Blatchford Score Is Superior to AIMS65 Score in Predicting the Need for Clinical Interventions in Elderly Patients with Nonvariceal Upper Gastrointestinal Bleed

Autor: Khalid Abusaada, Fnu Asad-ur-Rahman, Vladimir Pech, Umair Majeed, Shengchuan Dai, Xiang Zhu, Sally A. Litherland

Publikováno v: Advances in Medicine, Vol 2016 (2016)

Background. Blatchford and AIMS65 scores were developed to risk stratify patients with upper gastrointestinal bleed (UGIB). We sought to assess the performance of Blatchford and AIMS65 scores in predicting outcomes in elderly patients with nonvaricea

Externí odkaz: https://doaj.org/article/ff450ac696b641e99fb8eb8af908bdc7

Contractile force is enhanced in Aortas from pendrin null mice due to stimulation of angiotensin II-dependent signaling.

Autor: Roy L Sutliff, Erik R Walp, Young Hee Kim, Lori A Walker, Alexander M El-Ali, Jing Ma, Robert Bonsall, Semra Ramosevac, Douglas C Eaton, Jill W Verlander, Laura Hansen, Rudolph L Gleason, Truyen D Pham, Seongun Hong, Vladimir Pech, Susan M Wall

Publikováno v: PLoS ONE, Vol 9, Iss 8, p e105101 (2014)

Pendrin is a Cl-/HCO3- exchanger expressed in the apical regions of renal intercalated cells. Following pendrin gene ablation, blood pressure falls, in part, from reduced renal NaCl absorption. We asked if pendrin is expressed in vascular tissue and

Externí odkaz: https://doaj.org/article/bb1451a941eb423ba64bad8a0b856ab8

The Role of Intercalated Cell Nedd4-2 in BP Regulation, Ion Transport, and Transporter Expression

Autor: Baoli Yang, Karen I. López-Cayuqueo, Truyen D. Pham, Janet D. Klein, Xiaonan H. Wang, Annie Y. Park, Régine Chambrey, Young Hee Kim, Roy L. Sutliff, Masayoshi Nanami, Olivier Staub, Susan M. Wall, Jill W. Verlander, Vladimir Pech

Publikováno v: Journal of the American Society of Nephrology, vol. 29, no. 6, pp. 1706-1719
Journal of the American Society of Nephrology
Journal of the American Society of Nephrology, American Society of Nephrology, 2018, 29 (6), pp.1706-1719. ⟨10.1681/ASN.2017080826⟩

BackgroundNedd4-2 is an E3 ubiquitin-protein ligase that associates with transport proteins, causing their ubiquitylation, and then internalization and degradation. Previous research has suggested a correlation between Nedd4-2 and BP. In this study,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::147ce3c6e9d2d9c4608ed2ad40c2d739
https://serval.unil.ch/notice/serval:BIB_A3FC0F6C0BF9

ENaC inhibition stimulates Cl- secretion in the mouse cortical collecting duct through an NKCC1-dependent mechanism

Autor: Young-Hee Kim, Diana Agazatian, Bernard C. Rossier, Susan M. Wall, Alan M. Weinstein, Vladimir Pech, Masayoshi Nanami, Monika Thumova, Edith Hummler

Publikováno v: American Journal of Physiology. Renal physiology

In cortical collecting ducts (CCDs) perfused in vitro, inhibiting the epithelial Na+channel (ENaC) reduces Cl−absorption. Since ENaC does not transport Cl−, the purpose of this study was to determine how ENaC modulates Cl−absorption. Thus, Cl�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2389238827683d860702cac24e7a1911
http://www.ncbi.nlm.nih.gov/pubmed/22496413

Role of pendrin in iodide balance: going with the flow

Autor: Christine Baylis, William H. Beierwaltes, Young-Hee Kim, Wencui Zheng, Donna B. Farley, Lewis E. Braverman, Susan M. Wall, Jill W. Verlander, Seongun Hong, Vladimir Pech, Truyen D. Pham

Publikováno v: American Journal of Physiology-Renal Physiology. 297:F1069-F1079

Pendrin is expressed in the apical regions of type B and non-A, non-B intercalated cells, where it mediates Cl−absorption and HCO3−secretion through apical Cl−/HCO3−exchange. Since pendrin is a robust I−transporter, we asked whether pendrin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13fb82575a73222162e403e19527a19f
https://doi.org/10.1152/ajprenal.90581.2008