Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Vladimir Y. Toshchakov"'
A Decoy Peptide that Disrupts TIRAP Recruitment to TLRs Is Protective in a Murine Model of Influenza
Autor:
Wenji Piao, Kari Ann Shirey, Lisa W. Ru, Wendy Lai, Henryk Szmacinski, Greg A. Snyder, Eric J. Sundberg, Joseph R. Lakowicz, Stefanie N. Vogel, Vladimir Y. Toshchakov
Publikováno v:
Cell Reports, Vol 11, Iss 12, Pp 1941-1952 (2015)
Toll-like receptors (TLRs) activate distinct, yet overlapping sets of signaling molecules, leading to inflammatory responses to pathogens. Toll/interleukin-1 receptor (TIR) domains, present in all TLRs and TLR adapters, mediate protein interactions d
Externí odkaz:
https://doaj.org/article/63d2963337ed483eb598fd123302073d
Autor:
Artur Javmen, Jun Zou, Shreeram C. Nallar, Henryk Szmacinski, Joseph R. Lakowicz, Andrew T. Gewirtz, Vladimir Y. Toshchakov
Publikováno v:
The Journal of Immunology. 210:1419-1427
TLR5, which is activated by flagellin, plays an important role in initiating immune response to a broad spectrum of motile bacterial pathogens. TLRs induce intracellular signaling via dimerization of their TIR domains followed by adapter recruitment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::430658fde589e81f1bf052f42ff56b4a
https://doi.org/10.4049/jimmunol.2200394
https://doi.org/10.4049/jimmunol.2200394
Publikováno v:
Immunogenetics
Toll-interleukin-1R resistance (TIR) domains are ubiquitously present in all forms of cellular life. They are most commonly found in signaling proteins, as units responsible for signal-dependent formation of protein complexes that enable amplificatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fba0037e28ede07f0f6c7b8be64b2c8b
https://doi.org/10.1007/s00251-020-01157-7
https://doi.org/10.1007/s00251-020-01157-7
Autor:
Vladimir Y. Toshchakov, Artur Javmen
Publikováno v:
Innate Immunity
Innate Immunity, Vol 26 (2020)
Innate Immunity, Vol 26 (2020)
The ability to engineer pharmaceuticals that target the signal-dependent interactions of signaling proteins should revolutionize drug development. One approach to the rational design of protein interaction inhibitors uses decoy peptides, i.e. segment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0846b50ad42963ea507a1232de38f5e8
http://europepmc.org/articles/PMC6974878
http://europepmc.org/articles/PMC6974878
Publikováno v:
J Leukoc Biol
TLRs sense a broad range of microbial molecules and initiate antimicrobial immune response. The members of the TLR family use cytoplasmic Toll/interleukin-1R homology (TIR) domain to initiate intracellular signaling. The activated TLRs dimerize their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f80edb35e04286b9c0c7ce9ed108298
https://doi.org/10.1002/jlb.2hi0819-180r
https://doi.org/10.1002/jlb.2hi0819-180r
Autor:
Rachel Fanaroff, Alexandra Vlk, Kari Ann Shirey, W.Y.C. Lai, Darren J. Perkins, Chiguang Feng, Shreeram C. Nallar, Stefanie N. Vogel, Vladimir Y. Toshchakov, Andrei E. Medvedev, Kurt H. Piepenbrink, Katharina Richard, Daniel Prantner, Jorge C. G. Blanco, Archana Gopalakrishnan
Publikováno v:
The Journal of Experimental Medicine
We developed mice expressing Tlr4 SNPs homologous to those expressed in humans and associated with infectious and inflammatory diseases. Cellular and molecular analyses of TLR4 signaling in wild-type vs. TLR4-SNP mice revealed novel mechanisms of LPS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d80baa4496263fd37a504de4a831ded
https://doi.org/10.1084/jem.20200675
https://doi.org/10.1084/jem.20200675
Autor:
Vladimir Y Toshchakov, Artur Javmen
Toll-like receptors (TLRs) sense microbial molecules and initiate antimicrobial immune response. The members of the TLR family use cytoplasmic Toll/Interleukin-1R homology (TIR) domain to initiate intracellular signaling. Activated TLRs dimerize thei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d53fbf9ebb8304b616ca120c887097b
Toll-Interleukin-1R Resistance (TIR) domains represent a type of protein fold ubiquitously present in all forms of cellular life. The TIR domains are present in functionally and architecturally diverse proteins. A large subgroup of metazoan TIRs is i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfb51cd2edb41d6e98f954debe62108a
A Decoy Peptide that Disrupts TIRAP Recruitment to TLRs Is Protective in a Murine Model of Influenza
Autor:
Henryk Szmacinski, Kari Ann Shirey, Wenji Piao, Joseph R. Lakowicz, Lisa W. Ru, W.Y.C. Lai, Stefanie N. Vogel, Greg A. Snyder, Vladimir Y. Toshchakov, Eric J. Sundberg
Publikováno v:
Cell Reports, Vol 11, Iss 12, Pp 1941-1952 (2015)
SummaryToll-like receptors (TLRs) activate distinct, yet overlapping sets of signaling molecules, leading to inflammatory responses to pathogens. Toll/interleukin-1 receptor (TIR) domains, present in all TLRs and TLR adapters, mediate protein interac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e3cc97d7106a8ab81c7f3a8b2682e54
Autor:
Eric J. Sundberg, Wenji Piao, Lisa W. Ru, Stefanie N. Vogel, Vladimir Y. Toshchakov, Kurt H. Piepenbrink
Publikováno v:
Proceedings of the National Academy of Sciences. 110:19036-19041
Toll/IL-1R resistance (TIR) domain-containing adapter-inducing IFN-β (TRIF) is a Toll-like receptor (TLR) adapter that mediates MyD88-independent induction of type I interferons through activation of IFN regulatory factor 3 and NFκB. We have examin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96c33733a4cc60cec21021a6f2d235c1
https://doi.org/10.1073/pnas.1313575110
https://doi.org/10.1073/pnas.1313575110