Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Vladislav, Deigin"'
Autor:
Vladislav Deigin, Natalia Linkova, Julia Vinogradova, Dmitrii Vinogradov, Victoria Polyakova, Dmitrii Medvedev, Alexander Krasichkov, Olga Volpina
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 9, p 5042 (2024)
Peptides show high promise in the targeting and intracellular delivery of next-generation biotherapeutics. The main limitation is peptides’ susceptibility to proteolysis in biological systems. Numerous strategies have been developed to overcome thi
Externí odkaz:
https://doaj.org/article/08b7b474566a4cc2a47ac73c8a390c20
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 17, p 13534 (2023)
The oral delivery of peptide pharmaceuticals has long been a fundamental challenge in drug development. A new chemical platform was designed based on branched piperazine-2,5-diones for creating orally available biologically active peptidomimetics. Th
Externí odkaz:
https://doaj.org/article/f38ff5a1d390408495279cb52507570a
Publikováno v:
ChemistrySelect. 8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa9ad7208fb8576243ffa16b82b824b9
https://doi.org/10.1002/slct.202204076
https://doi.org/10.1002/slct.202204076
Publikováno v:
International Journal of Peptide Research and Therapeutics. 28
Vaccines are widely used worldwide to prevent and protect from various infections. A variety of modern approaches to developing prophylactic and therapeutic vaccines is growing. In almost all cases, adjuvants are necessary to obtain an effective immu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbbd1aaa084c293b6d7cb9ffd69e28fe
https://doi.org/10.1007/s10989-022-10461-7
https://doi.org/10.1007/s10989-022-10461-7
Publikováno v:
Tetrahedron. 74:1449-1453
Recently, a novel lignan sevanol was isolated from the thyme plant Thymus armeniacus. During structure-functional elucidation it showed significant biological activity on ASIC3 acid sensing channels. Herein we describe the first synthesis of sevanol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6abcd84c5a307738b3878bc06307a5f6
https://doi.org/10.1016/j.tet.2018.02.005
https://doi.org/10.1016/j.tet.2018.02.005
Autor:
Alexandra Goryacheva, Anastasia A. Ignatova, Oleg N. Yatskin, Vadim T. Ivanov, Vladislav Deigin, Olga Ksenofontova, Alexey V. Feofanov
Publikováno v:
International Immunopharmacology. 81:106185
The novel chemical platform formed by the branched piperazine-2,5-dione peptide derivatives (2,5-diketopiperazines) for creating non-invasive biologically active peptidomimetics has been developed. A successful application of this approach to orally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56216379b090c985b5e507dbb7b646f4
https://doi.org/10.1016/j.intimp.2020.106185
https://doi.org/10.1016/j.intimp.2020.106185
Autor:
Vadim Kublitsky, Rimma Abramovich, Vladimir Shmygarev, Oleg N. Yatskin, Vadim T. Ivanov, Olga Ksenofontova, Maxim Dubinnyi, Vladislav Deigin
Publikováno v:
Journal of peptide science : an official publication of the European Peptide Society. 24(4-5)
A series of linear peptides with the general formula H-Glu(R1)-Glu(R2)-OH was subjected to cyclization under standard conditions. Formation of respective 2,5-diketopiperazines was accompanied by transformation of the N-terminal Glu(R1) to pyroglutami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66f35b4db9c273e7f8c3352d81228fcc
https://pubmed.ncbi.nlm.nih.gov/29575223
https://pubmed.ncbi.nlm.nih.gov/29575223
Autor:
Alexey Khrushchev, Alexandra Goryacheva, Oleg N. Yatskin, Vladislav Deigin, Olga Ksenofontova, Vadim T. Ivanov
Publikováno v:
Chemmedchem
A novel chemical platform based on branched piperazine‐2,5‐dione derivatives (2,5‐diketopiperazines) for creating orally available biologically active peptidomimetics has been developed. The platform includes a diketopiperazine scaffold with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e527983c20dbc7e170ed211cdc5950d
https://pubmed.ncbi.nlm.nih.gov/27457274
https://pubmed.ncbi.nlm.nih.gov/27457274
Publikováno v:
Journal of Chromatography A. 215:263-277
Methods for the analytical and preparative size-exclusion high-performance liquid chromatography of protected hydrophobic peptides in organic solvents were developed. Columns containing Sephadex LH-20 and various silica gels were used and the selecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ba981735f2baadc12477d1946e3dc2b
https://doi.org/10.1016/s0021-9673(00)81405-3
https://doi.org/10.1016/s0021-9673(00)81405-3
Publikováno v:
Prague, Czechoslovakia, August 29–September 3, 1982
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7300e771e80e1aec41c2ff910a8dcecb
https://doi.org/10.1515/9783111694344-054
https://doi.org/10.1515/9783111694344-054
