UM) identifies four molecularly distinct, clinically relevant subtypes: two associated with poor-prognosis monosomy 3 (M3) and two with better-prognosis disomy 3 (D3). We show that BAP1 loss
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2b2bccbcc49408260b17e33b1915b29
https://hdl.handle.net/1887/115733
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7
A basal stem cell signature identifies aggressive prostate cancer phenotypes
Autor: Donghui Cheng, Kiley Graim, Bryan A. Smith, Yulia Newton, Artem Sokolov, Robert Baertsch, Vladislav Uzunangelov, Colleen Mathis, Owen N. Witte, Joshua M. Stuart
Publikováno v: Smith, BA; Sokolov, A; Uzunangelov, V; Baertsch, R; Newton, Y; Graim, K; et al.(2015). A basal stem cell signature identifies aggressive prostate cancer phenotypes. Proceedings of the National Academy of Sciences of the United States of America, 112(47), E6544-E6552. doi: 10.1073/pnas.1518007112. UCLA: Retrieved from: http://www.escholarship.org/uc/item/5nw7d2hm
Proceedings of the National Academy of Sciences of the United States of America, vol 112, iss 47
Evidence from numerous cancers suggests that increased aggressiveness is accompanied by up-regulation of signaling pathways and acquisition of properties common to stem cells. It is unclear if different subtypes of late-stage cancer vary in stemness
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10e7d52e39a17c707631f264cbeba181
http://www.escholarship.org/uc/item/5nw7d2hm
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8
A community challenge for inferring genetic predictors of gene essentialities through analysis of a functional screen of cancer cell lines
Autor: Mehmet Gönen, Barbara A. Weir, Glenn S. Cowley, Francisca Vazquez, Yuanfang Guan, Alok Jaiswal, Masayuki Karasuyama, Vladislav Uzunangelov, Tao Wang, Aviad Tsherniak, Sara Howell, Daniel Marbach, Bruce Hoff, Thea C. Norman, Antti Airola, Adrian Bivol, Kerstin Bunte, Daniel Carlin, Sahil Chopra, Alden Deran, Kyle Ellrott, Peddinti Gopalacharyulu, Kiley Graim, Samuel Kaski, Suleiman A. Khan, Yulia Newton, Sam Ng, Tapio Pahikkala, Evan Paull, Artem Sokolov, Hao Tang, Jing Tang, Krister Wennerberg, Yang Xie, Xiaowei Zhan, Fan Zhu, Tero Aittokallio, Hiroshi Mamitsuka, Joshua M. Stuart, Jesse S. Boehm, David E. Root, Guanghua Xiao, Gustavo Stolovitzky, William C. Hahn, Adam A. Margolin, Bahman Afsari, Yu-Chuan Chang, Tenghui Chen, Zechen Chong, Haitham Elmarakeby, Elana J. Fertig, Emanuel Gonçalves, Pinghua Gong, Christoph Hafemeister, Lenwood Heath, Łukasz Kędziorski, Niraj Khemka, Erh-kan King, Mario Lauria, Mark Liu, Daniel Machado, Mateusz Mazurkiewicz, Michael P. Menden, Szymon Migacz, Zhi Nie, Paurush Praveen, Corrado Priami, Simone Rizzetto, Miguel Rocha, Cameron Rudd, Witold R. Rudnicki, Julio Saez-Rodriguez, Lei Song, Duanchen Sun, Bence Szalai, Difei Wang, Ling-yun Wu, Jieping Ye, Yuting Ye, Wanding Zhou
Publikováno v: Cell Systems. 5:497-e3
Summary We report the results of a DREAM challenge designed to predict relative genetic essentialities based on a novel dataset testing 98,000 shRNAs against 149 molecularly characterized cancer cell lines. We analyzed the results of over 3,000 submi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2957908881575b5f1b4a60ac2d24987
http://juuli.fi/Record/0282530417
