Elucidating Binding Sites and Affinities of ERα Agonists and Antagonists to Human Alpha-Fetoprotein by In Silico Modeling and Point Mutagenesis

Autor: Vladimir V. Kadochnikov, Nikolai N. Kuzmich, Yuri B. Porozov, Alexander A Terentiev, N. T. Moldogazieva, Daria S Ostroverkhova

Publikováno v: International Journal of Molecular Sciences
Volume 21
Issue 3
International Journal of Molecular Sciences, Vol 21, Iss 3, p 893 (2020)

Alpha-fetoprotein (AFP) is a major embryo- and tumor-associated protein capable of binding and transporting a variety of hydrophobic ligands, including estrogens. AFP has been shown to inhibit estrogen receptor (ER)-positive tumor growth, which can b

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Elucidating Binding Sites and Affinities of ERα Agonists and Antagonists to Human Alpha-Fetoprotein by In Silico Modeling and Point Mutagenesis.

Autor: Moldogazieva, Nurbubu T.¹ (AUTHOR) daria.ostroverkhova@gmail.com, Ostroverkhova, Daria S.^1,2 (AUTHOR) nkuzmich@gmail.com, Kuzmich, Nikolai N.^1,3 (AUTHOR) yuri.porozov@gmail.com, Kadochnikov, Vladimir V.⁴ (AUTHOR) vlkadochnikov@gmail.com, Terentiev, Alexander A.⁵ (AUTHOR) aaterent@inbox.ru, Porozov, Yuri B.^1,4 (AUTHOR)

Publikováno v: International Journal of Molecular Sciences. 2/1/2020, Vol. 21 Issue 3, p893. 1p. 5 Diagrams, 3 Charts, 3 Graphs.