Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Vladimir N. Podust"'
Autor:
Fiore Cattaruzza, Ayesha Nazeer, Milton To, Mikhail Hammond, Caitlin Koski, Lucas Y. Liu, V. Pete Yeung, Deena A. Rennerfeldt, Angela Henkensiefken, Michael Fox, Sharon Lam, Kari M. Morrissey, Zachary Lange, Vladimir N. Podust, Mika K. Derynck, Bryan A. Irving, Volker Schellenberger
Publikováno v:
Nature Cancer. 4:485-501
To enhance the therapeutic index of T-cell engagers (TCEs), we engineered masked, precision-activated TCEs (XPAT proteins), targeting a tumor antigen (human epidermal growth factor receptor 2 (HER2) or epidermal growth factor receptor (EGFR)) and CD3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d08fc750f9f56209e1642cb13b83c12b
https://doi.org/10.1038/s43018-023-00536-9
https://doi.org/10.1038/s43018-023-00536-9
Autor:
Neelie Zacharias, Vladimir N. Podust, Kimberly K. Kajihara, Douglas Leipold, Geoffrey Del Rosario, Desiree Thayer, Emily Dong, Maciej Paluch, David Fischer, Kai Zheng, Corinna Lei, Jintang He, Carl Ng, Dian Su, Luna Liu, Shabkhaiz Masih, William Sawyer, Jeff Tinianow, Jan Marik, Victor Yip, Guangmin Li, Josefa Chuh, J. Hiroshi Morisaki, Summer Park, Bing Zheng, Hilda Hernandez-Barry, Kelly M. Loyet, Min Xu, Katherine R. Kozak, Gail Lewis Phillips, Ben-Quan Shen, Cong Wu, Keyang Xu, Shang-Fan Yu, Amrita Kamath, Rebecca K. Rowntree, Dorothea Reilly, Thomas Pillow, Andrew Polson, Volker Schellenberger, Wouter L. W. Hazenbos, Jack Sadowsky
Publikováno v:
Chemical Science. 13:3147-3160
The antibody-drug conjugate (ADC) is a well-validated modality for the cell-specific delivery of small molecules with impact expanding rapidly beyond their originally-intended purpose of treating cancer. However, antibody-mediated delivery (AMD) rema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01bce602efd8f14a1021c22dad6d1512
https://doi.org/10.1039/d1sc05243h
https://doi.org/10.1039/d1sc05243h
Autor:
Volker Schellenberger, David Fischer, Bing Zheng, Thomas H. Pillow, Amrita V. Kamath, Carl Ng, Jan Marik, Corinna Lei, Dorothea Reilly, Shabkhaiz Masih, Kelly M. Loyet, Vladimir N. Podust, Kimberly Kajihara, Maciej Paluch, Andrew Polson, Gail Dianne Phillips, Summer Park, Luna Liu, Morisaki John Hiroshi, Kai Zheng, Guangmin Li, Dian Su, Douglas D. Leipold, Josefa Chuh, Victor Yip, Emily Dong, Shang-Fan Yu, Wouter L. W. Hazenbos, Jack Sadowsky, Geoffrey Del Rosario, Rebecca K. Rowntree, Jeff N. Tinianow, Neelie Zacharias, Min Xu, William S. Sawyer, Katherine R. Kozak, Hilda Hernandez-Barry, Jintang He, Cong Wu, Keyang Xu, Ben-Quan Shen
Antibody-drug conjugates (ADCs) enable cell-specific delivery of small molecules and are validated anti-cancer therapeutics. One factor limiting ADC advancement and broader application is the drug-to-antibody ratio (DAR), which dictates the number of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7d05e7d54cc2ba403b546592bdee064
https://doi.org/10.21203/rs.3.rs-356231/v1
https://doi.org/10.21203/rs.3.rs-356231/v1
Autor:
Cynthia Santamaria, Mark W. Duncan, Terry W. Spithill, Momar Ndao, Vladimir N. Podust, Alberto Aché, Regis Perichon, Rebecca Caffrey, Hongshan Li, Brian J. Ward, Malcolm R. Powell
Publikováno v:
Journal of Clinical Microbiology
More than 10 million people are thought to be infected withTrypanosoma cruzi, primarily in the Americas. The clinical manifestations of Chagas' disease (CD) are variable, but most subjects remain asymptomatic for decades. Only 15 to 30% eventually de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b90d7a31c4c786f388aeb3c95c831cee
Autor:
Flavia Cassiola, Tai-Tung Yip, David Cervi, Elise Bender, Vladimir N. Podust, Lena Kikuchi, Giannoula Klement, Nava Almog, Joseph E. Italiano, Mark W. Kieran, Abdo Abou-Slaybi, Judah Folkman, Erin Wheatley