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9
Impact of the National Breast and Cervical Cancer Early Detection Program on cervical cancer mortality among uninsured low-income women in the U.S., 1991-2007
Autor: Vladislav Uzunangelov, Donatus U. Ekwueme, Janet Royalty, Thomas J. Hoerger, Chunyu Li, Evan R. Myers, Mona Saraiya, Vicki B. Benard, Ingrid J. Hall, Jacqueline W. Miller
Publikováno v: American journal of preventive medicine. 47(3)
Background The benefits of the National Breast and Cervical Cancer Early Detection Program (NBCCEDP) on cervical cancer screening for participating uninsured low-income women have never been measured. Purpose To estimate the benefits in life-years (L
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1ab8fc2618eef36df5a93ce02ad6199
https://pubmed.ncbi.nlm.nih.gov/25701947
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10
The Cancer Genome Atlas Pan-Cancer analysis project
Autor: Qunyuan Zhang, B. Arman Aksoy, Fabio Vandin, Eric A. Collisson, Larsson Omberg, S. Onur Sumer, John A. Demchok, Sven Nelander, Vladislav Uzunangelov, Michael C. Wendl, Roger Kramer, John W. Wallis, Brian Craft, Angeliki Pantazi, Leng Han, W. K. Alfred Yung, Brad Ozenberger, Philip L. Lorenzi, James G. Herman, Andy Chu, Sahil Seth, Richard A. Gibbs, Angela Hadjipanayis, Hector Rovira, Peter W. Laird, Inanc Birol, Richard K. Wilson, James Cleland, Peter J. Park, Jiashan Zhang, Payal Sipahimalani, Stanley R. Hamilton, Liming Yang, Seth Lerner, Amie Radenbaugh, Barry S. Taylor, Carrie Hirst, David Tamborero, Stephen B. Baylin, Gad Getz, Tanja Davidsen, Miruna Balasundaram, Cheng Fan, Yuan Yuan, Kristian Cibulskis, Yan Shi, Angela Tam, Divya Kalra, Chris Sander, Scott Abbott, Catrina Fronick, Margi Sheth, Chip Stewart, Angela N. Brooks, Noreen Dhalla, Lam Nguyen, Hui Shen, Travis I. Zack, Andrew J. Mungall, Artem Sokolov, Douglas A. Levine, Carrie Sougnez, Paul T. Spellman, Greg Eley, Deepti Dodda, Wenbin Liu, Michael B. Ryan, Liu Xi, Aaron D. Black, Rong Yao, Saianand Balu, Benjamin P. Berman, Raju Kucherlapati, James M. Melott, Xingzhi Song, Boris Reva, Huyen Dinh, David A. Pot, Michael D. McLellan, Kjong-Van Lehmann, Wenyi Wang, Petar Stojanov, Bradley McIntosh Broom, Timothy J. Ley, Da Yang, Mary Elizabeth Edgerton, Houtan Noushmehr, Mathew G. Soloway, Nina Thiessen, Zhenlin Ju, Mark D.M. Leiserson, Michael Parfenov, Laura van 't Veer, Scott L. Carter, Ludmila Danilova, Adrian Ally, Hailei Zhang, Ina Felau, Carmen Helsel, Kenneth Aldape, Teresia Kling, Charles Lu, Psalm Haseley, A. Gordon Robertson, Andrew Wei Xu, Jessica Frick, Benjamin Gross, Louis M. Staudt, Craig Pohl, Dimitris Anastassiou, Netty Santoso, Donna Muzny, Chad J. Creighton, Donghui Tan, Ryan Bressler, Andrew J. Wong, Barbara Tabak, Yasin Senbabaoglu, Daniel C. Koboldt, Darlene Lee, Doug Voet, Joonil Jung, Hollie A. Harper, Jianhua Zhang, Kyle Chang, Wei Zhao, Marc Ladanyi, Lisa Iype, Ricardo Ramirez, Ami S. Bhatt, Lisle E. Mose, Singer Ma, Abel Gonzalez-Perez, Jonathan G. Seidman, Kosuke Yoshihara, Denise M. Wolf, Corbin D. Jones, Patrik Johansson, Siyuan Zheng, André Kahles, Stacey Gabriel, John N. Weinstein, Han Liang, Samantha Sharpe, Steven E. Schumacher, Matthew Meyerson, D. Neil Hayes, David Haussler, Krishna L. Kanchi, Julie M. Gastier-Foster, Umadevi Veluvolu, Ari