Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Vladimir Nigrovic"'
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 85:774-782
Nondepolarizing muscle relaxants (MRs) display an inverse onset–potency relationship, that is, less potent MRs display a more rapid onset. We have conducted the current investigation to estimate the impact of variable pharmacokinetic or pharmacodyn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51c5faff916b03597dc78e3878a23e0d
https://doi.org/10.1139/y07-072
https://doi.org/10.1139/y07-072
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics. 33:461-483
Nondepolarizing muscle relaxants (MRs) diminish the indirectly evoked single twitch due to their binding to the postsynaptic receptors. Additionally, the MRs produce progressive diminution of successive twitches upon repetitive stimulation (fade). Ou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ee9c5b48e5227f0984352574261ba01
https://doi.org/10.1007/s10928-006-9017-1
https://doi.org/10.1007/s10928-006-9017-1
Autor:
Anton Amann, Vladimir Nigrovic
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics. 29:189-206
Neuromuscular block (NMB) is simulated in pharmacodynamic models using the concentration of a muscle relaxant (MR) in the effect compartment and two constants, γ and IC50. No physiologic or pharmacologic interpretation is offered for either constant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75e0f79fa4de28e4f12a997f6ae19978
https://doi.org/10.1023/a:1019759725394
https://doi.org/10.1023/a:1019759725394
Autor:
Peter Niedermüller, Georg F. Hoffmann, Vladimir Nigrovic, Albert Amberger, Anton Amann, F Pühringer, M Fleischer, Josef Rieder, Christian Marth
Publikováno v:
Anesthesia & Analgesia. 93:690-696
We tested the influence of atracurium and cisatracurium (final concentrations: 0, 0.96, 3.2, 9.6, 32, and 96 microM) on proliferation of human cells (hepatoma HepG2 cells and human umbilical vein endothelial cells) in vitro. In additional experiments
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b24c0420eabf2a4859c709ee0702948
https://doi.org/10.1097/00000539-200109000-00031
https://doi.org/10.1097/00000539-200109000-00031
Autor:
Vladimir Nigrovic, Mark Banoub
Publikováno v:
Clinical Pharmacokinetics. 22:396-408
A pharmacokinetic model was designed to describe simultaneously the plasma concentrations of atracurium and its metabolite laudanosine. The proposed model satisfactorily fits the observations and is based on the assumptions that the parent drug spont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e623279529308e7644637373fa9e090
https://doi.org/10.2165/00003088-199222050-00006
https://doi.org/10.2165/00003088-199222050-00006
Autor:
Vladimir Nigrovic
Publikováno v:
Current Opinion in Anaesthesiology. 4:603-607
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76a47a7abc5d6690785cf47b5ea59427
https://doi.org/10.1097/00001503-199108000-00026
https://doi.org/10.1097/00001503-199108000-00026
Autor:
Vladimir Nigrovic, J. L. Fox
Publikováno v:
Anesthesiology. 74:446-454
Several groups of investigators have reported that the plasma concentrations of laudanosine, a metabolite of atracurium, are high immediately after administration of atracurium and thereafter decline. Such a time profile of a metabolite in plasma is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bbc3d28dbe1082529ae3aaeebc0558c
https://doi.org/10.1097/00000542-199103000-00010
https://doi.org/10.1097/00000542-199103000-00010
Publikováno v:
Journal of pharmacokinetics and pharmacodynamics. 34(6)
The study examined in simulations the interaction between a muscle relaxant and an antagonist that binds the free molecules of the relaxant, as experimentally demonstrated for rocuronium and sugammadex. The hypothetical muscle relaxant D and the hypo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea47f715acdc2e7bb2b637a7ba60dc9
https://pubmed.ncbi.nlm.nih.gov/17882536
https://pubmed.ncbi.nlm.nih.gov/17882536
Publikováno v:
Theoretical Biology and Medical Modelling, Vol 2, Iss 1, p 41 (2005)
Theoretical biology and medical modelling, 2:41
Theoretical Biology & Medical Modelling
Theoretical biology and medical modelling, 2:41
Theoretical Biology & Medical Modelling
Background The study examines the role of the volume of the effect compartment in simulations of neuromuscular block (NMB) produced by nondepolarizing muscle relaxants. Methods The molar amount of the postsynaptic receptors at the motor end plates in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d38829152a977d953471447f0ced1ba8
http://www.tbiomed.com/content/2/1/41
http://www.tbiomed.com/content/2/1/41
Publikováno v:
Musclenerve. 32(6)
To examine the quantitative relationship between indirectly evoked twitch and decreases in the number of either postsynaptic receptors or acetylcholine molecules released by a single stimulus, we studied these variables in a computer-simulated model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51786fa6e10ffd5612637850ccf93ce7
https://pubmed.ncbi.nlm.nih.gov/16094654
https://pubmed.ncbi.nlm.nih.gov/16094654