Publikováno v:
Blood. 113:2835-2842
Clinical trials with antiangiogenic agents have not been able to validate plasma or serum levels of angiogenesis regulators as reliable markers of cancer presence or therapeutic response. We recently reported that platelets contain numerous proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::718ffa482daa1b3dd1ae46e023e8dbb0
https://doi.org/10.1182/blood-2008-06-159541
https://doi.org/10.1182/blood-2008-06-159541
Autor:
Vladimir N. Podust, Gunhild Waldemar, Anja Hviid Simonsen, Huw Alun Davies, Niels Andreasen, Ingmar Skoog, Anders Wallin, James Mcguire, Kaj Blennow, Lennart Minthon
Publikováno v:
Neurobiology of Aging. 29:961-968
An early and accurate diagnosis of Alzheimer's disease (AD) is required to initiate symptomatic treatment with currently approved drugs and will be of even greater importance if disease modifying compounds in development display a clinical effect. Pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4d8e41615cd83d006d584627acc1625
https://doi.org/10.1016/j.neurobiolaging.2007.01.011
https://doi.org/10.1016/j.neurobiolaging.2007.01.011
Autor:
Joseph E. Italiano, Judah Folkman, Tai-Tung Yip, Abdo Abou-Slaybi, Nandita Bhattacharya, Nava Almog, George N. Naumov, Elise Bender, Jon E. Peterson, Vladimir N. Podust, Giannoula Klement, David Cervi
Publikováno v:
Blood. 111:1201-1207
Early tumor detection and intervention are important determinants of survival in patients with cancer. We have recently reported that the “platelet angiogenesis proteome” may be used to detect microscopic tumors in mice. We now present evidence t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46ab202ef5f5155099b4fd298106a387
https://doi.org/10.1182/blood-2007-04-084798
https://doi.org/10.1182/blood-2007-04-084798
Autor:
Sara Haghighi, Susann Li, Niklas Mattsson, Ulla Rüetschi, Henrik Zetterberg, Kaj Blennow, Vladimir N. Podust, Oluf Andersen, Mats Stridsberg
Publikováno v:
Journal of Neurochemistry. 103:1932-1939
Novel biomarkers for multiple sclerosis (MS) could improve diagnosis and provide clues to pathogenesis. In this study surface-enhanced laser desorption/ionization time-of-flight mass spectrometry was used to analyze protein expression in CSF from 46
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5251414caec5047941ee8e03fcb59e2e
https://doi.org/10.1111/j.1471-4159.2007.04985.x
https://doi.org/10.1111/j.1471-4159.2007.04985.x
Autor:
Vladimir N. Podust, Aleksandra Gentry-Maharaj, Ian Jacobs, Jeremy Ford, Davy T'Jampens, Elif Arslan-Low, Usha Menon, Zhiyuan Luo, Alexander Gammerman, Eric T. Fung, John F. Timms
Publikováno v:
Clinical Chemistry. 53:645-656
Background: High-throughput proteomic methods for disease biomarker discovery in human serum are promising, but concerns exist regarding reproducibility of results and variability introduced by sample handling. This study investigated the influence o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eea39be1a3c3d65130efc64ee269a70
https://doi.org/10.1373/clinchem.2006.080101
https://doi.org/10.1373/clinchem.2006.080101
Autor:
Christine Yip, Roger K.C. Ngan, Tai Tung Yip, Victor F. Yip, Stephen C.K. Law, Victor W.S. Ma, William C. Cho, Timothy T.C. Yip, Harry H.Y. Yiu, Vladimir N. Podust, Wai Wai Cheng
Publikováno v:
Clinical Chemistry. 53:241-250
Background: We previously used ProteinChip array profiling analysis to discover a serum biomarker associated with nasopharyngeal carcinoma (NPC). In this study, we used the same method to examine other biomarkers associated with NPC and response to c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4d82a1a8028ed38ba02ca6664956a7f
https://doi.org/10.1373/clinchem.2005.065805
https://doi.org/10.1373/clinchem.2005.065805