Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Vladimir Shalgunov"'
Autor:
Markus Staudt, Lars Hvass, Marius Müller, Rocío García-Vázquez, Jesper Tranekjær Jo̷rgensen, Vladimir Shalgunov, Umberto Maria Battisti, Andreas Kjær, Matthias M. Herth
Publikováno v:
ACS Omega, Vol 9, Iss 41, Pp 42498-42505 (2024)
Externí odkaz:
https://doaj.org/article/ebf0e50669e7435db03eabcbf74093f0
Autor:
Julie van Krimpen Mortensen, Simona Mattiussi, Lars Hvass, Emilie Graae Lund, Vladimir Shalgunov, Frank Roesch, Umberto Maria Battisti, Matthias Manfred Herth, Andreas Kjaer
Publikováno v:
Diagnostics, Vol 14, Iss 18, p 2024 (2024)
The use of fibroblast activation protein inhibitors (FAPis) for positron emission tomography (PET) imaging in cancer has garnered significant interest in recent years, yielding promising results in preclinical and clinical settings. FAP is predominan
Externí odkaz:
https://doaj.org/article/0f620831dd6c421fb00297db7f050fe5
Autor:
Klemens Egger, Frederik Gudmundsen, Naja Støckel Jessen, Christina Baun, Sandra N. Poetzsch, Vladimir Shalgunov, Matthias M. Herth, Boris B. Quednow, Chantal Martin-Soelch, Dario Dornbierer, Milan Scheidegger, Paul Cumming, Mikael Palner
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Rationale: The psychedelic effects of the traditional Amazonian botanical decoction known as ayahuasca are often attributed to agonism at brain serotonin 5-HT2A receptors by N,N-dimethyltryptamine (DMT). To reduce first pass metabolism of oral DMT, a
Externí odkaz:
https://doaj.org/article/393d530edecd42a09605e1175ed5bedd
Autor:
Vladimir Shalgunov, Mengfei Xiong, Elina T. L’Estrade, Nakul R. Raval, Ida V. Andersen, Fraser G. Edgar, Nikolaj R. Speth, Simone L. Baerentzen, Hanne D. Hansen, Lene L. Donovan, Arafat Nasser, Siv T. Peitersen, Andreas Kjaer, Gitte M. Knudsen, Stina Syvänen, Mikael Palner, Matthias M. Herth
Publikováno v:
EJNMMI Research, Vol 10, Iss 1, Pp 1-11 (2020)
Abstract Background Positron emission tomography (PET) is a molecular imaging technique that can be used to investigate the in vivo pharmacology of drugs. Initial preclinical evaluation of PET tracers is often conducted in rodents due to the accessib
Externí odkaz:
https://doaj.org/article/abd4cf9642dc46f89d08c15d1cabc529
Autor:
Sara Lopes van den Broek, Vladimir Shalgunov, Rocío García Vázquez, Natalie Beschorner, Natasha S. R. Bidesi, Maiken Nedergaard, Gitte M. Knudsen, Dag Sehlin, Stina Syvänen, Matthias M. Herth
Publikováno v:
Pharmaceuticals, Vol 15, Iss 10, p 1191 (2022)
Pretargeting is a promising nuclear imaging technique that allows for the usage of antibodies (Abs) with enhanced imaging contrast and reduced patient radiation burden. It is based on bioorthogonal chemistry with the tetrazine ligation—a reaction b
Externí odkaz:
https://doaj.org/article/2c9ae4ad9dde47ab9bbca7eb6b9872e1
Autor:
Elina Tampio L’Estrade, Fraser G. Edgar, Mengfei Xiong, Vladimir Shalgunov, Simone L. Baerentzen, Maria Erlandsson, Tomas G. Ohlsson, Mikael Palner, Gitte M. Knudsen, Matthias M. Herth
Publikováno v:
ACS Omega, Vol 4, Iss 4, Pp 7344-7353 (2019)
Externí odkaz:
https://doaj.org/article/a2f7493d2aa241d4aaf74d2a67c30505
Autor:
Rocío García-Vázquez, Jesper Tranekjær Jørgensen, Klas Erik Bratteby, Vladimir Shalgunov, Lars Hvass, Matthias M. Herth, Andreas Kjær, Umberto Maria Battisti
Publikováno v:
Pharmaceuticals, Vol 15, Iss 2, p 245 (2022)
Pretargeted PET imaging is an emerging and fast-developing method to monitor immuno-oncology strategies. Currently, tetrazine ligation is considered the most promising bioorthogonal reaction for pretargeting in vivo. Recently, we have developed a met
Externí odkaz:
https://doaj.org/article/2326c356319e40338b7af8630b691a7e
Autor:
Simone Bærentzen, Agata Casado-Sainz, Denise Lange, Vladimir Shalgunov, Isabel Martinez Tejada, Mengfei Xiong, Elina T. L’Estrade, Fraser G. Edgar, Hedok Lee, Matthias M. Herth, Mikael Palner
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Chemogenetic studies with the ligand clozapine N-oxide (CNO) are predicated upon the assumption that CNO is devoid of actions at natural neuroreceptors. However, recent evidence shows that CNO may be converted back to clozapine (CLZ) in vivo, which c
Externí odkaz:
https://doaj.org/article/551a491d81c843848396af6bd5fc1577
Autor:
Christian B. M. Poulie, Jesper T. Jørgensen, Vladimir Shalgunov, Georgios Kougioumtzoglou, Troels Elmer Jeppesen, Andreas Kjaer, Matthias M. Herth
Publikováno v:
Molecules, Vol 26, Iss 3, p 544 (2021)
Pretargeted nuclear imaging for the diagnosis of various cancers is an emerging and fast developing field. The tetrazine ligation is currently considered the most promising reaction in this respect. Monoclonal antibodies are often the preferred choic
Externí odkaz:
https://doaj.org/article/695b146362c44a5b9aa2385af6372ae4
Autor:
Natasha Bidesi, Vladimir Shalgunov, Umberto Maria Battisti, Lars Hvass, Jesper Tranekjær Jørgensen, Christian B. M. Poulie, Andreas I. Jensen, Andreas Kjaer, Matthias M. Herth
Publikováno v:
Bidesi, N, Shalgunov, V, Battisti, U M, Hvass, L, Jørgensen, J T, Poulie, C B M, Jensen, A I, Kjaer, A & Herth, M M 2023, ' Synthesis and radiolabeling of a polar [ 125 I]I-1,2,4,5-tetrazine ', Journal of Labelled Compounds and Radiopharmaceuticals, vol. 66, no. 1, pp. 22-30 . https://doi.org/10.1002/jlcr.4009
Pretargeting imaging has gained a lot of prominence, due to its excellent bioorthogonality and improved imaging contrast compared to conventional imaging. A new iodo tetrazine (Tz) derivative has been synthesized and further developed into the corres