Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Vladimir Veksler"'
Autor:
Mailis Liiv, Annika Vaarmann, Dzhamilja Safiulina, Vinay Choubey, Ruby Gupta, Malle Kuum, Lucia Janickova, Zuzana Hodurova, Michal Cagalinec, Akbar Zeb, Miriam A. Hickey, Yi-Long Huang, Nana Gogichaishvili, Merle Mandel, Mario Plaas, Eero Vasar, Jens Loncke, Tim Vervliet, Ting-Fen Tsai, Geert Bultynck, Vladimir Veksler, Allen Kaasik
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Wolfram syndrome is a rare genetic disease caused by mutations in the WFS1 or CISD2 gene. A primary defect in Wolfram syndrome involves poor ER Ca2+ handling, but how this disturbance leads to the disease is not known. The current study, per
Externí odkaz:
https://doaj.org/article/7119060b6c6844ed9cd995417943a2ed
Autor:
Anne Garnier, Jérôme Leroy, Claudine Deloménie, Philippe Mateo, Benoit Viollet, Vladimir Veksler, Mathias Mericskay, Renée Ventura-Clapier, Jérôme Piquereau
Publikováno v:
PLoS ONE, Vol 18, Iss 9, p e0292015 (2023)
The beta-adrenergic system is a potent stimulus for enhancing cardiac output that may become deleterious when energy metabolism is compromised as in heart failure. We thus examined whether the AMP-activated protein kinase (AMPK) that is activated in
Externí odkaz:
https://doaj.org/article/ac04777b61eb411db0fec894cce101ae
Autor:
Lucile Grimbert, Maria-Nieves Sanz, Mélanie Gressette, Catherine Rucker-Martin, Marta Novotova, Audrey Solgadi, Ahmed Karoui, Susana Gomez, Kaveen Bedouet, Eric Jacquet, Christophe Lemaire, Vladimir Veksler, Mathias Mericskay, Renée Ventura-Clapier, Jérôme Piquereau, Anne Garnier
Publikováno v:
Biology of Sex Differences, Vol 12, Iss 1, Pp 1-24 (2021)
Highlights AMPK is a metabolic sensor of cellular energy which regulates energy homeostasis. We generated a cardiac-specific inducible deletion of Ampkα2 and demonstrated that this deletion induces mild cardiac dysfunction in male only. Cardiac dysf
Externí odkaz:
https://doaj.org/article/81438108d8ef4b59a82a8ad86e49fea4
Autor:
Akbar Zeb, Vinay Choubey, Ruby Gupta, Malle Kuum, Dzhamilja Safiulina, Annika Vaarmann, Nana Gogichaishvili, Mailis Liiv, Ivar Ilves, Kaido Tämm, Vladimir Veksler, Allen Kaasik
Publikováno v:
Redox Biology, Vol 48, Iss , Pp 102186- (2021)
When ROS production exceeds the cellular antioxidant capacity, the cell needs to eliminate the defective mitochondria responsible for excessive ROS production. It has been proposed that the removal of these defective mitochondria involves mitophagy,
Externí odkaz:
https://doaj.org/article/d02ca99c8f53492ab9e9ee6e461b836c
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Adult striated muscle cells present highly organized structure with densely packed intracellular organelles and a very sparse cytosol accounting for only few percent of cell volume. These cells have a high and fluctuating energy demand that, in conti
Externí odkaz:
https://doaj.org/article/f1b1e388be3e413a89f00ac5e0ada775
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2019)
Mitochondria are unique organelles present in almost all cell types. They are involved not only in the supply of energy to the host cell, but also in multiple biochemical and biological processes like calcium homeostasis, production, and regulation o
Externí odkaz:
https://doaj.org/article/47a36e7511cb404aa1a69606f2ee6fd4
Autor:
Maria-Nieves Sanz, Lucile Grimbert, Maryline Moulin, Mélanie Gressette, Catherine Rucker-Martin, Christophe Lemaire, Mathias Mericskay, Vladimir Veksler, Renée Ventura-Clapier, Anne Garnier, Jérôme Piquereau
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 20, p 5005 (2019)
Heart failure is associated with profound alterations of energy metabolism thought to play a major role in the progression of this syndrome. SIRT1 is a metabolic sensor of cellular energy and exerts essential functions on energy metabolism, oxidative
Externí odkaz:
https://doaj.org/article/ebb368a4e1864792ae8eaf055cc74bf6
Autor:
Michal Cagalinec, Mailis Liiv, Zuzana Hodurova, Miriam Ann Hickey, Annika Vaarmann, Merle Mandel, Akbar Zeb, Vinay Choubey, Malle Kuum, Dzhamilja Safiulina, Eero Vasar, Vladimir Veksler, Allen Kaasik
Publikováno v:
PLoS Biology, Vol 14, Iss 7, p e1002511 (2016)
Deficiency of the protein Wolfram syndrome 1 (WFS1) is associated with multiple neurological and psychiatric abnormalities similar to those observed in pathologies showing alterations in mitochondrial dynamics. The aim of this study was to examine th
Externí odkaz:
https://doaj.org/article/cc6c71332b70484f82f9d2c57bdc9e10
Autor:
Stéphanie Rimbaud, Matthieu Ruiz, Jérôme Piquereau, Philippe Mateo, Dominique Fortin, Vladimir Veksler, Anne Garnier, Renée Ventura-Clapier
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26391 (2011)
Heart failure (HF) is characterized by contractile dysfunction associated with altered energy metabolism. This study was aimed at determining whether resveratrol, a polyphenol known to activate energy metabolism, could be beneficial as a metabolic th
Externí odkaz:
https://doaj.org/article/55d71f1aa94a44e58ee99fbbcae90486
Autor:
Malek Kammoun, Lydie Nadal-Desbarats, Sandra Même, Aude Lafoux, Corinne Huchet, Géraldine Meyer-Dilhet, Julien Courchet, Frédéric Montigny, Frédéric Szeremeta, William Même, Vladimir Veksler, Jérôme Piquereau, Philippe Pouletaut, Malayannan Subramaniam, J. Hawse, Jean-Marc Constans, S Bensamoun
Publikováno v:
Journal of Biomedical Science and Engineering. 15:140-156
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::055766e1da6ba4ad00b36af328e4057c
https://doi.org/10.4236/jbise.2022.155014
https://doi.org/10.4236/jbise.2022.155014