B. Kahn, Brady Bernard, Tod D. Casasent, Christopher A. Bristow, Akinyemi I. Ojesina, Sam Ng, Charles M. Perou, Moiz S. Bootwalla, Cyriac Kandoth, Lixing Yang, Joel S. Parker, Alan P. Hoyle, Timothy J. Triche, Dong Zeng, Sean E. McGuire, Christie Kovar, Kim D. Delehaunty, Juok Cho, Alexei Protopopov, Shaowu Meng, Ling Lin, Heather Schmidt, Nils Gehlenborg, Yuexin Liu, Elaine R. Mardis, Martin L. Miller, Jake Lin, Jason Walker, Lisa Wise, Suzanne S. Fei, Jacqueline E. Schein, Semin Lee, Christina Yau, Melisssa Cline, Tara M. Lichtenberg, David I. Heiman, Scot Waring, Richard A. Moore, Margaret B. Morgan, Robert S. Fulton, David E. Larson, Xiaoping Su, Kalle Leinonen, Samirkumar B. Amin, Joshua M. Stuart, J. Todd Auman, Rebecka Jörnsten, Rileen Sinha, Andrew D. Cherniack, Caleb F. Davis, Stephen J. Chanock, Nathan D. Dees, Adam Margolin, Haiyan I. Li, Yaron S.N. Butterfield, Daniel E. Carlin, Tai Hsien Ou Yang, Rameen Beroukhim, Vincent Magrini, Mark P. Hamilton, Grace O. Silva, Nils Weinhold, Harshad S. Mahadeshwar, Michael S. Lawrence, Eric Chuah, Jun Li, Wei Li, Robert A. Burton, Teresa M. Przytycka, Katherine A. Hoadley, Keith A. Baggerly, Sheila M. Reynolds, Daniel DiCara, Tom Bodenheimer, Charles J. Vaske, James M. Eldred, Richard Varhol, Mark A. Jensen, David W. Kane, Xiaojia Ren, Christopher A. Miller, Elizabeth Buda, Li Ding, Michael Mayo, Hsin-Ta Wu, Joelle Kalicki-Veizer, Shelley M. Herbrich, Eunjung Lee, Yingchun Liu, Joshua F. McMichael, Jennifer Drummond, Teresa Swatloski, Harshavardhan Doddapaneni, William Lee, Daniel J. Weisenberger, David A. Wheeler, Chia Chin Wu, Richard Kreisberg, Roeland Verhaak, Elena Helman, Piotr A. Mieczkowski, Mary Goldman, Ilya Shmulevich, Nikolaus Schultz, Min Wang, Lovelace J. Luquette, Marco A. Marra, Todd Pihl, Roy Tarnuzzer, Ronglai Shen, Donna Morton, Yichao Sun, Lawrence A. Donehower, Jun Yao, Theo A. Knijnenburg, Benjamin J. Raphael, Lora Lewis, Peter Waltman, Andrea Eakin, Martin Hirst, Jaegil Kim, Lihua Zou, Ranabir Guin, Yi Han, Scott M. Smith, Hoon Kim, Kristen M. Leraas, Heidi J. Sofia, Erik Zmuda, Matthew D. Wilkerson, Michelle O'Laughlin, Jianjiong Gao, Jeffrey G. Reid, Jing Zhu, Toshinori Hinoue, Gunnar Rätsch, Hye Jung E. Chun, Anders Jacobsen, Stephen C. Benz, Kenna R. Mills Shaw, Gordon B. Mills, Zhining Wang, Cynthia McAllister, Michael S. Noble, Christopher C. Benz, Rehan Akbani, Ruibin Xi, Nianxiang Zhang, Jay Bowen, Wei Zhang, Chandra Sekhar Pedamallu, Eric S. Lander, Yunhu Wan, David J. Dooling, Dong Yeon Cho, Preethi Gunaratne, Todd Wylie, Pei Lin, Chang-Jiun Wu, Jeffrey Roach, Scott Frazer, Samuel S. Freeman, Rachel Abbott, Zheng Xia, Lucinda Fulton, Kyle Ellrott, Nuria Lopez-Bigas, Yang Yang, Michael Miller, Nilsa C. Ramirez, Evan O. Paull, Janae V. Simons, Junyuan Wu, Lynda Chin, Gordon Saksena, Jiabin Tang, Vesteinn Thorsson, Robert A. Holt, Suhn K. Rhie, Steven J.M. Jones, Stuart R. Jeffreys, Giovanni Ciriello, Sofie R. Salama, Gideon Dresdner, Yiling Lu
Publikováno v: Nature
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and epigenetic levels. The resulting rich data provide a major opportunity to develop a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd8c6b63dc15bcd536049f1f948ee442
http://hdl.handle.net/1721.1/84662
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