Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Vladimir V, Koval"'
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 5, Pp 4119-4132 (2024)
8-oxoguanine (oxoG) is formed in DNA by the action of reactive oxygen species. As a highly mutagenic and the most common oxidative DNA lesion, it is an important marker of oxidative stress. Human 8-oxoguanine-DNA glycosylase (OGG1) is responsible for
Externí odkaz:
https://doaj.org/article/63d33fd6e14f4273bded503fcbdf8732
Autor:
Svetlana V. Baranova, Polina V. Zhdanova, Anastasia D. Koveshnikova, Pavel E. Pestryakov, Ivan P. Vokhtantsev, Alexander A. Chernonosov, Vladimir V. Koval
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 19, p 10862 (2024)
The non-ideal accuracy and insufficient selectivity of CRISPR/Cas9 systems is a serious problem for their use as a genome editing tool. It is important to select the target sequence correctly so that the CRISPR/Cas9 system does not cut similar sequen
Externí odkaz:
https://doaj.org/article/ef2c4557c74b425cac2a86543e39cd27
Autor:
Alexander A. Chernonosov, Irina A. Mednova, Lyudmila A. Levchuk, Ekaterina O. Mazurenko, Olga V. Roschina, German G. Simutkin, Nikolay A. Bokhan, Vladimir V. Koval, Svetlana A. Ivanova
Publikováno v:
Metabolites, Vol 14, Iss 2, p 110 (2024)
Depressive disorder is a multifactorial disease that is based on dysfunctions in mental and biological processes. The search for biomarkers can improve its diagnosis, personalize therapy, and lead to a deep understanding of the biochemical processes
Externí odkaz:
https://doaj.org/article/8504bd29c8dc47b8b738c34829a971d0
Autor:
Vera A. Kostikova, Natalia V. Petrova, Alexander A. Chernonosov, Vladimir V. Koval, Evgeniia R. Kovaleva, Wei Wang, Andrey S. Erst
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 989 (2024)
Anemonopsis Siebold et Zucc. is an unstudied single-species genus belonging to the tribe Cimicifugeae (Ranunculaceae). The only species of this genus—Anemonopsis macrophylla Siebold and Zucc.—is endemic to Japan. There are no data on its chemical
Externí odkaz:
https://doaj.org/article/d63cbc744f3d46418eccec0f6319d2eb
Autor:
Lyubov Yu. Kanazhevskaya, Alexey A. Gorbunov, Maria V. Lukina, Denis A. Smyshliaev, Polina V. Zhdanova, Alexander A. Lomzov, Vladimir V. Koval
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 1145 (2024)
Non-heme dioxygenases of the AlkB family hold a unique position among enzymes that repair alkyl lesions in nucleic acids. These enzymes activate the Fe(II) ion and molecular oxygen through the coupled decarboxylation of the 2-oxoglutarate co-substrat
Externí odkaz:
https://doaj.org/article/854324c4930541b6af0cfd32e40ec738
Autor:
Vera A. Kostikova, Natalia V. Petrova, Tatiana M. Shaldaeva, Vladimir V. Koval, Alexander A. Chernonosov
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 18, p 13872 (2023)
By means of liquid chromatography combined with high-resolution mass spectrometry, metabolite profiling was performed on an aqueous-ethanol extract from Spiraea hypericifolia (Rosaceae) collected in Siberia (Russia). Up to 140 compounds were found in
Externí odkaz:
https://doaj.org/article/6b00b507daf74c62bf7428b17504311f
Publikováno v:
Data, Vol 8, Iss 3, p 57 (2023)
Fe(II)/2OG-dependent dioxygenases of the AlkB family catalyze a direct removal of alkylated damages in the course of DNA and RNA repair. A human homolog of the E. coli AlkB ALKBH3 protein is able to hydroxylate N1-methyladenine, N3-methylcytosine, an
Externí odkaz:
https://doaj.org/article/54a787627072499cae5acae3069d2673
Autor:
Polina V. Zhdanova, Alexander A. Ishchenko, Alexander A. Chernonosov, Dmitry O. Zharkov, Vladimir V. Koval
Publikováno v:
Data in Brief, Vol 40, Iss , Pp 107760- (2022)
This work presents new data on human endonuclease VIII-like 2 protein (hNEIL2), a part of DNA glycosylases of the helix–two-turn–helix structural superfamily. While X-ray structure of oNEIL2 (opossum Monodelphis) was resolved partially [1], the s
Externí odkaz:
https://doaj.org/article/75de9ea7c04541e68d30a3299a8f32d2
Autor:
Natalia V. Petrova, Alexander A. Chernonosov, Vladimir V. Koval, Valeriya Yu. Andreeva, Andrey S. Erst, Alexander A. Kuznetsov, Maxim S. Kulikovskiy, Wei Wang, Sheng-Xiang Yu, Vera A. Kostikova
Publikováno v:
Plants, Vol 12, Iss 2, p 381 (2023)
Spiraea hypericifolia L. is affiliated with the section Chamaedryon Ser. of the genus Spiraea L. (Rosaceae). Similar to many other Spiraea species, S. hypericifolia most often accumulates flavonols among other flavonoids, in particular quercetin and
Externí odkaz:
https://doaj.org/article/d35e1e8d61e34c4abe85def906863721
Autor:
Svetlana V. Baranova, Polina V. Zhdanova, Alexander A. Lomzov, Vladimir V. Koval, Alexander A. Chernonosov
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 22, p 13889 (2022)
Genome-editing systems, being some of the key tools of molecular biologists, represent a reasonable hope for progress in the field of personalized medicine. A major problem with such systems is their nonideal accuracy and insufficient selectivity. Th
Externí odkaz:
https://doaj.org/article/52a25fde6be0441c9995ab27cdf2d5e2