Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Vladimir Ilyukha"'
Autor:
Hayley I. Muendlein, Wilson M. Connolly, Zoie Magri, Irina Smirnova, Vladimir Ilyukha, Avishekh Gautam, Alexei Degterev, Alexander Poltorak
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Yersiania YopJ protein has been shown to drive caspase-8-mediated pyroptosis. Here the authors show a precise mechanism of this non-canonical cell death pathway that is controlled by a TRIF-dependent complex of FADD, RIPK1, caspase-8 and ZBP1.
Externí odkaz:
https://doaj.org/article/c23eacb750254746b5eeb2cdfdaf0689
Autor:
Marina Anastasiou, Gail A. Newton, Kuljeet Kaur, Francisco J. Carrillo-Salinas, Sasha A. Smolgovsky, Abraham L. Bayer, Vladimir Ilyukha, Shruti Sharma, Alexander Poltorak, Francis W. Luscinskas, Pilar Alcaide
Publikováno v:
JCI Insight, Vol 6, Iss 15 (2021)
The stimulator of IFN genes (STING) protein senses cyclic dinucleotides released in response to double-stranded DNA and functions as an adaptor molecule for type I IFN (IFNI) signaling by activating IFNI-stimulated genes (ISG). We found impaired T ce
Externí odkaz:
https://doaj.org/article/416b3de649144e29a5509b756c42a295
Autor:
Hayley I. Muendlein, Joseph Sarhan, Beiyun C. Liu, Wilson M. Connolly, Stephen A. Schworer, Irina Smirnova, Amy Y. Tang, Vladimir Ilyukha, Jodie Pietruska, Soroush Tahmasebi, Nahum Sonenberg, Alexei Degterev, Alexander Poltorak
Publikováno v:
Cell Reports, Vol 30, Iss 3, Pp 699-713.e4 (2020)
Summary: Receptor-interacting protein kinase 1 (RIPK1) and 3 (RIPK3) are well known for their capacity to drive necroptosis via mixed-lineage kinase-like domain (MLKL). Recently, RIPK1/3 kinase activity has been shown to drive inflammation via activa
Externí odkaz:
https://doaj.org/article/b14db846e8cc4f8c8f65d98ff6c63481
Publikováno v:
Transactions of the Karelian Research Centre of the Russian Academy of Sciences, Iss 11, Pp 88-97 (2016)
The activity and localization of enzymes in blood leukocytes were examined in dark brown (+/+), silver-blue (p/p) and sapphire (a/a p/p) minks during several periods of postnatal development. This study was performed by morphometric and cytochemical
Externí odkaz:
https://doaj.org/article/4179e3cb13d6416a910265ef229f1b28
Autor:
Beiyun C. Liu, Joseph Sarhan, Alexander Panda, Hayley I. Muendlein, Vladimir Ilyukha, Jörn Coers, Masahiro Yamamoto, Ralph R. Isberg, Alexander Poltorak
Publikováno v:
Cell Reports, Vol 24, Iss 1, Pp 155-168.e5 (2018)
Summary: Legionella pneumophila elicits caspase-11-driven macrophage pyroptosis through guanylate-binding proteins (GBPs) encoded on chromosome 3. It has been proposed that microbe-driven IFN upregulates GBPs to facilitate pathogen vacuole rupture an
Externí odkaz:
https://doaj.org/article/217eebaf70ed4ee88874c232373dfad4
Autor:
Vladimir Ilyukha, Alexei Degterev, Wilson M. Connolly, Hayley I. Muendlein, Beiyun C. Liu, Nahum Sonenberg, Jodie R. Pietruska, Alexander Poltorak, Stephen A Schworer, Amy Y. Tang, Irina Smirnova, Joseph Sarhan, Soroush Tahmasebi
Publikováno v:
Cell Reports, Vol 30, Iss 3, Pp 699-713.e4 (2020)
Cell reports
Cell reports
SUMMARY Receptor-interacting protein kinase 1 (RIPK1) and 3 (RIPK3) are well known for their capacity to drive necroptosis via mixed-lineage kinase-like domain (MLKL). Recently, RIPK1/3 kinase activity has been shown to drive inflammation via activat
Autor:
Alexander Poltorak, Francis W. Luscinskas, Francisco J. Carrillo-Salinas, Marina Anastasiou, Kuljeet Kaur, Gail Newton, Sasha Smolgovsky, Vladimir Ilyukha, Abraham L Bayer, Shruti Sharma, Pilar Alcaide
Publikováno v:
JCI Insight
The stimulator of interferon genes (STING) protein senses cyclic di-nucleotides released in response to double stranded DNA, and functions as an adaptor molecule for type I interferon (IFN-I) signaling by activating IFN-I stimulated genes (ISG). We f
Autor:
Vladimir Ilyukha, Avishekh Gautam, Alexei Degterev, Wilson M. Connolly, Zoie Magri, Alexander Poltorak, Irina Smirnova, Hayley I. Muendlein
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
Inflammation and cell death are closely linked arms of the host immune response to infection, which when carefully balanced ensure host survival. One example of this balance is the tightly regulated transition from TNFR1-associated pro-inflammatory c
Publikováno v:
Transactions of the Karelian Research Centre of the Russian Academy of Sciences, Iss 11, Pp 88-97 (2016)
The activity and localization of enzymes in blood leukocytes were examined in dark brown (+/+), silver-blue (p/p) and sapphire (a/a p/p) minks during several periods of postnatal development. This study was performed by morphometric and cytochemical
Publikováno v:
Journal of Biomedical Technologies. :53-55