Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Vladimir R. Babaev"'
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
BackgroundRictor is an essential component of mammalian target of rapamycin (mTOR) complex 2 (mTORC2), a conserved serine/threonine kinase that may play a role in cell proliferation, survival and innate or adaptive immune responses. Genetic loss of R
Externí odkaz:
https://doaj.org/article/44f10e431c044119b83b2aca678f361a
Autor:
Huan Tao, Patricia G. Yancey, Vladimir R. Babaev, John L. Blakemore, Youmin Zhang, Lei Ding, Sergio Fazio, MacRae F. Linton
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 8, Pp 1449-1460 (2015)
Macrophage apoptosis and efferocytosis are key determinants of atherosclerotic plaque inflammation and necrosis. Bone marrow transplantation studies in ApoE- and LDLR-deficient mice revealed that hematopoietic scavenger receptor class B type I (SR-BI
Externí odkaz:
https://doaj.org/article/9b17830fd5914ea284743f5ba4a14312
Autor:
Vladimir R. Babaev, Katie E. Hebron, Carrie B. Wiese, Cynthia L. Toth, Lei Ding, Youmin Zhang, James M. May, Sergio Fazio, Kasey C. Vickers, MacRae F. Linton
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 11, Pp 2296-2308 (2014)
Macrophages play crucial roles in the formation of atherosclerotic lesions. Akt, a serine/threonine protein kinase B, is vital for cell proliferation, migration, and survival. Macrophages express three Akt isoforms, Akt1, Akt2, and Akt3, but the role
Externí odkaz:
https://doaj.org/article/4da4d555f5614ee7ad4c847bf68c2fb8
Autor:
Patricia G. Yancey, Jerome W. Gray, Yu Hong, Evelyn E. Griffin, Brian E. Cox, Vladimir R. Babaev, Fazio Sergio, MacRae F. Linton
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 5, Pp 1140-1149 (2007)
Mice deficient in scavenger receptor class B type I (SR-BI) and apolipoprotein E (apoE) [double knockout (DKO) mice] develop dyslipidemia, accelerated atherosclerosis, and myocardial infarction, and die prematurely. We examined effects of apoE and SR
Externí odkaz:
https://doaj.org/article/54b3fc1c03144d48aa1247112dd46d2f
Autor:
Sergio Fazio, Vladimir R. Babaev, Michael E. Burleigh, Amy S. Major, Alyssa H. Hasty, MacRae F. Linton
Publikováno v:
Journal of Lipid Research, Vol 43, Iss 10, Pp 1602-1609 (2002)
We have previously reported that the introduction of macrophage apoE into mice lacking both apoE and the LDL receptor (apoE−/−/LDLR−/−) through bone marrow transplantation (apoE+/+/LDLR−/−→apoE−/−/LDLR−/−) produces progressive a
Externí odkaz:
https://doaj.org/article/5826c333508642fca32b5fd98b2782e0
Autor:
Kasey C. Vickers, Youmin Zhang, Vladimir R. Babaev, MacRae F. Linton, James M. May, Stephen A. Ramsey, Lei Ding
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 39:156-169
Objective— Macrophages express 3 Akt (protein kinase B) isoforms, Akt1, Akt2, and Akt3, which display isoform-specific functions but may be redundant in terms of Akt survival signaling. We hypothesize that loss of 2 Akt isoforms in macrophages will
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6d1068ef2d45c91b06c6b09f7dd8506
https://doi.org/10.1161/atvbaha.118.312206
https://doi.org/10.1161/atvbaha.118.312206
Autor:
Adam G. Whitney, Matthew L. Steinhauser, Jonathan D. Brown, Vladimir R. Babaev, MacRae F. Linton, Christelle Guillermier, Sean P. Doherty
Publikováno v:
JCI Insight. 4
Atherosclerotic plaques feature local proliferation of leukocytes and vascular smooth muscle cells (VSMCs) and changes in cellular metabolism. Yet the relationship between glucose utilization and proliferation has been technically impossible to study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a1922813dac01fa94ed90f83af8801b
https://doi.org/10.1172/jci.insight.128528
https://doi.org/10.1172/jci.insight.128528
Autor:
Huan Tao, Edward F Linton, Vladimir R. Babaev, Jiansheng Huang, Patricia G. Yancey, MacRae F. Linton
Publikováno v:
Circulation Journal. 80:2259-2268
Macrophage apoptosis and the ability of macrophages to clean up dead cells, a process called efferocytosis, are crucial determinants of atherosclerosis lesion progression and plaque stability. Environmental stressors initiate endoplasmic reticulum (E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74227943c08ab4ff279cb0b554df1278
https://doi.org/10.1253/circj.cj-16-0924
https://doi.org/10.1253/circj.cj-16-0924
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Background Rictor is an essential component of mammalian target of rapamycin (mTOR) complex 2 (mTORC2), a conserved serine/threonine kinase that may play a role in cell proliferation, survival and innate or adaptive immune responses. Genetic loss of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6d0aa401534c1da2eaf59f30ae2f200
https://doi.org/10.3389/fimmu.2018.00215
https://doi.org/10.3389/fimmu.2018.00215
Autor:
Vladimir R, Babaev, Jiansheng, Huang, Lei, Ding, Youmin, Zhang, James M, May, MacRae F, Linton
Publikováno v:
Frontiers in Immunology
Background Rictor is an essential component of mammalian target of rapamycin (mTOR) complex 2 (mTORC2), a conserved serine/threonine kinase that may play a role in cell proliferation, survival and innate or adaptive immune responses. Genetic loss of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bdd7b5f0aa30d178a65e3c4ad135ee97
https://pubmed.ncbi.nlm.nih.gov/29487597
https://pubmed.ncbi.nlm.nih.gov/29487597