Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Vladimir V. Rymar"'
Autor:
Etienne Gauthier-Lafreniere, Meshal Aljassar, Vladimir V. Rymar, John Milton, Abbas F. Sadikot
Publikováno v:
Frontiers in Neuroinformatics, Vol 16 (2022)
BackgroundOrdinal scales based on qualitative observation are the mainstay in the clinical assessment of tremor, but are limited by inter-rater reliability, measurement precision, range, and ceiling effects. Quantitative tremor evaluation is well-dev
Externí odkaz:
https://doaj.org/article/9008ae253994429da16b31f1e12c986d
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-19 (2020)
Abstract Huntington’s disease (HD) is an autosomal dominant trinucleotide repeat disorder characterized by choreiform movements, dystonia and striatal neuronal loss. Amongst multiple cellular processes, abnormal neurotransmitter signalling and decr
Externí odkaz:
https://doaj.org/article/179f6ff7cfc84881a12e199ce94b16b0
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 10 (2016)
The principal projection neurons of the striatum are critically dependent on an afferent supply of brain derived neurotrophic factor (BDNF) for neurotrophic support. These neurons express TrkB, the cognate receptor for BDNF, which activates signaling
Externí odkaz:
https://doaj.org/article/cc0f627b75df45a9a0c0be0eb7663a6b
Autor:
Erin K. O'Ferrall, Vladimir V. Rymar, Abbas F. Sadikot, Bernard Brais, Marie Josée Dicaire, Rebecca Robertson, Robert J. Bryson-Richardson, Talita C. Conte, Jason C. Young, Josée N. Lavoie
Publikováno v:
The American Journal of Pathology. 190:554-562
BCL-2-associated athanogene 3 (BAG3) is a co-chaperone to heat shock proteins important in degrading misfolded proteins through chaperone-assisted selective autophagy. The recurrent dominant BAG3-P209L mutation results in a severe childhood-onset myo
Publikováno v:
Journal of neurochemistry. 161(3)
Mechanisms that determine the survival of midbrain dopaminergic (mDA) neurons in the adult central nervous system (CNS) are not fully understood. Netrins are a family of secreted proteins that are essential for normal neural development. In the matur
Autor:
Abbas F. Sadikot, M. Mallar eChakravarty, Gilles eBertrand, Vladimir V Rymar, Fahd eAl-Subaie, D. Louis eCollins
Publikováno v:
Frontiers in Systems Neuroscience, Vol 5 (2011)
Functional brain imaging and neurosurgery in subcortical areas often requires visualization of brain nuclei beyond the resolution of current Magnetic Resonance Imaging (MRI) methods. We present techniques used to create: 1) a lower resolution 3D atla
Externí odkaz:
https://doaj.org/article/4d097d8d608345209c964021be408f07
Autor:
Rebecca, Robertson, Talita C, Conte, Marie-Josée, Dicaire, Vladimir V, Rymar, Abbas F, Sadikot, Robert J, Bryson-Richardson, Josée N, Lavoie, Erin, O'Ferrall, Jason C, Young, Bernard, Brais
Publikováno v:
The American journal of pathology. 190(3)
BCL-2-associated athanogene 3 (BAG3) is a co-chaperone to heat shock proteins important in degrading misfolded proteins through chaperone-assisted selective autophagy. The recurrent dominant BAG3-P209L mutation results in a severe childhood-onset myo
Autor:
Edwin W. Wong, Lianne J. Trigiani, Timothy E. Kennedy, Abbas F. Sadikot, Daryan Chitsaz, Vladimir V. Rymar, Edith Hamel, Edward S. Ruthazer, Stephen D. Glasgow
Netrin-1 was initially characterized as an axon guidance molecule that is essential for normal embryonic neural development; however, many types of neurons continue to express netrin-1 in the post-natal and adult mammalian brain. Netrin-1 and the net
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb87f2169cdd94201b1dbc53b89019c0
https://europepmc.org/articles/PMC6380201/
https://europepmc.org/articles/PMC6380201/
Autor:
Stefan Nicolau, Claude Steriade, Pepijn van den Munckhof, Jacques Drouin, Panojot Bifsha, Kelvin C. Luk, Vladimir V. Rymar, Abbas F. Sadikot
Publikováno v:
Journal of Neurochemistry. 125:932-943
The homeodomain transcription factor Pitx3 is critical for the survival of midbrain dopaminergic (mDA) neurons. Pitx3-deficient mice exhibit severe but selective developmental loss of mDA neurons, with accompanying locomotor deficits resembling those
Autor:
Jérôme Maheux, Jean-François Cloutier, F. Beaubien, Alexandre Boutet, Vladimir V. Rymar, P. Samadi, J.-C. Kvann, Abbas F. Sadikot, K. Rawal, Daniel Lévesque, M. Tomaszewski
Publikováno v:
Genes, Brain and Behavior. 12:108-124
Patients with Huntington's disease (HD) and transgenic mouse models of HD show neuronal loss in the striatum as a major feature, which contributes to cognitive and motor manifestations. Reduced expression of the neurotrophin brain-derived neurotrophi