Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Vladimir V. Zobov"'
Autor:
Vladimir F. Mironov, Mudaris N. Dimukhametov, Andrey V. Nemtarev, Tatiana N. Pashirova, Olga V. Tsepaeva, Alexandra D. Voloshina, Alexandra B. Vyshtakalyuk, Igor A. Litvinov, Anna P. Lyubina, Anastasiia S. Sapunova, Dinara F. Abramova, Vladimir V. Zobov
Publikováno v:
Nanomaterials, Vol 13, Iss 21, p 2840 (2023)
The creation of mitochondria-targeted vector systems is a new tool for the treatment of socially significant diseases. Phosphonium groups provide targeted delivery of drugs through biological barriers to organelles. For this purpose, a new class of a
Externí odkaz:
https://doaj.org/article/755a68d9d32543f8992b408014263a30
Autor:
Alina M. Ermakova, Julia E. Morozova, Yana V. Shalaeva, Victor V. Syakaev, Aidar T. Gubaidullin, Alexandra D. Voloshina, Vladimir V. Zobov, Irek R. Nizameev, Olga B. Bazanova, Igor S. Antipin, Alexander I. Konovalov
Publikováno v:
Beilstein Journal of Nanotechnology, Vol 9, Iss 1, Pp 2057-2070 (2018)
In order to obtain a non-toxic amphiphilic calixresorcinarene capable to form nanoconjugates for drug encapsulation, tetraundecylcalixresorcinarene functionalized by methoxy poly(ethylene glycol) chains has been synthesized. The macrocycle obtained i
Externí odkaz:
https://doaj.org/article/56a2363bfd9e40d79a7298c5b9f938f4
Autor:
Vladimir V. Zobov, V. E. Semenov, G. P. Belyaev, I. V. Galyametdinova, A. A. Parfenov, M. S. Shashyn, A. B. Vyshtakalyuk
Publikováno v:
Russian Journal of Bioorganic Chemistry. 46:1067-1073
“Double” derivatives of the drug Xymedon (1,2-dihydro-4,6-dimethyl-1-N-(hydroxyethyl)pyrimidone-2), hereafter referred to as pyrimidine (I), in which the pyrimidine (I) molecules are joined by an alkyl(xylylenyl)dionate bridge have been synthesiz
Autor:
I. V. Galyametdinova, A. A. Parfenov, Vladimir V. Zobov, V. E. Semenov, Nail Nazarov, L. R. Khasanshina, D. A. Kondrashina, A. B. Vyshtakalyuk, L. F. Gumarova, G. P. Belyaev
Publikováno v:
Russian Chemical Bulletin. 68:2307-2315
A salt-like conjugate of xymedone with para-aminobenzoic acid in a series of pyrimidine derivatives was synthesized, and its hepatoprotective properties were studied. The compound studied exhibits a cytoprotective effect at a concentration of 25 μmo
Autor:
A. D. Latipova, Vladimir V. Zobov, L. F. Gumarova, A. B. Vyshtakalyuk, A. A. Parfenov, M. A. Sysoeva, E. V. Sysoeva
Publikováno v:
BioNanoScience. 9:528-538
The purpose of this study is to identify hepatoprotective properties of melanins from aqueous extracts of Inonotus obliquus distinguished by microwave modes used in extraction in both in vitro and in vivo studies. In vitro tests were used in studies
Publikováno v:
MODERN SYNTHETIC METHODOLOGIES FOR CREATING DRUGS AND FUNCTIONAL MATERIALS (MOSM2020): PROCEEDINGS OF THE IV INTERNATIONAL CONFERENCE.
A laboratory culture of Chlorella was used to evaluate the toxicity of L-ascorbate 1-(2-hydroxyethyl)- 4,6-dimethyl-1,2-dihydropyrimidine-2-one synthesized on the basis of the drug Xymedon. Acute toxic effect by inhibiting the growth of Chlorella vul
Publikováno v:
MODERN SYNTHETIC METHODOLOGIES FOR CREATING DRUGS AND FUNCTIONAL MATERIALS (MOSM2020): PROCEEDINGS OF THE IV INTERNATIONAL CONFERENCE.
The effect of the L-ascorbate 1-(2-hydroxyethyl)-4,6-dimethyl-1,2-dihydropyrimidine-2-one on blastema regeneration in Girardia tigrina planarians was investigated. It was established that the preparation has low toxicity towards planarians, which is
Publikováno v:
MODERN SYNTHETIC METHODOLOGIES FOR CREATING DRUGS AND FUNCTIONAL MATERIALS (MOSM2020): PROCEEDINGS OF THE IV INTERNATIONAL CONFERENCE.
Autor:
Darya A Kondrashina, I. V. Galyametdinova, Grigory P Belyaev, A. B. Vyshtakalyuk, Vyacheslav E. Semenov, Vladimir V. Zobov, A. A. Parfenov, Leyla R Khasanshina, L. F. Gumarova, Nail Nazarov
Publikováno v:
Journal of biochemical and molecular toxicologyREFERENCES. 35(3)
The aim of the study was to investigate the hepatoprotective properties of the conjugate of the xymedon drug substance with succinic acid (1a). The study presents an in vitro comparative evaluation of the cytotoxicity and cytoprotective properties of
Autor:
Julia E. Morozova, Yana V. Shalaeva, Vladimir F. Mironov, Andrei V. Bogdanov, Alexandra D. Voloshina, Irek R. Nizameev, Vladimir V. Zobov, Alexander I. Konovalov, Victor V. Syakaev, A. M. Ermakova, Marsil K. Kadirov
Publikováno v:
Colloids and Surfaces A: Physicochemical and Engineering Aspects. 553:368-377
Here we present the consecutive study of colloid systems formed by novel isatin derivative as compound with high pharmacological potential and series of carboxyresorcinarenes. The azo-modified isatin derivative bearing ammonium moiety (I-3) was synt