BTK and PLCG2 remain unmutated in one-third of patients with CLL relapsing on ibrutinib.

Autor: Bonfiglio S; Centre for Omics Sciences, IRCCS Ospedale San Raffaele, Milan, Italy.; Division of Experimental Oncology, B cell Neoplasia Unit, IRCCS Ospedale San Raffaele, Milan, Italy., Sutton LA; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Ljungström V; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Sweden., Capasso A; Strategic Research Program on CLL, IRCCS Ospedale San Raffaele, Milan, Italy., Pandzic T; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Sweden., Weström S; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Sweden., Foroughi-Asl H; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Skaftason A; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Gellerbring A; Clinical Genomics Stockholm, Science for Life Laboratory, Solna, Sweden.; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden., Lyander A; Clinical Genomics Stockholm, Science for Life Laboratory, Solna, Sweden.; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.; School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Stockholm, Sweden., Gandini F; Division of Experimental Oncology, B cell Neoplasia Unit, IRCCS Ospedale San Raffaele, Milan, Italy.; Università Vita-Salute San Raffaele, Milan, Italy., Gaidano G; Division of Hematology, Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy., Trentin L; Department of Medicine, Hematology and Clinical Immunology, University of Padua, Italy., Bonello L; Molecular Pathology Unit, A.O.U Città della Salute e della Scienza, Torino, Italy.; Department of Molecular Biotechnologies and Health Sciences, Università di Torino, Italy., Reda G; Department of Hematology, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Bödör C; HCEMM-SU Molecular Oncohematology Research Group, Budapest, Hungary.; 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary., Stavroyianni N; Department of Hematology and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece., Tam CS; Department of Hematology, Alfred Health, Melbourne, Victoria, Australia.; Central Clinical School, Monash University, Melbourne, Victoria, Australia., Marasca R; Department of Medical and Surgical Sciences, Hematology Unit, University of Modena and Reggio Emilia, Modena, Italy., Forconi F; School of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.; Department of Hematology, University Hospital National Health Service Trust, Southampton, United Kingdom., Panayiotidis P; Department of Propaedeutic Internal Medicine, Laiko Hospital, University of Athens, Athens, Greece., Ringshausen I; Department of Hematology, University of Cambridge, Cambridge, United Kingdom., Jaksic O; Dubrava University Hospital, Zagreb, Croatia., Frustaci AM; Department of Hematology, Niguarda Cancer Center, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy., Iyengar S; Department of Haemato-Oncology, Royal Marsden Hospital, London, United Kingdom., Coscia M; Department of Molecular Biotechnologies and Health Sciences, Università di Torino, Italy.; Division of Hematology, A.O.U. Città della Salute e della Scienza di Torino, Torino, Italy., Mulligan SP; Department of Haematology, Royal North Shore Hospital, University of Sydney, Sydney, Australia., Ysebaert L; Département d'Hématologie, Institut Universitaire du Cancer-Oncopole de Toulouse, Toulouse, France., Strugov V; Almazov National Medical Research Centre, St Petersburg, Russia., Pavlovsky C; FUNDALEU, Clinical Research Center, Buenos Aires, Argentina., Walewska R; Department of Molecular Pathology, University Hospitals Dorset, Bournemouth, United Kingdom., Österborg A; Department of Hematology, Karolinska University Hospital, Stockholm, Sweden., Cortese D; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Ranghetti P; Division of Experimental Oncology, B cell Neoplasia Unit, IRCCS Ospedale San Raffaele, Milan, Italy., Baliakas P; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Sweden., Stamatopoulos K; Institute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki, Greece., Scarfò L; Division of Experimental Oncology, B cell Neoplasia Unit, IRCCS Ospedale San Raffaele, Milan, Italy.; Strategic Research Program on CLL, IRCCS Ospedale San Raffaele, Milan, Italy.; Università Vita-Salute San Raffaele, Milan, Italy., Rosenquist R; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.; Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden., Ghia P; Division of Experimental Oncology, B cell Neoplasia Unit, IRCCS Ospedale San Raffaele, Milan, Italy.; Strategic Research Program on CLL, IRCCS Ospedale San Raffaele, Milan, Italy.; Università Vita-Salute San Raffaele, Milan, Italy.

Publikováno v: Blood advances [Blood Adv] 2023 Jun 27; Vol. 7 (12), pp. 2794-2806.

COVID-19 severity and mortality in patients with chronic lymphocytic leukemia: a joint study by ERIC, the European Research Initiative on CLL, and CLL Campus.

