Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Vladimir Temchura"'
Autor:
Jannik T. Wagner, Sandra M. Müller-Schmucker, Wenjun Wang, Philipp Arnold, Nadja Uhlig, Leila Issmail, Valentina Eberlein, Dominik Damm, Kaveh Roshanbinfar, Armin Ensser, Friederike Oltmanns, Antonia Sophia Peter, Vladimir Temchura, Silke Schrödel, Felix B. Engel, Christian Thirion, Thomas Grunwald, Manfred Wuhrer, Dirk Grimm, Klaus Überla
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract Long-acting passive immunization strategies are needed to protect immunosuppressed vulnerable groups from infectious diseases. To further explore this concept for COVID-19, we constructed Adeno-associated viral (AAV) vectors encoding the hum
Externí odkaz:
https://doaj.org/article/fb0eb88696d04de18d534ac0c445bf7a
Autor:
Riccardo Di Vincenzo, Jannis Beutel, Philipp Arnold, Yu Wang, Dominik Damm, Pierre Tannig, Anja Lux, Vladimir Temchura, Jutta Eichler, Klaus Überla
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionConformationally stabilized Env trimers have been developed as antigens for the induction of neutralizing antibodies against HIV-1. However, the non-glycosylated immunodominant base of these soluble antigens may compete with the neutraliz
Externí odkaz:
https://doaj.org/article/2571239df4064bf6a4a340badd9701ae
Autor:
Elie Richel, Jannik T. Wagner, Stephan Klessing, Riccardo Di Vincenzo, Vladimir Temchura, Klaus Überla
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundFc-fusion proteins have been successfully developed for therapeutic purposes, but are also a promising platform for the fast generation and purification of immunogens capable of inducing strong humoral immune responses in preclinical immuni
Externí odkaz:
https://doaj.org/article/fa5e0200210546b9819e91d6c35e2062
Publikováno v:
Pharmaceutics, Vol 16, Iss 1, p 24 (2023)
Infectious diseases are a predominant problem in human health. While the incidence of many pathogenic infections is controlled by vaccines, some pathogens still pose a challenging task for vaccine researchers. In order to face these challenges, the f
Externí odkaz:
https://doaj.org/article/50c000e4edd84f62831e78088731e1e1
Autor:
Vugar Azizov, Katharina Dietel, Franziska Steffen, Kerstin Dürholz, Julia Meidenbauer, Sébastien Lucas, Michael Frech, Yasunori Omata, Narges Tajik, Lisa Knipfer, Anne Kolenbrander, Silvia Seubert, Dennis Lapuente, Maria V. Sokolova, Jörg Hofmann, Matthias Tenbusch, Andreas Ramming, Ulrike Steffen, Falk Nimmerjahn, Ralf Linker, Stefan Wirtz, Martin Herrmann, Vladimir Temchura, Kerstin Sarter, Georg Schett, Mario M. Zaiss
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Moderate consumption of alcohol is associated with protection from some autoimmune diseases. Here the authors show that ethanol and its metabolite acetate can protect mice from collagen-induced arthritis and provide evidence that the mechanism of thi
Externí odkaz:
https://doaj.org/article/eeef82bd54c54d9ebcc3a76561c3042f
Autor:
Maximilian Große, Christian Setz, Pia Rauch, Janina Auth, Martina Morokutti-Kurz, Vladimir Temchura, Ulrich Schubert
Publikováno v:
Viruses, Vol 14, Iss 7, p 1404 (2022)
The ubiquitin proteasome system (UPS), particularly its deubiquitinating enzymes (DUBs), play a key role in the replication cycle of coronaviruses. The SARS-CoV-2 papain-like protease (Plpro) is known to process the viral polyproteins to form the rep
Externí odkaz:
https://doaj.org/article/7415be6efc4547eb99e082031f41ccbf
Autor:
Dominik Damm, Ehsan Suleiman, Hannah Theobald, Jannik T. Wagner, Mirjam Batzoni, Bianca Ahlfeld (née Kohlhauser), Bernd Walkenfort, Jens-Christian Albrecht, Jidnyasa Ingale, Lifei Yang, Mike Hasenberg, Richard T. Wyatt, Karola Vorauer-Uhl, Klaus Überla, Vladimir Temchura
Publikováno v:
Pharmaceutics, Vol 14, Iss 7, p 1385 (2022)
Functionalization of experimental HIV-1 virus-like particle vaccines with heterologous T helper epitopes (T helper VLPs) can modulate the humoral immune response via intrastructural help (ISH). Current advances in the conjugation of native-like HIV-1
Externí odkaz:
https://doaj.org/article/d6bcf5265dc047d3a53880797af39283
Autor:
Vladimir Temchura
Publikováno v:
Vaccines, Vol 9, Iss 3, p 273 (2021)
Despite great progress in the field of vaccine development, outbreaks of emerging pathogens and insufficient immunogenicity of some licensed vaccines call for the development of novel technologies in rational vaccine design [...]
Externí odkaz:
https://doaj.org/article/6bcb470cef09430f93fa78f4aa53baa1
Autor:
Stephan Klessing, Vladimir Temchura, Pierre Tannig, Antonia Sophia Peter, Dennis Christensen, Roland Lang, Klaus Überla
Publikováno v:
Vaccines, Vol 8, Iss 4, p 604 (2020)
The induction of a potent and long-lasting, broadly neutralizing antibody response is one of the most promising approaches in HIV-1 vaccination. Recently, we demonstrated that Gag-specific T helper cells induced by DNA priming can enhance and modulat
Externí odkaz:
https://doaj.org/article/9655ed6c06dc4fa289c9d0bb9f225e1c
Autor:
Pierre Tannig, Antonia Sophia Peter, Dennis Lapuente, Stephan Klessing, Anna Schmidt, Dominik Damm, Matthias Tenbusch, Klaus Überla, Vladimir Temchura
Publikováno v:
Vaccines, Vol 8, Iss 4, p 570 (2020)
Due to the low efficacy and the need for seasonal adaptation of currently licensed influenza A vaccines, the importance of alternative vaccination strategies is increasingly recognized. Considering that DNA vaccines can be rapidly manufactured and re
Externí odkaz:
https://doaj.org/article/80074c0243aa4d8b920c3d5c3b9515c0