Zobrazeno 1 - 10
of 137
pro vyhledávání: '"Vladimir Novitsky"'
Autor:
Akarsh Manne, Alexander DeLong, Winstone Nyandiko, Allison K. DeLong, Rachel Vreeman, Vladimir Novitsky, Anthony Ngeresa, Edwin Sang, Ashley Chory, Josephine Aluoch, Eslyne Jepkemboi, Millicent Orido, Celestine Ashimosi, Festus Sang, Joseph W. Hogan, Rami Kantor
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 2 (2022)
ABSTRACT HIV-1 drug resistance remains a global challenge, yet access to testing is limited, particularly in resource-limited settings. We examined feasibility and limitations of genotyping using dried filter analytes in treatment-experienced Kenyan
Externí odkaz:
https://doaj.org/article/8781dcde00744d3fb11aa22caf10a7f2
Autor:
Monkgomotsi J. Maseng, BSc, Leabaneng Tawe, PhD, Prisca K. Thami, PhD, Sikhulile Moyo, PhD, Ishmael Kasvosve, PhD, Vladimir Novitsky, PhD, Max Essex, PhD, Gianluca Russo, PhD, Simani Gaseitsiwe, PhD, Giacomo M. Paganotti, PhD, Jorddy Neves Cruz.
Publikováno v:
Medicine, Vol 101, Iss 17, p e29066 (2022)
Abstract. The two non-nucleoside reverse transcriptase inhibitors (NNRTIs), efavirenz (EFV) and nevirapine (NVP), are currently the core antiretroviral drugs for treatment of HIV in sub-Saharan Africa including Botswana. The drugs are metabolized by
Externí odkaz:
https://doaj.org/article/cfd885a8c22c47e2b69ba1852ada6668
Autor:
Lerato E Magosi, Yinfeng Zhang, Tanya Golubchik, Victor DeGruttola, Eric Tchetgen Tchetgen, Vladimir Novitsky, Janet Moore, Pam Bachanas, Tebogo Segolodi, Refeletswe Lebelonyane, Molly Pretorius Holme, Sikhulile Moyo, Joseph Makhema, Shahin Lockman, Christophe Fraser, Myron Max Essex, Marc Lipsitch, On behalf of The Botswana Combination Prevention Project and PANGEA consortium
Publikováno v:
eLife, Vol 11 (2022)
Background: Mathematical models predict that community-wide access to HIV testing-and-treatment can rapidly and substantially reduce new HIV infections. Yet several large universal test-and-treat HIV prevention trials in high-prevalence epidemics dem
Externí odkaz:
https://doaj.org/article/8133e598aa0b4adf86f7f146f59a8afc
Autor:
Kaelo K. Seatla, Dorcas Maruapula, Wonderful T. Choga, Olorato Morerinyane, Shahin Lockman, Vladimir Novitsky, Ishmael Kasvosve, Sikhulile Moyo, Simani Gaseitsiwe
Publikováno v:
Pathogens, Vol 10, Iss 8, p 1027 (2021)
Dolutegravir (DTG) is a potent anti-HIV drug that is used to treat HIV globally. There have been reports of mutations in the HIV-1 3′-polypurine tract (3′PPT) of the nef gene, contributing to DTG failure; however, there are limited ‘real-world
Externí odkaz:
https://doaj.org/article/2d84670cbd144b679e3c819e3e0bfcef
Autor:
Tafireyi Marukutira, Lisa Block, Mary Grace Alwano, Stephanie Behel, Joseph N Jarvis, Unoda Chakalisa, Kate Powis, Vladimir Novitsky, William Bapati, Huisheng Wang, Faith Ussery, Refeletswe Lebelonyane, Lisa A Mills, Janet Moore, Pamela Bachanas
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0221629 (2019)
IntroductionNon-citizens often face barriers to HIV care and treatment. Quantifying knowledge of positive HIV status and antiretroviral therapy (ART) coverage among non-citizens in a high HIV-prevalence country like Botswana that is close to achievin
Externí odkaz:
https://doaj.org/article/77ef2fc1d0334364b47d2ec2f9706f12
Autor:
Tuelo Mogashoa, Pinkie Melamu, Serej D Ley, Elizabeth M Streicher, Thato Iketleng, Nametso Kelentse, Lucy Mupfumi, Margaret Mokomane, Botshelo Kgwaadira, Vladimir Novitsky, Ishmael Kasvosve, Sikhulile Moyo, Robin M Warren, Simani Gaseitsiwe
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0216306 (2019)
BackgroundMolecular typing of Mycobacterium tuberculosis (M.tb) isolates can inform Tuberculosis (TB) control programs on the relative proportion of transmission driving the TB epidemic. There is limited data on the M. tb genotypes that are circulati
Externí odkaz:
https://doaj.org/article/5ffe4653fbaa4b5290826332ce0afbcc
Autor:
Sikhulile Moyo, Eduan Wilkinson, Vladimir Novitsky, Alain Vandormael, Simani Gaseitsiwe, Max Essex, Susan Engelbrecht, Tulio de Oliveira
Publikováno v:
Viruses, Vol 7, Iss 10, Pp 5508-5524 (2015)
In this paper, we review serological and molecular based methods to identify HIV infection recency. The accurate identification of recent HIV infection continues to be an important research area and has implications for HIV prevention and treatment i
Externí odkaz:
https://doaj.org/article/b8d9bd6f3dd04aa3b2105545073ab9eb
Autor:
Sikhulile Moyo, Alain Vandormael, Eduan Wilkinson, Susan Engelbrecht, Simani Gaseitsiwe, Kenanao P Kotokwe, Rosemary Musonda, Frank Tanser, Max Essex, Vladimir Novitsky, Tulio de Oliveira
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0160649 (2016)
BACKGROUND:Cross-sectional, biomarker methods to determine HIV infection recency present a promising and cost-effective alternative to the repeated testing of uninfected individuals. We evaluate a viral-based assay that uses a measure of pairwise dis
Externí odkaz:
https://doaj.org/article/7afeb4c2ef8643bcb5b824d6a60dfbc6
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0135469 (2015)
Analyses of viral genetic linkage can provide insight into HIV transmission dynamics and the impact of prevention interventions. For example, such analyses have the potential to determine whether recently-infected individuals have acquired viruses ci
Externí odkaz:
https://doaj.org/article/17cb6bb0f0684cdf8da7135a90c4f7bc
Autor:
Ireen E Kiwelu, Vladimir Novitsky, Elimsaada Kituma, Lauren Margolin, Jeannie Baca, Rachel Manongi, Noel Sam, John Shao, Mary F McLane, Saidi H Kapiga, M Essex
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102258 (2014)
A national ART program was launched in Tanzania in October 2004. Due to the existence of multiple HIV-1 subtypes and recombinant viruses co-circulating in Tanzania, it is important to monitor rates of drug resistance. The present study determined the
Externí odkaz:
https://doaj.org/article/a75bdade6ac940709c671ff6fabdf4b9