Zobrazeno 1 - 10
of 231
pro vyhledávání: '"Vladislav A Petyuk"'
Autor:
Shahram Oveisgharan, Lei Yu, Katia de Paiva Lopes, Vladislav A. Petyuk, Shinya Tasaki, Ricardo Vialle, Vilas Menon, Yanling Wang, Philip L. De Jager, Julie A. Schneider, David A. Bennett
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-9 (2024)
Abstract Accumulation of amyloid-β (Aβ) and tau tangles are hallmarks of Alzheimer’s disease. Aβ is extracellular while tau tangles are typically intracellular, and it is unknown how these two proteinopathies are connected. Here, we use data of
Externí odkaz:
https://doaj.org/article/db373cb64bd548c290a7761d99ec2353
Autor:
Rebecca L. Winfree, Emma Nolan, Logan Dumitrescu, Kaj Blennow, Henrik Zetterberg, Katherine A. Gifford, Kimberly R. Pechman, Mabel Seto, Vladislav A. Petyuk, Yanling Wang, Julie Schneider, David A. Bennett, Angela L. Jefferson, Timothy J. Hohman, the Alzheimer’s Disease Neuroimaging Initiative
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-15 (2024)
Abstract Recent evidence suggests that Alzheimer’s disease (AD) genetic risk variants (rs1582763 and rs6591561) of the MS4A locus are genome-wide significant regulators of soluble TREM2 levels such that the minor allele of the protective variant (r
Externí odkaz:
https://doaj.org/article/7f931778e48b4a1db9dee9d86d867c84
Autor:
Praveen-Kumar Raj-Kumar, Xiaoying Lin, Tao Liu, Lori A. Sturtz, Marina A. Gritsenko, Vladislav A. Petyuk, Tyler J. Sagendorf, Brenda Deyarmin, Jianfang Liu, Anupama Praveen-Kumar, Guisong Wang, Jason E. McDermott, Anil K. Shukla, Ronald J. Moore, Matthew E. Monroe, Bobbie-Jo M. Webb-Robertson, Jeffrey A. Hooke, Leigh Fantacone-Campbell, Brad Mostoller, Leonid Kvecher, Jennifer Kane, Jennifer Melley, Stella Somiari, Patrick Soon-Shiong, Richard D. Smith, Richard J. Mural, Karin D. Rodland, Craig D. Shriver, Albert J. Kovatich, Hai Hu
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-24 (2024)
Abstract Background Breast cancer (BC) is the most commonly diagnosed cancer and the leading cause of cancer death among women globally. Despite advances, there is considerable variation in clinical outcomes for patients with non-luminal A tumors, cl
Externí odkaz:
https://doaj.org/article/60e2f6b00711485594ffbd5654bfcc15
Autor:
Steven E. Schutzer, Tao Liu, Chia-Feng Tsai, Vladislav A. Petyuk, Athena A. Schepmoes, Yi-Ting Wang, Karl K. Weitz, Jonas Bergquist, Richard D. Smith, Benjamin H. Natelson
Publikováno v:
Annals of Medicine, Vol 55, Iss 1 (2023)
AbstractBackground Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and fibromyalgia have overlapping neurologic symptoms particularly disabling fatigue. This has given rise to the question whether they are distinct central nervous system
Externí odkaz:
https://doaj.org/article/90cc0b395f50449dbe56f0aabe733dc3
Autor:
Elena Hernández-Hernández, Fernando Yáñez-Gómez, Vladislav. A Petyuk, Philip. L De Jager, Sue Leurgans, Julie Schneider, David. A Bennet, William Honer, María Julia García-Fuster, Alfredo Ramos-Miguel
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S424-S425 (2023)
Externí odkaz:
https://doaj.org/article/66012cd5089446ffb309fba2fc241bb5
Autor:
Guanlan Xu, Tiffany D. Grimes, Truman B. Grayson, Junqin Chen, Lance A. Thielen, Hubert M. Tse, Peng Li, Matt Kanke, Tai-Tu Lin, Athena A. Schepmoes, Adam C. Swensen, Vladislav A. Petyuk, Fernando Ovalle, Praveen Sethupathy, Wei-Jun Qian, Anath Shalev
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Oral verapamil lowers inflammatory markers and daily insulin needs in subjects with type 1 diabetes and helps preserve pancreatic beta cell function for at least two years. In this context, serum chromogranin A provides a promising therapy marker.
Externí odkaz:
https://doaj.org/article/4e4dbf4ca54f400292b98c7c54971be1
Autor:
Shinya Tasaki, Jishu Xu, Denis R. Avey, Lynnaun Johnson, Vladislav A. Petyuk, Robert J. Dawe, David A. Bennett, Yanling Wang, Chris Gaiteri
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Protein changes in a brain with Alzheimer’s are not often accompanied by transcriptional differences. Here, using a deep neural network that predicts protein abundance from mRNA expression, the authors track the early protein changes in Alzheimer
Externí odkaz:
https://doaj.org/article/b2326e42adbe43e48a6a4b74d7fb329d
Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-26 (2022)
Abstract Background Theoretical analysis of signaling pathways can provide a substantial amount of insight into their function. One particular area of research considers signaling pathways capable of assuming two or more stable states given the same
Externí odkaz:
https://doaj.org/article/085b5d84695640dfad1e7c268c280579
Autor:
Aron S. Buchman, Lei Yu, Shahram Oveisgharan, Vladislav A. Petyuk, Shinya Tasaki, Chris Gaiteri, Robert S. Wilson, Francine Grodstein, Julie A. Schneider, Hans-Ulrich Klein, Philip L. De Jager, David A. Bennett
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Motor resilience proteins may be a high value therapeutic target that offset the negative effects of pathologies on motor function. This study sought to identify cortical proteins associated with motor decline unexplained by brain pathologie
Externí odkaz:
https://doaj.org/article/514ab8f92015428598a8892c4c1b5d47
Autor:
Mariko Taga, Vladislav A. Petyuk, Charles White, Galina Marsh, Yiyi Ma, Hans-Ulrich Klein, Sarah M. Connor, Alexandra Kroshilina, Christina J. Yung, Anthony Khairallah, Marta Olah, Julie Schneider, Kyle Karhohs, Anne E. Carpenter, Richard Ransohoff, David A. Bennett, Andrea Crotti, Elizabeth M. Bradshaw, Philip L. De Jager
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-19 (2020)
Abstract Background Identified as an Alzheimer’s disease (AD) susceptibility gene by genome wide-association studies, BIN1 has 10 isoforms that are expressed in the Central Nervous System (CNS). The distribution of these isoforms in different cell
Externí odkaz:
https://doaj.org/article/c07b74e7cd5942fb90b040308c1a35a6