Electrical wave propagation in an anisotropic model of the left ventricle based on analytical description of cardiac architecture.

Autor: Sergey F Pravdin, Hans Dierckx, Leonid B Katsnelson, Olga Solovyova, Vladimir S Markhasin, Alexander V Panfilov

Publikováno v: PLoS ONE, Vol 9, Iss 5, p e93617 (2014)

We develop a numerical approach based on our recent analytical model of fiber structure in the left ventricle of the human heart. A special curvilinear coordinate system is proposed to analytically include realistic ventricular shape and myofiber dir

Externí odkaz: https://doaj.org/article/41a5b583efdd4d11bc91bf4bd50397ce

Electron-conformational transformations govern the temperature dependence of the cardiac ryanodine receptor gating

Autor: Vladimir S. Markhasin, A. M. Ryvkin, Olga Solovyova, B. I. Iaparov, A. S. Moskvin

Publikováno v: JETP Letters. 102:62-68

Temperature influences many aspects of cardiac excitation-contraction coupling, in particular, hypothermia increases the open probability (Popen) of cardiac sarcoplasmic reticulum (SR) Ca2+-release channels (ryanodine-sensitive RyR channels) rising t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2de56d08f194909b5ec67ef3e164b337
https://doi.org/10.1134/s002136401513010x

Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): Standardised reporting for model reproducibility, interoperability, and data sharing

Autor: Andrew D. McCulloch, Denis Noble, Stanley Nattel, Robert S. Kass, T A Quinn, Rebecca A.B. Burton, Chris R. Johnson, Raimond L. Winslow, Gentaro Iribe, Yoram Rudy, Gregory E. Morley, Ed White, James N. Weiss, Olga Solovyova, M. Fink, Paul G.A. Volders, Ronald Wilders, Wayne R. Giles, Yung E. Earm, Ken Wang, David A. Saint, Peng Sheng Chen, Elisabetta Cerbai, András Varró, David S. Rosenbaum, Dario DiFrancesco, Itsuo Kodama, M. Egger, Emilia Entcheva, Alan Garny, Maurits A. Allessie, Stephen J. Granite, Frederick Sachs, Vladimir S. Markhasin, T. Hannes, Erich Wettwer, Leslie Tung, Rodolphe Fischmeister, Charles Antzelevitch, Ursula Ravens, Natalia A. Trayanova, Frank B. Sachse, Peter Kohl, G. Koren, Gil Bub, José Jalife, Christian Bollensdorff, Michael R. Franz, Peter Hunter, Gary R. Mirams, Igor R. Efimov, Ulrich Schotten, Satoshi Matsuoka, Mario Delmar, Sylvain Richard, Alexander V. Panfilov, Peter Taggart, Søren-Peter Olesen, Sian E. Harding, Phillip Lord

Publikováno v: Progress in biophysics and molecular biology
Progress In Biophysics & Molecular Biology
Progress in Biophysics and Molecular Biology
Progress in Biophysics & Molecular Biology, 107(1), 4-10. Elsevier Science

Cardiac experimental electrophysiology is in need of a well-defined Minimum Information Standard for recording, annotating, and reporting experimental data. As a step towards establishing this, we present a draft standard, called Minimum Information

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d0ac47281e3dd8f817cbc8b6382ec30
https://ora.ox.ac.uk/objects/uuid:e2c0a877-3450-483f-b8e2-beee19a1a50d

Mechanical interaction of heterogeneous cardiac muscle segments in silico: Effects on Ca2+ handling and action potential

Autor: Leonid B. Katsnelson, Denis Noble, Olga Solovyova, Vladimir S. Markhasin, N. A. Vikulova, Alan Garny, Peter Kohl, Penelope J. Noble

Effects of cardiac mechanical heterogeneity on the electrical function of the heart are difficult to assess experimentally, yet they pose a serious (patho-)physiological challenge. Here, we present an in silico study of the effects of mechanical hete

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e56c98778ac379ce65d809c0224e523
https://doi.org/10.1142/s0218127403008983

Cooperative mechanisms of thin filament activation and their contribution to the myocardial contractile function: Assessment in a mathematical model

Autor: Sul'man Tb, Leonid B. Katsnelson, Vladimir S. Markhasin, Olga Solovyova

Publikováno v: Biophysics. 54:39-46

A mathematical model was used for comparative analysis of the contribution to the myocardial mechanical activity of two potentially possible variants of the cooperative influence of myosin cross-bridges on calcium activation of sarcomere actin filame

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c7df1be6d8bfd725752dbf33b5d8c63e
https://doi.org/10.1134/s0006350909010072