Alternative Animal Models of Aging Research

Autor: Susanne Holtze, Ekaterina Gorshkova, Stan Braude, Alessandro Cellerino, Philip Dammann, Thomas B. Hildebrandt, Andreas Hoeflich, Steve Hoffmann, Philipp Koch, Eva Terzibasi Tozzini, Maxim Skulachev, Vladimir P. Skulachev, Arne Sahm

Publikováno v: Frontiers in Molecular Biosciences, Vol 8 (2021)

Most research on mechanisms of aging is being conducted in a very limited number of classical model species, i.e., laboratory mouse (Mus musculus), rat (Rattus norvegicus domestica), the common fruit fly (Drosophila melanogaster) and roundworm (Caeno

Externí odkaz: https://doaj.org/article/6ee18a652b7f4283a8c8e75e4184a1c3

Mitochondria in the Nuclei of Rat Myocardial Cells

Autor: Chupalav M. Eldarov, Irina M. Vangely, Valeriya B. Vays, Eugene V. Sheval, Susanne Holtze, Thomas B. Hildebrandt, Natalia G. Kolosova, Vasily A. Popkov, Egor Y. Plotnikov, Dmitry B. Zorov, Lora E. Bakeeva, Vladimir P. Skulachev

Publikováno v: Cells, Vol 9, Iss 3, p 712 (2020)

Electron microscopic study of cardiomyocytes taken from healthy Wistar and OXYS rats and naked mole rats (Heterocephalus glaber) revealed mitochondria in nuclei that lacked part of the nuclear envelope. The direct interaction of mitochondria with nuc

Externí odkaz: https://doaj.org/article/6d470851b08e4f2e9eb1de28ea8bcf3c

Neuroprotective Effects of Mitochondria-Targeted Plastoquinone and Thymoquinone in a Rat Model of Brain Ischemia/Reperfusion Injury

Autor: Denis N. Silachev, Egor Y. Plotnikov, Ljubava D. Zorova, Irina B. Pevzner, Natalia V. Sumbatyan, Galina A. Korshunova, Mikhail V. Gulyaev, Yury A. Pirogov, Vladimir P. Skulachev, Dmitry B. Zorov

Publikováno v: Molecules, Vol 20, Iss 8, Pp 14487-14503 (2015)

We explored the neuroprotective properties of natural plant-derived antioxidants plastoquinone and thymoquinone (2-demethylplastoquinone derivative) modified to be specifically accumulated in mitochondria. The modification was performed through chemi

Externí odkaz: https://doaj.org/article/f8a7d86faa9a4f91b58f4b66e549e72b

Mitochondrial Damage and Mitochondria-Targeted Antioxidant Protection in LPS-Induced Acute Kidney Injury

Autor: Egor Y. Plotnikov, Irina B. Pevzner, Ljubava D. Zorova, Valery P. Chernikov, Andrey N. Prusov, Igor I. Kireev, Denis N. Silachev, Vladimir P. Skulachev, Dmitry B. Zorov

Publikováno v: Antioxidants, Vol 8, Iss 6, p 176 (2019)

Induced and frequently unwanted alterations in the mitochondrial structure and functions are a key component of the pathological cascade in many kidney pathologies, including those associated with acute damage. One of the principal pathogenic element

Externí odkaz: https://doaj.org/article/ab09a3f81da04e9e8518a5d63ae6aa57

Mild depolarization of the inner mitochondrial membrane is a crucial component of an anti-aging program

Autor: Alisa A. Panteleeva, Thomas B. Hildebrandt, O. A. Averina, Vladimir P. Skulachev, Mikhail Yu. Vyssokikh, Roman A. Zinovkin, Nicolas Fasel, Fedor F. Severin, Konstantin G. Lyamzaev, M. V. Marey, Susanne Holtze, Maxim V. Skulachev

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 117(12):6491-6501
Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 12, pp. 6491-6501

Significance The mitochondria, organelles that produce the largest amounts of ATP and reactive oxygen species (mROS) in living cells, are equipped with a universal mechanism that can completely prevent mROS production. This mechanism consists of mild

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f267a8d977cf1edb336ec301038aa522
https://doi.org/10.1073/pnas.1916414117