Zobrazeno 1 - 10
of 319
pro vyhledávání: '"Vladimir R Muzykantov"'
Autor:
John C Greenwood, Fatima M Talebi, David H Jang, Audrey E Spelde, Todd J Kilbaugh, Frances S Shofer, Michael A Acker, John G T Augoustides, Jan Bakker, Nuala J Meyer, Jacob S Brenner, Vladimir R Muzykantov, Benjamin S Abella
Publikováno v:
PLoS ONE, Vol 17, Iss 8, p e0273349 (2022)
BackgroundDespite current resuscitation strategies, circulatory shock and organ injury after cardiac surgery occur in 25-40% of patients. Goal-directed resuscitation after cardiac surgery has generated significant interest, but clinical practice to n
Externí odkaz:
https://doaj.org/article/2e54534205ad4bdcb892d4e97d6be908
Autor:
Raisa Kiseleva, Colin F Greineder, Carlos H Villa, Elizabeth D Hood, Vladimir V Shuvaev, Jing Sun, Ann-Marie Chacko, Valsamma Abraham, Horace M DeLisser, Vladimir R Muzykantov
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169537 (2017)
Monoclonal antibodies (mAbs) directed to extracellular epitopes of human and mouse Platelet Endothelial Cell Adhesion Molecule-1 (CD31 or PECAM-1) stimulate binding of other mAbs to distinct adjacent PECAM-1 epitopes. This effect, dubbed Collaborativ
Externí odkaz:
https://doaj.org/article/9155c748285141548f446cfe89f90dc4
Autor:
M Carme Coll Ferrer, Vladimir V Shuvaev, Blaine J Zern, Russell J Composto, Vladimir R Muzykantov, David M Eckmann
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102329 (2014)
Lysozyme dextran nanogels (NG) have great potential in vitro as a drug delivery platform, combining simple chemistry with rapid uptake and cargo release in target cells with "stealth" properties and low toxicity. In this work, we study for the first
Externí odkaz:
https://doaj.org/article/5e39f1d9f7e24a8bb220d96a423d3607
Autor:
Hamideh Parhiz, Vladimir V. Shuvaev, Qin Li, Tyler E. Papp, Awurama A. Akyianu, Ruiqi Shi, Amir Yadegari, Hamna Shahnawaz, Sean C. Semple, Barbara L. Mui, Drew Weissman, Vladimir R. Muzykantov, Patrick M. Glassman
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102175- (2024)
RNA therapeutics are an emerging, powerful class of drugs with potential applications in a wide range of disorders. A central challenge in their development is the lack of clear pharmacokinetic (PK)-pharmacodynamic relationship, in part due to the si
Externí odkaz:
https://doaj.org/article/7f789f117b494a00a874576d1146347e
Autor:
Vladimir V Shuvaev, Jingyan Han, Samira Tliba, Evguenia Arguiri, Melpo Christofidou-Solomidou, Servio H Ramirez, Holly Dykstra, Yuri Persidsky, Dmitriy N Atochin, Paul L Huang, Vladimir R Muzykantov
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77002 (2013)
Pro-inflammatory activation of vascular endothelium is implicated in pathogenesis of severe conditions including stroke, infarction and sepsis. We have recently reported that superoxide dismutase (SOD) conjugated with antibodies (Ab/SOD) that provide
Externí odkaz:
https://doaj.org/article/394d1782bbd244f4af6bb830beeb475e
Autor:
Colin F Greineder, Ann-Marie Chacko, Sergei Zaytsev, Blaine J Zern, Ronald Carnemolla, Elizabeth D Hood, Jingyan Han, Bi-Sen Ding, Charles T Esmon, Vladimir R Muzykantov
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80110 (2013)
The use of targeted therapeutics to replenish pathologically deficient proteins on the luminal endothelial membrane has the potential to revolutionize emergency and cardiovascular medicine. Untargeted recombinant proteins, like activated protein C (A
Externí odkaz:
https://doaj.org/article/5b46ccfab9ca479b9559e7eb89df9a94
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34958 (2012)
Antibodies to platelet endothelial cell adhesion molecule-1 (PECAM-1) facilitate targeted drug delivery to endothelial cells by "vascular immunotargeting." To define the targeting quantitatively, we investigated the endothelial binding of monoclonal
Externí odkaz:
https://doaj.org/article/1bd6ddcf87c94f36979ca7459425613c
Autor:
Brian M. Leonard, Vladimir V. Shuvaev, Trent A. Bullock, Kalpani N. Udeni Galpayage Dona, Vladimir R. Muzykantov, Allison M. Andrews, Servio H. Ramirez
Publikováno v:
Bioengineering, Vol 11, Iss 3, p 200 (2024)
The neuroinflammatory cascade triggered by traumatic brain injury (TBI) represents a clinically important point for therapeutic intervention. Neuroinflammation generates oxidative stress in the form of high-energy reactive oxygen and nitrogen species
Externí odkaz:
https://doaj.org/article/fc46f6c9b1954fa8b6e78fbee33f10a7
Autor:
Sahily Reyes-Esteves, Jia Nong, Patrick M. Glassman, Serena Omo-Lamai, Sarah Ohashi, Jacob W. Myerson, Marco E. Zamora, Xiaonan Ma, Scott E. Kasner, Lauren Sansing, Vladimir R. Muzykantov, Oscar A. Marcos-Contreras, Jacob S. Brenner
Publikováno v:
Journal of Controlled Release. 356:185-195
Autor:
Carlos H. Villa, Daniel C. Pan, Ian H. Johnston, Colin F. Greineder, Landis R. Walsh, Elizabeth D. Hood, Douglas B. Cines, Mortimer Poncz, Don L. Siegel, Vladimir R. Muzykantov
Publikováno v:
Blood Advances, Vol 2, Iss 3, Pp 165-176 (2018)
Abstract: Carriage of drugs by red blood cells (RBCs) modulates pharmacokinetics, pharmacodynamics, and immunogenicity. However, optimal targets for attaching therapeutics to human RBCs and adverse effects have not been studied. We engineered nonhuma
Externí odkaz:
https://doaj.org/article/a2921fc5daff4bd8bbb9bbefa4a0a492