Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Vladimir I. Gelfand"'
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103536- (2022)
Summary: Ataxin-2 (Atx2) is a highly conserved RNA binding protein. Atx2 undergoes polyglutamine expansion leading to amyotrophic lateral sclerosis (ALS) or spinocerebellar ataxia type 2 (SCA2). However, the physiological functions of Atx2 in neurons
Externí odkaz:
https://doaj.org/article/4904c8d45acb41bbbcc86d151a6d0f4f
Autor:
Martin F. Engelke, Michael Winding, Yang Yue, Shankar Shastry, Federico Teloni, Sanjay Reddy, T. Lynne Blasius, Pushpanjali Soppina, William O. Hancock, Vladimir I. Gelfand, Kristen J. Verhey
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
The use of specific small molecule inhibitors can contribute to the study of kinesins' cellular functions. Here the authors develop a chemical-genetic approach to engineer kinesin motors that can be efficiently inhibited upon addition of cell-permeab
Externí odkaz:
https://doaj.org/article/d400141931f143c5987411f968b209bc
Autor:
Amber L. Jolly, Chi-Hao Luan, Brendon E. Dusel, Sara F. Dunne, Michael Winding, Vishrut J. Dixit, Chloe Robins, Jennifer L. Saluk, David J. Logan, Anne E. Carpenter, Manu Sharma, Deborah Dean, Andrew R. Cohen, Vladimir I. Gelfand
Publikováno v:
Cell Reports, Vol 14, Iss 3, Pp 611-620 (2016)
Long-distance intracellular transport of organelles, mRNA, and proteins (“cargo”) occurs along the microtubule cytoskeleton by the action of kinesin and dynein motor proteins, but the vast network of factors involved in regulating intracellular c
Externí odkaz:
https://doaj.org/article/4523938e4c874274bcf79c99754ac9b9
Autor:
Amber L. Jolly, Vladimir I. Gelfand
Publikováno v:
Communicative & Integrative Biology, Vol 3, Iss 6, Pp 589-591 (2010)
There are well known examples in nature of microtubules dramatically changing their function by re-organizing their structure. Most interphase animal cells rely on the radial organization of the microtubule network for precise cargo delivery. Dividin
Externí odkaz:
https://doaj.org/article/54c2db08258b4f25bac7ed969c3bd738
Publikováno v:
eLife, Vol 11 (2022)
Cytoplasmic dynein, a major minus-end directed microtubule motor, plays essential roles in eukaryotic cells. Drosophila oocyte growth is mainly dependent on the contribution of cytoplasmic contents from the interconnected sister cells, nurse cells. W
Externí odkaz:
https://doaj.org/article/627f6008193a4700abce28ef6365cd0d
Autor:
Wen Lu, Margot Lakonishok, Rong Liu, Neil Billington, Ashley Rich, Michael Glotzer, James R Sellers, Vladimir I Gelfand
Publikováno v:
eLife, Vol 9 (2020)
Local accumulation of oskar (osk) mRNA in the Drosophila oocyte determines the posterior pole of the future embryo. Two major cytoskeletal components, microtubules and actin filaments, together with a microtubule motor, kinesin-1, and an actin motor,
Externí odkaz:
https://doaj.org/article/da1f41b7385848a7b9f2c71e6841a8dd
Publikováno v:
eLife, Vol 9 (2020)
Correct neuronal development requires tailored neurite outgrowth. Neurite outgrowth is driven in part by microtubule-sliding – the transport of microtubules along each other. We have recently demonstrated that a ‘mitotic’ kinesin-6 (Pavarotti i
Externí odkaz:
https://doaj.org/article/72ba507245d2416d8cb0bdf80baf3750
Autor:
Bhuvanasundar Renganathan, James P. Zewe, Yuan Cheng, Jean‐Michel Paumier, Mark Kittisopikul, Karen M. Ridge, Puneet Opal, Vladimir I. Gelfand
Publikováno v:
The FASEB Journal. 37
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67c291e6784070af7ab99fc9309fe8c4
https://doi.org/10.1096/fsb2.22956
https://doi.org/10.1096/fsb2.22956
Autor:
Sayantan Dutta, Reza Farhadifar, Wen Lu, Gokberk Kabacaoğlu, Robert Blackwell, David B. Stein, Margot Lakonishok, Vladimir I. Gelfand, Stanislav Y. Shvartsman, Michael J. Shelley
Life in complex systems, such as cities and organisms, comes to a standstill when global coordination of mass, energy, and information flows is disrupted. Global coordination is no less important in single cells, especially in large oocytes and newly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a57141f5707f5b5bdbce0a12457ec9f5
https://doi.org/10.1101/2023.04.04.534476
https://doi.org/10.1101/2023.04.04.534476
In many species, only one oocyte is specified among a group of interconnected germline sister cells. InDrosophila melanogaster, 16-cell interconnected cells form a germline cyst, where one cell differentiates into an oocyte, while the rest become nur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a02678ab3897d859eacedb20518a7bed
https://doi.org/10.1101/2023.03.09.531953
https://doi.org/10.1101/2023.03.09.531953