Výsledky vyhledávání - "Vladimir Ustiyan"

Akademický článek

Endothelial progenitor cells derived from embryonic stem cells prevent alveolar simplification in a murine model of bronchopulmonary dysplasia

Autor: Olena A. Kolesnichenko, Hannah M. Flood, Yufang Zhang, Vladimir Ustiyan, Hayde K. Cuervo Jimenez, Tanya V. Kalin, Vladimir V. Kalinichenko

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 11 (2023)

Introduction: Vascular remodeling and compromised alveolar development are hallmarks of chronic pulmonary diseases such as bronchopulmonary dysplasia (BPD). Despite advances in neonatal healthcare the number of BPD cases worldwide continues to increa

Externí odkaz: https://doaj.org/article/7e6cc040def643dd8fb2bf65736636c2

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Akademický článek

Endothelial progenitor cells stimulate neonatal lung angiogenesis through FOXF1-mediated activation of BMP9/ACVRL1 signaling

Autor: Guolun Wang, Bingqiang Wen, Zicheng Deng, Yufang Zhang, Olena A. Kolesnichenko, Vladimir Ustiyan, Arun Pradhan, Tanya V. Kalin, Vladimir V. Kalinichenko

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)

The molecular mechanisms through which pulmonary endothelial progenitor cells stimulate lung angiogenesis are not clear. Here, authors show that these cells stimulate the growth of alveolar capillaries and alveoli of newborn mice through FOXF1 and FL

Externí odkaz: https://doaj.org/article/b7f60e62031248e3bc0643614f405a31

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Akademický článek

Disruption of a Hedgehog-Foxf1-Rspo2 signaling axis leads to tracheomalacia and a loss of Sox9+ tracheal chondrocytes

Autor: Talia Nasr, Andrea M. Holderbaum, Praneet Chaturvedi, Kunal Agarwal, Jessica L. Kinney, Keziah Daniels, Stephen L. Trisno, Vladimir Ustiyan, John M. Shannon, James M. Wells, Debora Sinner, Vladimir V. Kalinichenko, Aaron M. Zorn

Publikováno v: Disease Models & Mechanisms, Vol 14, Iss 2 (2021)

Congenital tracheomalacia, resulting from incomplete tracheal cartilage development, is a relatively common birth defect that severely impairs breathing in neonates. Mutations in the Hedgehog (HH) pathway and downstream Gli transcription factors are

Externí odkaz: https://doaj.org/article/22d587f58b184e8ba68ff0e088f3e21b

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Akademický článek

Loss of FOXM1 in macrophages promotes pulmonary fibrosis by activating p38 MAPK signaling pathway.

Autor: Chinmayee Goda, David Balli, Markaisa Black, David Milewski, Tien Le, Vladimir Ustiyan, Xiaomeng Ren, Vladimir V Kalinichenko, Tanya V Kalin

Publikováno v: PLoS Genetics, Vol 16, Iss 4, p e1008692 (2020)

Idiopathic pulmonary fibrosis (IPF) is a chronic disease with high mortality and is refractory to treatment. Pulmonary macrophages can both promote and repress fibrosis, however molecular mechanisms regulating macrophage functions during fibrosis rem

Externí odkaz: https://doaj.org/article/7dbcd876bf614763b0b85afbe8ee1226

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Akademický článek

Lethal lung hypoplasia and vascular defects in mice with conditional Foxf1 overexpression

Autor: Avinash V. Dharmadhikari, Jenny J. Sun, Krzysztof Gogolewski, Brandi L. Carofino, Vladimir Ustiyan, Misty Hill, Tadeusz Majewski, Przemyslaw Szafranski, Monica J. Justice, Russell S. Ray, Mary E. Dickinson, Vladimir V. Kalinichenko, Anna Gambin, Paweł Stankiewicz

Publikováno v: Biology Open, Vol 5, Iss 11, Pp 1595-1606 (2016)

FOXF1 heterozygous point mutations and genomic deletions have been reported in newborns with the neonatally lethal lung developmental disorder, alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV). However, no gain-of-function m

Externí odkaz: https://doaj.org/article/f142a9f10d4e46209de988fa38a1217b

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Akademický článek

FOXM1 activates AGR2 and causes progression of lung adenomas into invasive mucinous adenocarcinomas.

Autor: David Milewski, David Balli, Vladimir Ustiyan, Tien Le, Hendrik Dienemann, Arne Warth, Kai Breuhahn, Jeffrey A Whitsett, Vladimir V Kalinichenko, Tanya V Kalin

Publikováno v: PLoS Genetics, Vol 13, Iss 12, p e1007097 (2017)

Lung cancer remains one of the most prominent public health challenges, accounting for the highest incidence and mortality among all human cancers. While pulmonary invasive mucinous adenocarcinoma (PIMA) is one of the most aggressive types of non-sma

Externí odkaz: https://doaj.org/article/ca5a0c70c4394fafa85d720bbb7ae32d

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Akademický článek

SPDEF inhibits prostate carcinogenesis by disrupting a positive feedback loop in regulation of the Foxm1 oncogene.

Autor: Xin-Hua Cheng, Markaisa Black, Vladimir Ustiyan, Tien Le, Logan Fulford, Anusha Sridharan, Mario Medvedovic, Vladimir V Kalinichenko, Jeffrey A Whitsett, Tanya V Kalin

Publikováno v: PLoS Genetics, Vol 10, Iss 9, p e1004656 (2014)

SAM-pointed domain-containing ETS transcription factor (SPDEF) is expressed in normal prostate epithelium. While its expression changes during prostate carcinogenesis (PCa), the role of SPDEF in prostate cancer remains controversial due to the lack o

Externí odkaz: https://doaj.org/article/a7b9349423df4cbf937b2064305ad569

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