Autor: Scarfò L; Università Vita-Salute San Raffaele and IRCC Ospedale San Raffaele, Milan, Italy., Chatzikonstantinou T; Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece., Rigolin GM; Hematology Section, Department of Medical Sciences, University of Ferrara, Ferrara, Italy., Quaresmini G; USC Ematologia, ASST PAPA GIOVANNI XXIII, Bergamo, Italy., Motta M; S.C. Ematologia, ASST Spedali Civili, Brescia, Italy., Vitale C; University Division of Hematology, A.O.U. Città della Salute e della Scienza di Torino and Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy., Garcia-Marco JA; Hematology Department, Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain., Hernández-Rivas JÁ; Hospital Universitario Infanta Leonor, Madrid Universidad Complutense, Madrid, Spain., Mirás F; Hospital Universitario 12 de Octubre, Madrid, Spain., Baile M; Servicio de Hematología del Complejo Asistencial Universitario de Salamanca-IBSAL, Salamanca, Spain., Marquet J; Hematology Department, Hospital Universitario Ramón y Cajal, Madrid, Spain., Niemann CU; Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Reda G; U.O.C. Ematologia, Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico, Milan, Italy., Munir T; St James's University Hospital, Leeds, UK., Gimeno E; Hematology Department Hospital del Mar, Barcelona, Spain., Marchetti M; Hematology Dpt, Az Osp SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy., Quaglia FM; Department of Medicine, Section of Hematology, University of Verona, Verona, Italy., Varettoni M; Division of Haematology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Delgado J; Dept. of Hematology, Hospital Clinic, IDIBAPS, Barcelona, Spain., Iyengar S; Department of Haemato-Oncology, Royal Marsden Hospital, London, UK., Janssens A; Universitaire Ziekenhuizen Leuven, Leuven, Belgium., Marasca R; Hematology Unit, Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy., Ferrari A; Hematology, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy., Cuéllar-García C; Hematology Unit, Consorci Sanitari Terrassa Hospital, Terrassa, Spain., Itchaki G; Rabin Medical Center, Beilinson Hospital; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Špaček M; 1st Department of Medicine-Department of Hematology, First Faculty of Medicine, Charles University and General Hospital in Prague, Prague, Czech Republic., De Paoli L; Division of Hematology, Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy., Laurenti L; Dipartimento Scienze Radiologiche ed Ematologiche, Divisione di Ematologia Fondazione Policlinico universitario A Gemelli, Roma, Italy., Levin MD; Department of Internal Medicine, Albert Schweitzer Hospital, Dordrecht, The Netherlands., Lista E; Struttura Semplice Dipartimentale di Ematologia, Presidio Ospedaliero Santa Chiara, Trento, Italy., Mauro FR; Hematology, Department of Translational and Precision Medicine, Sapienza University, Policlinico Umberto I, Rome, Italy., Šimkovič M; Department of Internal Medicine-Haematology, University Hospital and Medical School Hradec Kralove, Hradec Kralove, Czech Republic., Van Der Spek E; Internal Medicine, Rijnstate Hospital, Arnhem, The Netherlands., Vandenberghe E; Department of Haematology, St James Hospital and Trinity College Dublin, Dublin, Ireland., Trentin L; Hematology Unit, University of Padua, Padua, Italy., Wasik-Szczepanek E; Dept. Hematooncology and Bone Marrow Transplantation, Medical University in Lublin, Lublin, Poland., Ruchlemer R; Department of Hematology, Shaare Zedek Medical Center, Jerusalem, Israel., Bron D; Inst J Bordet (ULB), Brussels, Belgium., De Paolis MR; UOC Ematologia PO Vito Fazzi Lecce, Lecce, Italy., Del Poeta G; Cattedra di Ematologia Dipartimento di Biomedicina e Prevenzione, Università Tor Vergata Roma, Rome, Italy., Farina L; Division of Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy., Foglietta M; SC Ematologia, AO S. Croce e Carle, Cuneo, Italy., Gentile M; UOC Ematologia AO Cosenza, Cosenza, Italy., Herishanu Y; Department of Hematology, Tel Aviv Sourasky Medical Center, and Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel., Herold T; Department of Medicine III, University Hospital, LMU Munich, Munich, Germany., Jaksic O; Department of Hematology, University hospital Dubrava, Zagreb, Croatia., Kater AP; Dep of Hematology, Cancer Center Amsterdam, Amsterdam University Medical Centers, Amsterdam, The Netherlands., Kersting S; Department of Hematology, Haga Hospital, The Hague, The Netherlands., Malerba L; Hematology Unit, Azienda Ospedaliera 'Ospedali Riuniti Marche Nord', Pesaro, Italy., Orsucci L; Division of Hematology II, San Giovanni Battista Hospital, Torino, Italy., Popov VM; Colentina Clinical Hospital Bucharest, Bucharest, Romania., Sportoletti P; Institute of Hematology and Center for Hemato-Oncological Research, Ospedale S. Maria della Misericordia, University of Perugia, Perugia, Italy., Yassin M; National Center for Cancer Care and Research Doha, Doha, Qatar., Pocali B; Division of Hematology and Stem Cell Transplantation Unit, Cardarelli Hospital, Naples, Italy., Barna G; 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary., Chiarenza A; Division of Hematology, Policlinico, Department of Surgery and Medical Specialties, University of Catania, Catania, Italy., Dos Santos G; Hospital de Clinicas, Montevideo, Uruguay., Nikitin E; Department of Hematology, Oncology, and Chemotherapy, S. P. Botkin's City Hospital, Moscow, Russia., Andres M; Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Dimou M; 1st First Propedeutic Department of Internal Medicine, Hematology Unit, Laikon General Hospital, National and Kapodistrian University of Athens, Medical School of Athens, Athens, Greece., Doubek M; University Hospital and CEITEC MU Brno, Brno, Czech Republic., Enrico A; Hematology Area, Hospital Italiano La Plata, La Plata, Argentina., Hakobyan Y; Hematology Center after Prof. Yeolyan MH RA, Yerevan, Armenia., Kalashnikova O; First State Pavlov Medical University of Saint-Petersburg, Raisa Gorbacheva Memorial Institute for Children Oncology, Hematology and Transplantation Russia, Saint-Petersburg, Russia., Ortiz Pareja M; Carlos Haya, Málaga, Spain., Papaioannou M; Hematology Unit, 1st Dept of Internal Medicine, AUTH, AHEPA Hospital, Thessaloniki, Greece., Rossi D; Laboratory of Experimental Hematology, Institute of Oncology Research, Bellinzona, Switzerland.; Division of Hematology, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland., Shah N; Norfolk & Norwich University NHS Foundation Trust, Norwich, UK., Shrestha A; Hematology Unit, Nepal Cancer Hospital & Research Centre, Lalitpur, Nepal., Stanca O; 'Carol Davila' University of Medicine and Pharmacy, Hematology Clinic, Coltea Clinical Hospital, Bucharest, Romania., Stavroyianni N; Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece., Strugov V; Hematology Almazov National Medical Research Centre, St. Petersburg, Russia., Tam C; Peter MacCallum Cancer Centre and University of Melbourne, Victoria, Australia., Zdrenghea M; Department of Hematology, Iuliu Hatieganu University of Medicine and Pharmacy and Ion Chiricuta Oncology Institute, Cluj-Napoca, Romania., Coscia M; University Division of Hematology, A.O.U. Città della Salute e della Scienza di Torino and Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy., Stamatopoulos K; Institute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki, Greece. kostas.stamatopoulos@certh.gr., Rossi G; S.C. Ematologia, ASST Spedali Civili, Brescia, Italy., Rambaldi A; USC Ematologia, ASST PAPA GIOVANNI XXIII, Bergamo, Italy., Montserrat E; Dept. of Hematology, Hospital Clinic, IDIBAPS, Barcelona, Spain., Foà R; Hematology, Department of Translational and Precision Medicine, Sapienza University, Policlinico Umberto I, Rome, Italy., Cuneo A; Hematology Section, Department of Medical Sciences, University of Ferrara, Ferrara, Italy., Ghia P; Università Vita-Salute San Raffaele and IRCC Ospedale San Raffaele, Milan, Italy. ghia.paolo@hsr.it.

