Zobrazeno 1 - 10
of 158
pro vyhledávání: '"Vladimir I. Polshakov"'
Autor:
Alexander Yu Rudenko, Sofia S. Mariasina, Anastasiia K. Bolikhova, Maxim V. Nikulin, Ratislav M. Ozhiganov, Vasiliy G. Vasil’ev, Yuri A. Ikhalaynen, Anastasia L. Khandazhinskaya, Maxim A. Khomutov, Peter V. Sergiev, Alex R. Khomutov, Vladimir I. Polshakov
Publikováno v:
Frontiers in Chemistry, Vol 12 (2024)
S-Adenosyl-l-methionine (SAM)-mediated methylation of biomolecules controls their function and regulates numerous vital intracellular processes. Analogs of SAM with a reporter group in place of the S-methyl group are widely used to study these proces
Externí odkaz:
https://doaj.org/article/77e58f40aa35434d87abbb35bd6ea9be
Autor:
Igor B. Levshin, Alexander Yu. Simonov, Alexey A. Panov, Natalia E. Grammatikova, Alexander I. Alexandrov, Eslam S. M. O. Ghazy, Vasiliy A. Ivlev, Michael O. Agaphonov, Alexey B. Mantsyzov, Vladimir I. Polshakov
Publikováno v:
Pharmaceuticals, Vol 17, Iss 6, p 723 (2024)
A series of hybrid compounds with triazole and thiazolidine nuclei connected by a linker has been synthesized and extensively studied. Various synthetic methods for the target compounds have been tested. A microbiological assessment of the obtained c
Externí odkaz:
https://doaj.org/article/13483073eed24242ad00227215e7d07b
Autor:
Sofia S. Mariasina, Chi-Fon Chang, Tsimafei L. Navalayeu, Anastasia A. Chugunova, Sergey V. Efimov, Viktor G. Zgoda, Vasily A. Ivlev, Olga A. Dontsova, Petr V. Sergiev, Vladimir I. Polshakov
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Williams-Beuren syndrome (WBS) is a genetic disorder associated with the hemizygous deletion of several genes in chromosome 7, encoding 26 proteins. Malfunction of these proteins induce multisystemic failure in an organism. While biological functions
Externí odkaz:
https://doaj.org/article/fa4894815edf4cd6ba425ccf5c8d7f8e
Autor:
Nikita M. Shepelev, Sofia S. Mariasina, Alexey B. Mantsyzov, Alexander N. Malyavko, Sergey V. Efimov, Olga A. Petrova, Elena V. Rodina, Maria I. Zvereva, Olga A. Dontsova, Vladimir I. Polshakov
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Abstract Telomerase is a ribonucleoprotein enzyme, which maintains genome integrity in eukaryotes and ensures continuous cellular proliferation. Telomerase holoenzyme from the thermotolerant yeast Hansenula polymorpha, in addition to the catalytic su
Externí odkaz:
https://doaj.org/article/c30a64ef786b423ca96996243d680aa3
Publikováno v:
eLife, Vol 11 (2022)
Rif1 is a large multifaceted protein involved in various processes of DNA metabolism – from telomere length regulation and replication to double-strand break repair. The mechanistic details of its action, however, are often poorly understood. Here,
Externí odkaz:
https://doaj.org/article/3450b54fe3ec4ecab4f33ed5f3e5ee04
Autor:
Julia A. Pavlova, Andrey G. Tereshchenkov, Pavel A. Nazarov, Dmitrii A. Lukianov, Dmitry A. Skvortsov, Vladimir I. Polshakov, Byasilya F. Vasilieva, Olga V. Efremenkova, Mikhail Y. Kaiumov, Alena Paleskava, Andrey L. Konevega, Olga A. Dontsova, Ilya A. Osterman, Alexey A. Bogdanov, Natalia V. Sumbatyan
Publikováno v:
Antibiotics, Vol 12, Iss 1, p 15 (2022)
In order to obtain antimicrobial compounds with improved properties, new conjugates comprising two different biologically active agents within a single chimeric molecule based on chloramphenicol (CHL) and a hydrophobic cation were synthesized and stu
Externí odkaz:
https://doaj.org/article/a605ba928b33422cadcd2b7d2d8bc6a5
Autor:
Vera A. Alferova, Tinashe P. Maviza, Mikhail V. Biryukov, Yuliya V. Zakalyukina, Vladimir I. Polshakov, Petr V. Sergiev, Vladimir A. Korshun, Ilya A. Osterman
Publikováno v:
Biochimie. 206:150-153
The aromatic polyketides tetracenomycins were recently found to be potent inhibitors of protein synthesis. Their binding site is located in a unique locus within the tunnel of the large ribosomal subunit. Here we report the isolation and structure el
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25b6af4e97125e359d04b3ee71875a92
https://doi.org/10.1016/j.biochi.2022.10.016
https://doi.org/10.1016/j.biochi.2022.10.016
Autor:
Igor B. Levshin, Alexander Y. Simonov, Sergey N. Lavrenov, Alexey A. Panov, Natalia E. Grammatikova, Alexander A. Alexandrov, Eslam S. M. O. Ghazy, Nikita A. Savin, Peter V. Gorelkin, Alexander S. Erofeev, Vladimir I. Polshakov
Publikováno v:
Pharmaceuticals, Vol 15, Iss 5, p 563 (2022)
Novel derivatives of Mycosidine (3,5-substituted thiazolidine-2,4-diones) are synthesized by Knoevenagel condensation and reactions of thiazolidines with chloroformates or halo-acetic acid esters. Furthermore, 5-Arylidene-2,4-thiazolidinediones and t
Externí odkaz:
https://doaj.org/article/2f7f303cc2264d6282e8aece6f627613
Autor:
Stanislav A. Petrov, Aleksei E. Machulkin, Anastasia A. Uspenskaya, Nikolay Y. Zyk, Ekaterina A. Nimenko, Anastasia S. Garanina, Rostislav A. Petrov, Vladimir I. Polshakov, Yuri K. Grishin, Vitaly A. Roznyatovsky, Nikolay V. Zyk, Alexander G. Majouga, Elena K. Beloglazkina
Publikováno v:
Molecules, Vol 25, Iss 24, p 5784 (2020)
A strategy for stereoselective synthesis of molecular platform for targeted delivery of bimodal therapeutic or theranostic agents to the prostate-specific membrane antigen (PSMA) receptor was developed. The proposed platform contains a urea-based, PS
Externí odkaz:
https://doaj.org/article/ae00a4fa5629496f8c958afc95c1484f
Autor:
Anzhela V. Pavlova, Mayya V. Monakhova, Anna M. Ogloblina, Natalia A. Andreeva, Gennady Yu. Laptev, Vladimir I. Polshakov, Elizaveta S. Gromova, Maria I. Zvereva, Marianna G. Yakubovskaya, Tatiana S. Oretskaya, Elena A. Kubareva, Nina G. Dolinnaya
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 22, p 8773 (2020)
DNA mismatch repair (MMR) plays a crucial role in the maintenance of genomic stability. The main MMR protein, MutS, was recently shown to recognize the G-quadruplex (G4) DNA structures, which, along with regulatory functions, have a negative impact o
Externí odkaz:
https://doaj.org/article/0fc4c203ba9641169340eb92738c5065