Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Vladimir V. Lupashin"'
Autor:
Clem Marsilia, Mrinalini Batra, Irina D. Pokrovskaya, Changqi Wang, Dale Chaput, Daria A. Naumova, Vladimir V. Lupashin, Elena S. Suvorova
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTSurvival of the apicomplexan parasite Toxoplasma gondii depends on the proper functioning of many glycosylated proteins. Glycosylation is performed in the major membranous organelles ER and Golgi apparatus that constitute a significant portio
Externí odkaz:
https://doaj.org/article/8b17efa4fcee4d43b024e78374b08cb9
Autor:
Milena Dimori, Irina D. Pokrovskaya, Shijie Liu, John T. Sherrill, Horacio Gomez-Acevedo, Qiang Fu, Brian Storrie, Vladimir V. Lupashin, Roy Morello
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Smith McCort (SMC) dysplasia is a rare, autosomal recessive, osteochondrodysplasia that can be caused by pathogenic variants in either RAB33B or DYM genes. These genes codes for proteins that are located at the Golgi apparatus and have a role in intr
Externí odkaz:
https://doaj.org/article/d94a2c4c6eae415fa7aff58c2e50c49b
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Golgi-associated retrograde protein (GARP) is an evolutionary conserved heterotetrameric protein complex that tethers endosome-derived vesicles and is vital for Golgi glycosylation. Microscopy and proteomic approaches were employed to investigate def
Externí odkaz:
https://doaj.org/article/e1bfa85481204be89812639e34330c6b
Autor:
Zinia D’Souza, Jessica Bailey Blackburn, Tetyana Kudlyk, Irina D. Pokrovskaya, Vladimir V. Lupashin
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
The conserved oligomeric complex (COG) is a multi-subunit vesicle tethering complex that functions in retrograde trafficking at the Golgi. We have previously demonstrated that the formation of enlarged endo-lysosomal structures (EELSs) is one of the
Externí odkaz:
https://doaj.org/article/a586133a4ccd4d75b4aec0fdacb3a45d
Publikováno v:
Traffic. 24:52-75
Conserved Oligomeric Golgi (COG) complex controls Golgi trafficking and glycosylation, but the precise COG mechanism is unknown. The auxin-inducible acute degradation system was employed to investigate initial defects resulting from COG dysfunction.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bba1ba663cc579e7051c432c9f1a455
https://doi.org/10.1111/tra.12876
https://doi.org/10.1111/tra.12876
Publikováno v:
Methods Mol Biol
Methods in Molecular Biology ISBN: 9781071626382
Methods in Molecular Biology ISBN: 9781071626382
Conserved oligomeric Golgi (COG) complex orchestrates intra-Golgi retrograde trafficking and glycosylation of macromolecules, but the detailed mechanism of COG action is unknown. Previous studies employed prolonged protein knockout and knockdown appr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9f86957737cee6b067782e669df749c
https://europepmc.org/articles/PMC10019459/
https://europepmc.org/articles/PMC10019459/
Publikováno v:
Methods in Molecular Biology ISBN: 9781071626382
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5b59e01784a745146659bb9563ca399
https://doi.org/10.1007/978-1-0716-2639-9_48
https://doi.org/10.1007/978-1-0716-2639-9_48
GARP is an evolutionary conserved heterotetrameric protein complex that is thought to tether endosome-derived vesicles and promotes their fusion in the trans-Golgi network. We have previously discovered the GARP’s role in maintaining Golgi glycosyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa8d65781f49b517bb90ddebb5cadf1d
https://doi.org/10.1101/2022.07.22.501184
https://doi.org/10.1101/2022.07.22.501184
Autor:
Amrita Khakurel, Vladimir V. Lupashin
Publikováno v:
International Journal of Molecular Sciences. 24:6069
The Golgi associated retrograde protein complex (GARP) is an evolutionarily conserved component of Golgi membrane trafficking machinery that belongs to the Complexes Associated with Tethering Containing Helical Rods (CATCHR) family. Like other multis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50b2f64ba81f7c7cc53657e33e58f8e4
https://doi.org/10.3390/ijms24076069
https://doi.org/10.3390/ijms24076069
The intracellular transport system is an evolutionally conserved, essential, and highly regulated network of organelles and transport vesicles that traffic protein and lipid cargoes within the cell. The events of vesicle formation, budding and fusion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f61f0d19e9423a90ad1c19f615737cf
https://doi.org/10.1101/2022.05.24.493304
https://doi.org/10.1101/2022.05.24.493304