Publikováno v: Leukemia [Leukemia] 2020 Sep; Vol. 34 (9), pp. 2354-2363. Date of Electronic Publication: 2020 Jul 09.

Ibrutinib plus obinutuzumab versus chlorambucil plus obinutuzumab in first-line treatment of chronic lymphocytic leukaemia (iLLUMINATE): a multicentre, randomised, open-label, phase 3 trial.

Autor: Moreno C; Department of Hematology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain. Electronic address: cmorenoa@santpau.cat., Greil R; Paracelsus Medical University Salzburg, Salzburg Cancer Research Institute, Cancer Cluster Salzburg, Salzburg, Austria., Demirkan F; Dokuz Eylul University, Izmir, Turkey., Tedeschi A; ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy., Anz B; Tennessee Oncology, Chattanooga, TN, USA., Larratt L; University of Alberta, Edmonton, AB, Canada., Simkovic M; University Hospital Hradec Kralove, Charles University, Hradec Kralove, Czech Republic., Samoilova O; Nizhny Novogorod Regional Clinical Hospital, Nizhny Novogorod, Russia., Novak J; University Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles University, Prague, Czech Republic., Ben-Yehuda D; Department of Hematology, Hadassah Medical Center, Hebrew University of Jerusalem, The Faculty of Medicine, Jerusalem, Israel., Strugov V; Almazov National Medical Research Centre, St Petersburg, Russia., Gill D; Princess Alexandra Hospital, Brisbane, QLD, Australia., Gribben JG; Barts Cancer Institute, Queen Mary University of London, London, UK., Hsu E; Pharmacyclics LLC, an AbbVie Company, Sunnyvale, CA, USA., Lih CJ; Pharmacyclics LLC, an AbbVie Company, Sunnyvale, CA, USA., Zhou C; Pharmacyclics LLC, an AbbVie Company, Sunnyvale, CA, USA., Clow F; Pharmacyclics LLC, an AbbVie Company, Sunnyvale, CA, USA., James DF; Pharmacyclics LLC, an AbbVie Company, Sunnyvale, CA, USA., Styles L; Pharmacyclics LLC, an AbbVie Company, Sunnyvale, CA, USA., Flinn IW; Sarah Cannon Research Institute/Tennessee Oncology, Nashville, TN, USA.

Publikováno v: The Lancet. Oncology [Lancet Oncol] 2019 Jan; Vol. 20 (1), pp. 43-56. Date of Electronic Publication: 2018 Dec 03.