Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Vladimir Pogorelov"'
Autor:
Maximiliano Rapanelli, Rivka C. Schwarcz, Christopher Pittenger, Kyla D. Horn, Vladimir Pogorelov, Luciana Romina Frick, Angus C. Nairn
Publikováno v:
Journal of Biological Chemistry. 291:21042-21052
The basal ganglia have a central role in motor patterning, habits, motivated behaviors, and cognition as well as in numerous neuropsychiatric disorders. Receptors for histamine, especially the H3 receptor (H3R), are highly expressed in the striatum,
Autor:
Mikhail V. Pletnikov, Bruno Jedynak, William B. Mathews, Jongho Kim, Daniel P. Holt, Luewi Zhou, Vladimir Pogorelov, Hayden T. Ravert, Robert F. Dannals, Atsushi Kamiya, Andrew G. Horti, Dean F. Wong, James Robert Brašić, Heather Valentine
Publikováno v:
Molecular Imaging and Biology. 17:355-363
Disrupted-in-schizophrenia-1 (DISC1) is a promising genetic susceptibility factor for major psychiatric conditions, such as schizophrenia. We hypothesized that the mutant DISC1 alters the homeostasis of multi-receptor interactions between dopaminergi
Autor:
Kristie T. Ota, Maximiliano Rapanelli, Hiroshi Ohtsu, Luciana Romina Frick, Christopher Pittenger, Vladimir Pogorelov, Eeman Abbasi
Publikováno v:
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 24(12)
Tic disorders produce substantial morbidity, but their pathophysiology remains poorly understood. Convergent evidence suggests that dysregulation of the cortico-basal ganglia circuitry is central to the pathogenesis of tics. Tourette syndrome (TS), t
Publikováno v:
Experimental neurology. 265
The pathophysiology of the tics that define Gilles de la Tourette syndrome (TS) is not well understood. Local disinhibition within the striatum has been hypothesized to play a pathogenic role. In support of this, experimental disinhibition by local a
Autor:
Maximiliano Rapanelli, A. Gulhan Ercan-Sencicek, Eileen Billingslea, Bennett L. Leventhal, Matthew W. State, Christopher Pittenger, Jean-Dominique Gallezot, Suzanne Wasylink, Zoë A. Hughes, Yu-Shin Ding, Kaitlyn E. Panza, Lissandra Castellan Baldan, George M. Anderson, Ivan E. de Araujo, Kyle A. Williams, Roxanne R Gorczyca, Linda C. Mayes, Hiroshi Ohtsu, Vladimir Pogorelov, Erin Loring, John H. Krystal, Michael H. Bloch, Kuakarun Krusong, Michael J. Crowley
Publikováno v:
Neuron, vol 81, iss 1
SummaryTourette syndrome (TS) is characterized by tics, sensorimotor gating deficiencies, and abnormalities of cortico-basal ganglia circuits. A mutation in histidine decarboxylase (Hdc), the key enzyme for the biosynthesis of histamine (HA), has bee