Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Vladimir Kubicek"'
Autor:
Lucia Semelkova, Klara Konecna, Pavla Paterova, Vladimir Kubicek, Jiri Kunes, Lucie Novakova, Jan Marek, Lieve Naesens, Matus Pesko, Katarina Kralova, Martin Dolezal, Jan Zitko
Publikováno v:
Molecules, Vol 20, Iss 5, Pp 8687-8711 (2015)
A series of N-alkyl-3-(alkylamino)pyrazine-2-carboxamides and their N-alkyl-3-chloropyrazine-2-carboxamide precursors were prepared. All compounds were characterized by analytical methods and tested for antimicrobial and antiviral activity. The antim
Externí odkaz:
https://doaj.org/article/3653008a8d034514ae0939014f3aae09
Autor:
Ondrej Jandourek, Martin Dolezal, Jiri Kunes, Vladimir Kubicek, Pavla Paterova, Matus Pesko, Vladimir Buchta, Katarina Kralova, Jan Zitko
Publikováno v:
Molecules, Vol 19, Iss 7, Pp 9318-9338 (2014)
A series of 18 N-alkyl substituted 3-aminopyrazine-2-carboxamides was prepared in this work according to previously experimentally set and proven conditions using microwave assisted synthesis methodology. This approach for the aminodehalogenation rea
Externí odkaz:
https://doaj.org/article/e67a8d04c70a4355bea366772026d6dc
Autor:
Ondrej Jandourek, Martin Dolezal, Pavla Paterova, Vladimir Kubicek, Matus Pesko, Jiri Kunes, Aidan Coffey, Jiahui Guo, Katarina Kralova
Publikováno v:
Molecules, Vol 19, Iss 1, Pp 651-671 (2014)
In this work a series of 15 N-benzylamine substituted 5-amino-6-methyl-pyrazine-2,3-dicarbonitriles was prepared by the aminodehalogenation reactions using microwave assisted synthesis with experimentally set and proven conditions. This approach for
Externí odkaz:
https://doaj.org/article/4dbea44fdabe4fd38e3a262c46e5f149
Autor:
Ondrej Jandourek, Marek Tauchman, Pavla Paterova, Klara Konecna, Lucie Navratilova, Vladimir Kubicek, Ondrej Holas, Jan Zitko, Martin Dolezal
Publikováno v:
Molecules, Vol 22, Iss 2, p 223 (2017)
Aminodehalogenation of 3-chloropyrazine-2-carboxamide with variously substituted benzylamines yielded a series of fifteen 3-benzylaminopyrazine-2-carboxamides. Four compounds possessed in vitro whole cell activity against Mycobacterium tuberculosis H
Externí odkaz:
https://doaj.org/article/64c36c0952024fca9c1b116703ff33fc
Autor:
Petr Šlechta, Ondřej Jand’ourek, Klára Konečná, Pavla Paterová, Pavel Bárta, Vladimír Kubíček, Martin Doležal, Marta Kučerová-Chlupáčová
Publikováno v:
Medical Sciences Forum, Vol 14, Iss 1, p 133 (2022)
The current study is focused on the combination of pyrazinamide with 6-aminobenzo[c][1,2]oxaborol-1(3H)-ol, which is a crucial pharmacophore of several antimicrobial agents. The use of benzoxaborole moiety could afford the formation of a spiro adduct
Externí odkaz:
https://doaj.org/article/e25ce61262bb44ff81190f948987b53c
Autor:
Vladimír Kubíček, Lenka Skálová, Adam Skarka, Věra Králová, Jana Holubová, Jana Štěpánková, Zdeněk Šubrt, Barbora Szotáková
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Flubendazole (FLU), an anthelmintic drug of benzimidazole type, is now considered a promising anti-cancer agent due to its tubulin binding ability and low system toxicity. The present study was aimed at determining more information about FLU reductio
Externí odkaz:
https://doaj.org/article/02afe841c66e4d86826b5a44424b5c57
Autor:
Jakub Wantulok, Daniel Swoboda, Jacek E. Nycz, Maria Książek, Joachim Kusz, Jan Grzegorz Małecki, Vladimír Kubíček
Publikováno v:
Molecules, Vol 26, Iss 7, p 1857 (2021)
The vicarious nucleophilic substitution of hydrogen (VNS) reaction in electron-deficient nitroquinolines was studied. Properties of all new products have been characterized by several techniques: MS, HRMS, FTIR, GC-MS, electronic absorption spectrosc
Externí odkaz:
https://doaj.org/article/64aa08c3e22c4a69b690e16d59787026
Autor:
Martin Juhás, Lucie Kučerová, Ondřej Horáček, Ondřej Janďourek, Vladimír Kubíček, Klára Konečná, Radim Kučera, Pavel Bárta, Jiří Janoušek, Pavla Paterová, Jiří Kuneš, Martin Doležal, Jan Zitko
Publikováno v:
Molecules, Vol 25, Iss 7, p 1518 (2020)
Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis (Mtb), each year causing millions of deaths. In this article, we present the synthesis and biological evaluations of new potential antimycobacterial compounds containing a fra
Externí odkaz:
https://doaj.org/article/3ebe505765e4433694cb85089c82811a
Autor:
Ghada Bouz, Martin Juhás, Lluis Pausas Otero, Cristina Paredes de la Red, Ondřej Janďourek, Klára Konečná, Pavla Paterová, Vladimír Kubíček, Jiří Janoušek, Martin Doležal, Jan Zitko
Publikováno v:
Molecules, Vol 25, Iss 1, p 138 (2019)
We prepared a series of substituted N-(pyrazin-2-yl)benzenesulfonamides as an attempt to investigate the effect of different linkers connecting pyrazine to benzene cores on antimicrobial activity when compared to our previous compounds of amide or re
Externí odkaz:
https://doaj.org/article/4cd83c171006456d912e56b43889f76b
Autor:
Ghada Bouz, Lucia Semelková, Ondřej Janďourek, Klára Konečná, Pavla Paterová, Lucie Navrátilová, Vladimír Kubíček, Jiří Kuneš, Martin Doležal, Jan Zitko
Publikováno v:
Molecules, Vol 24, Iss 7, p 1212 (2019)
We report the design, synthesis, and in vitro antimicrobial activity of a series of N-substituted 3-aminopyrazine-2-carboxamides with free amino groups in position 3 on the pyrazine ring. Based on various substituents on the carboxamidic moiety, the
Externí odkaz:
https://doaj.org/article/25a173b05faf483595484eebf694af80