Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Vladimir Sofiyev"'
Autor:
Li He, Guangyan Zhou, Vladimir Sofiyev, Eddie Garcia, Newton Nguyen, Kathy H. Li, Miriam Gochin
Publikováno v:
Viruses, Vol 14, Iss 12, p 2703 (2022)
Human Immunodeficiency virus (HIV-1) fusion is mediated by glycoprotein-41, a protein that has not been widely exploited as a drug target. Small molecules directed at the gp41 ectodomain have proved to be poorly drug-like, having moderate efficacy, h
Externí odkaz:
https://doaj.org/article/5065a82cb7664402b470a0fa6f5244e5
Autor:
Peter H. Hwang, Hardeep Kaur, Miriam Gochin, Beth A. Snyder, Priscilla A. Hogan, Roger G. Ptak, Vladimir Sofiyev
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:408-420
Low molecular weight peptidomimetic inhibitors with hydrophobic pocket binding properties and moderate fusion inhibitory activity against HIV-1 gp41-mediated cell fusion were elaborated by increasing the available surface area for interacting with th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::034d0b476ddeb0795d0fae36b274a36f
https://doi.org/10.1016/j.bmc.2016.11.010
https://doi.org/10.1016/j.bmc.2016.11.010
Publikováno v:
Chemistry – A European Journal. 18:4999-5005
The evolution of a total synthesis of the exiguamines, two structurally unusual natural products that are highly active inhibitors of indolamine-2,3-dioxygenase (IDO), is described. The ultimately successful strategy involves advanced cross-coupling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90063cc90b1929fca2af9ee4cabd030b
https://doi.org/10.1002/chem.201103605
https://doi.org/10.1002/chem.201103605
Autor:
Miriam Gochin, Priscilla A. Hogan, Beth A. Snyder, Vladimir Sofiyev, Hardeep Kaur, Roger G. Ptak, Marie K. Mankowski, Guangyan Zhou
Publikováno v:
Journal of Medicinal Chemistry
We previously described indole-containing compounds with the potential to inhibit HIV-1 fusion by targeting the hydrophobic pocket of transmembrane glycoprotein gp41. Here we report optimization and structure–activity relationship studies on the ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::960912d1f1820709ffb8641c34aa7aff
https://pubmed.ncbi.nlm.nih.gov/24856833
https://pubmed.ncbi.nlm.nih.gov/24856833
Autor:
Raamesh Deshpande, Nicole J. de Voogd, Stuart E. Turvey, Sheena C. Li, Charles Boone, Shan-Yu Fung, Chad L. Myers, Raymond J. Andersen, Vladimir Sofiyev, Julia Schneiderman, Aaron F. Hirschfeld, Jeff S. Piotrowski, Rachel E. Victor, Katherine Woods
Publikováno v:
ACS chemical biology. 9(1)
Toll-like receptors (TLRs) play a critical role in innate immunity, but activation of TLR signaling pathways is also associated with many harmful inflammatory diseases. Identification of novel anti-inflammatory molecules targeting TLR signaling pathw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65a63e4fc16ae74712dc0975b55a3199
https://pubmed.ncbi.nlm.nih.gov/24117378
https://pubmed.ncbi.nlm.nih.gov/24117378
Publikováno v:
Organic letters. 10(1)
A biomimetic synthesis of shimalactone A and B is described. Its key features are an unprecedented acid-catalyzed cyclization of a dienyl beta-ketolactone and a Stille coupling/8pi-6pi electrocyclization cascade to create the oxabicyclo[2.2.1]heptane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2333f70c7f9b9242375c1f562b87f2f6
https://pubmed.ncbi.nlm.nih.gov/18072785
https://pubmed.ncbi.nlm.nih.gov/18072785
Publikováno v:
Synfacts. 2008:0451-0451
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca4ab24f9d5498c2fb98adb302e37d03
https://doi.org/10.1055/s-2008-1072710
https://doi.org/10.1055/s-2008-1072710
Publikováno v:
Organic Letters; Jan2008, Vol. 10 Issue 1, p149-152, 4p