Zobrazeno 1 - 3
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pro vyhledávání: '"Vladimir P. Magloire"'
Publikováno v:
Tetrahedron: Asymmetry. 15:3005-3009
Use of solid-supported reagents simplified routine acylation of primary and secondary alcohols because it eliminated traditional purification. Using a parallel synthesizer, eight primary or secondary alcohols reacted with acid chloride in the presenc
Publikováno v:
Journal of the American Chemical Society. 127(7)
We report the first biocatalytic route to sulfinamides (R-S(O)-NH2), whose sulfur stereocenter makes them important chiral auxiliaries for the asymmetric synthesis of amines. Subtilisin E did not catalyze hydrolysis of N-acetyl or N-butanoyl arylsulf
Publikováno v:
Journal of the American Chemical Society. 127:6536-6537
Subtilisin Carlsberg-catalyzed hydrolysis of N-chloroacetyl p-toluenesulfinamide favored cleavage of the sulfinamide (S(O)-N) bond with a minor amount ( approximately 25%) of the expected carboxamide (C(O)-N) bond. The sulfinamide hydrolysis was enan