Výsledky vyhledávání - "Vladimir Petrow"

Angiostatic activities of medroxyprogesterone acetate and its analogues

Autor: Nobuyuki Terada, Takashi Yamamoto, Yasuko Nishizawa, Vladimir Petrow

Publikováno v: International Journal of Cancer. 56:393-399

The effects of medroxyprogesterone acetate (MPA) (I) and related compounds (II-VI) upon angiogenesis induced by basic fibroblast growth factor (bFGF) or transforming growth factor-alpha (TGF-alpha) were investigated using a rabbit corneal system for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::813e7c2caa070e15fb14e94cba1828e7
https://doi.org/10.1002/ijc.2910560318

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1-Dehydro-melengestrol acetate inhibitis the growth and protein kinase C activity of androgen-independent Dunning rat prostatic tumors

Autor: George M. Padilla, Vladimir Petrow, Michael J. Battistone

Publikováno v: Cancer Chemotherapy and Pharmacology. 31:407-411

Androgen-independent Dunning R3327-AT3 rat prostate tumors are considered an appropriate model of advanced prostate cancer in humans. We recently reported that the progestational steroid melengestrol acetate (MGA) inhibited growth of these tumors on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d7bc55d908562f288c805539f35ef2a
https://doi.org/10.1007/bf00686156

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LY207320 (6-methylene-4-pregnene-3,20-dione) inhibits testosterone biosynthesis, androgen uptake, 5α-reductase, and produces prostatic regression in male rats

Autor: Dennis M. Hoover, Thomas R. Blohm, Blake Lee Neubauer, Nancy B. Stamm, E. Barry Smalstig, Richard E. Toomey, Marie E. Laughlin, Kevin L. Best, Kenneth Steven Hirsch, Cynthia A. Gates, Robin L. Goode, Vladimir Petrow

Publikováno v: The Prostate. 23:181-199

LY207320 is an in vitro inhibitor (estimated IC50 = 0.06 microM) of steroid 5 alpha-reductase that catalyzes the conversion of testosterone (T) to dihydrotestosterone (DHT). In contrast, LY207320 was only moderately active against rat prostatic 5 alp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b193804edd54162c1cfab93690bc31d
https://doi.org/10.1002/pros.2990230302

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Inhibition of Experimentally Induced Mouse Prostatic Hyperplasia by Castration or Steroid Antagonist Administration1

Autor: Leland W.K. Chung, Blake Lee Neubauer, Vladimir Petrow, Robert A. Sikes, Sharon Thomsen

Publikováno v: Biology of Reproduction. 43:353-362

Mouse prostatic hyperplasia has been induced experimentally by implanting fetalurogenital sinus tissue into the prostate gland of syngeneic mice. We compared the effects of castration and steroid antagonist administration on the growth of the prostat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8081a42f3f146d61cfba725ae3f959d1
https://doi.org/10.1095/biolreprod43.2.353

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A history of steroid chemistry: Some contributions from European industry, foreword

Autor: Vladimir Petrow

Publikováno v: Steroids. 61:473-475

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b6192a7e5c9c17eeaa9e0ea8cc269833
https://doi.org/10.1016/0039-128x(96)00127-4

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19-Aldehydo-4-androstene-3,17-dione: An estrogen precursor that inhibits sebaceous secretion in a rat model

Autor: G. Ebling, Vladimir Petrow, F. John

Publikováno v: Journal of Investigative Dermatology. 101:S121-S123

19-aldehydo-4-androstene-3,17-dione (A; R = CHO), a biogenetic precursor of estrone in the body, has been found to suppress sebum secretion in the ovariectomized testosterone-treated Wistar rat at 1/2000 times the dose of cyproterone acetate required

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4fed449a62e58e8fa584e2603d654e20
https://doi.org/10.1016/0022-202x(93)90511-f

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The rise and fall of the British Drug Houses, Ltd

Autor: Frank Hartley, Vladimir Petrow

Publikováno v: Steroids. 61(8)

Steroid research at BDH began in earnest in 1946-1948, when Hartley and Petrow joined the company. With the need to find new progestational agents to replace ethisterone and progesterone, the company began work. They were the first to discover the vi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d81160d15c655d67d877847496ca37b5
https://pubmed.ncbi.nlm.nih.gov/8870168

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6-Methylene progesterone is cytotoxic to human cancer cell lines independent of its 5-alpha-reductase activity

Autor: Cary N. Robertson, Vladimir Petrow, George M. Padilla, Kathryn M. Roberson, J M Schmidt

Publikováno v: The Prostate. 26(1)

This investigation examined the effects of 6-methylene progesterone (6MP), an irreversible inhibitor of 5-alpha-reductase, on prostatic cancer (PC) cell lines. Dose titration microculture tetrazolium assays were used to evaluate cytotoxicity in cultu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66f84af78a53a36431efb22fe26680c4
https://pubmed.ncbi.nlm.nih.gov/7845864

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Effects of 6-methylene progesterone on growth, morphology, and blood flow of the Dunning R3327 prostatic adenocarcinoma

Autor: Jan-Erik Damber, Maréne Landström, L. Daehlin, Anders Bergh, Vladimir Petrow

Publikováno v: The Prostate. 20(3)

Copenhagen x Fisher F1 rats were implanted with the androgen-dependent Dunning R3327 prostatic adenocarcinoma. When the tumors had median volumes of ca 470 mm3, the rats were castrated and/or treated with 6-methylene-4-pregnene-3,20-dione (6MP) in di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69742b88247d663f5cea6cd4d34456c5
https://pubmed.ncbi.nlm.nih.gov/1574466

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