Výsledky vyhledávání - "Vladimir N. Kolyadko"

Akademický článek

Aptameric hirudins as selective and reversible EXosite-ACTive site (EXACT) inhibitors

Autor: Haixiang Yu, Shekhar Kumar, James W. Frederiksen, Vladimir N. Kolyadko, George Pitoc, Juliana Layzer, Amy Yan, Rachel Rempel, Samuel Francis, Sriram Krishnaswamy, Bruce A. Sullenger

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)

Abstract Potent and selective inhibition of the structurally homologous proteases of coagulation poses challenges for drug development. Hematophagous organisms frequently accomplish this by fashioning peptide inhibitors combining exosite and active s

Externí odkaz: https://doaj.org/article/7a6f52c557ba4dfcb62c6ee0bf629bf7

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Akademický článek

New Infestin-4 Mutants with Increased Selectivity against Factor XIIa.

Autor: Vladimir N Kolyadko, Sofya V Lushchekina, Tatiana A Vuimo, Stepan S Surov, Ruzanna A Ovsepyan, Vera A Korneeva, Ivan I Vorobiev, Nadezhda A Orlova, Leonid Minakhin, Konstantin Kuznedelov, Konstantin V Severinov, Fazoil I Ataullakhanov, Mikhail A Panteleev

Publikováno v: PLoS ONE, Vol 10, Iss 12, p e0144940 (2015)

Factor XIIa (fXIIa) is a serine protease that triggers the coagulation contact pathway and plays a role in thrombosis. Because it interferes with coagulation testing, the need to inhibit fXIIa exists in many cases. Infestin-4 (Inf4) is a Kazal-type i

Externí odkaz: https://doaj.org/article/a3e33141cf504a309b6f154e7fb7c5c9

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The role of transglutaminases in the regulation of phosphatidylserine-positive platelet formation

Autor: A. A. Abaeva, F. I. Ataullakhanov, Mikhail A. Panteleev, Vladimir N. Kolyadko, Ya. N. Kotova, A. O. Yakimenko

Publikováno v: Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology. 9:229-235

Platelets, specialized blood cells, are the most important members of the hemostatic system. Upon activation they divide into two subpopulations, differing greatly in their properties. Platelets from one of these subpopulations express phosphatidylse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f3c65056e4503623d3e703d834cca311
https://doi.org/10.1134/s1990747815040054

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Molecular mechanisms of thrombosis. Fundamental and applied aspects of the contact activation

Autor: Vera A. Korneeva, Vladimir N. Kolyadko, Mikhail A. Panteleev, F. I. Ataullakhanov

Publikováno v: Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology. 8:279-289

The human hemostatic system stops bleeding when vascular lesions occur. This is one of the most vulnerable physiological systems. Hemostatic disorders, which are encountered in patients with various diseases (i.e., atherosclerosis, trauma, sepsis, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8a6ab6e396513b8db74b4d89738bdf2c
https://doi.org/10.1134/s1990747814040059

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Interactions Outside the Proteinase-binding Loop Contribute Significantly to the Inhibition of Activated Coagulation Factor XII by Its Canonical Inhibitor from Corn

Autor: Vladimir G. Lunin, Mikhail A. Panteleev, Mikhail M. Trubetskov, Vladimir N. Kolyadko, Alena V. Korshunova, Fazoil I. Ataullakhanov, Vera A. Korneeva, Sofya V. Lushchekina, O. V. Sergienko

Publikováno v: The Journal of Biological Chemistry

Background: Canonical inhibitors interact with cognate proteases through a protease-binding loop. Results: Protease-binding loop of corn Hageman factor inhibitor (CHFI) does not inhibit its cognate enzyme-activated coagulation factor XII (FXIIa). Con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::626bdd668c2263fe5dfa15edc35830c2
https://doi.org/10.1074/jbc.m114.553735

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Procoagulant Platelets Form an α-Granule Protein-covered 'Cap' on Their Surface That Promotes Their Attachment to Aggregates

Autor: Yana N. Kotova, Anastasia A. Abaeva, Mikhail A. Panteleev, Alena O. Yakimenko, Marie-Christine Alessi, Alan T. Nurden, Nadezhda A. Podoplelova, Hervé Chambost, Vladimir N. Kolyadko, Sergey I. Obydennyy, Matthias Canault, Fazoil I. Ataullakhanov, Aleksei V. Mazurov

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2013, 288 (41), pp.29621-29632. ⟨10.1074/jbc.M113.474163⟩
Journal of Biological Chemistry 41 (288), 29621-29632. (2013)

International audience; Strongly activated "coated" platelets are characterized by increased phosphatidylserine (PS) surface expression, alpha-granule protein retention, and lack of active integrin alpha(IIb)beta(3). To study how they are incorporate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68bfe81380924fc09e18f91f4601a30d
https://doi.org/10.1074/jbc.m113.474163

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New Infestin-4 Mutants with Increased Selectivity against Factor XIIa

Autor: Konstantin Severinov, Ivan I. Vorobiev, Nadezhda A. Orlova, Vera A. Korneeva, Mikhail A. Panteleev, Tatiana A. Vuimo, Sofya V. Lushchekina, Konstantin Kuznedelov, Stepan S. Surov, Fazoil I. Ataullakhanov, Leonid Minakhin, Vladimir N. Kolyadko, Ruzanna A. Ovsepyan

Publikováno v: BASE-Bielefeld Academic Search Engine
PLoS ONE, Vol 10, Iss 12, p e0144940 (2015)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92886cb2ab299574b86254a6dce2612c
https://doi.org/10.1371/journal.pone.0144940

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