Výsledky vyhledávání - "Vladimir Geneus"

P193 Clinical features of patients with active ankylosing spondylitis who did not respond to adalimumab but responded to ixekizumab: a post-hoc analysis

Autor: David Marcelino Sandoval Calderon, Vladimir Geneus, Xenofon Baraliakos, David H. Adams, Rebecca Bolce, Atul Deodhar, Joachim Sieper, Jessica A. Walsh, Soyi Liu Leage

Publikováno v: Rheumatology. 60

Background/Aims Biologic treatment in ankylosing spondylitis (AS) are currently limited to TNF and IL-17A inhibitors (IL-17Ai). It is unknown whether there are predictors of AS patients who only respond to 1 of these mechanisms of action or respond t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bf42d4378e40119caba74dbe5b92e4ad
https://doi.org/10.1093/rheumatology/keab247.188

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Efficacy and Safety of Ixekizumab in Patients with Psoriatic Arthritis and Inadequate Response to TNF Inhibitors: 3-Year Follow-Up (SPIRIT-P2)

Autor: Lisa Macpherson, Stephen Hall, Anthony M. Turkiewicz, Julie Birt, Amanda M. Gellett, Jordi Gratacós, Eva Dokoupilova, Bernard Combe, Arnaud Constantin, Gaia Gallo, Peter Nash, Aubrey Trevelin Sprabery, Clinton C. Bertram, Vladimir Geneus, Ana Maria Orbai

Publikováno v: Rheumatology and Therapy
Rheumatology and Therapy, Springer, 2021, 8 (1), pp.199-217. ⟨10.1007/s40744-020-00261-0⟩

Purpose Ixekizumab is a high-affinity monoclonal antibody that selectively targets interleukin-17A. The objective of this study was to assess the long-term efficacy and safety (to week 156) of ixekizumab in patients with active psoriatic arthritis an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::456110759ab4cc3dc27075d6aed08f71
https://hal.umontpellier.fr/hal-03222570/document

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AB0814 SUSTAINED IMPROVEMENTS IN PHYSICAL FUNCTION, QUALITY OF LIFE, AND WORK PRODUCTIVITY WITH IXEKIZUMAB IN PATIENTS WITH ACTIVE PSORIATIC ARTHRITIS AND PREVIOUS INADEQUATE RESPONSE TO TUMOUR NECROSIS FACTOR-INHIBITORS: 3-YEAR RESULTS FROM SPIRIT-P2 TRIAL

Autor: Amanda M. Gellett, Vladimir Geneus, B. Combe, Aubrey Trevelin Sprabery, Eva Dokoupilova, J. Gratacos-Masmitja, Arnaud Constantin, A. M. Orbai, P. Nash, Julie Birt

Publikováno v: Annals of the Rheumatic Diseases. 79:1709-1710

Background:Ixekizumab (IXE), a high-affinity monoclonal antibody that selectively targets IL-17A, has shown improvements compared to placebo (PBO) not only in disease activity but also in various patient-reported outcomes (PROs) assessing physical fu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b7bdff50ddae59ba41a4b57de1d89812
https://doi.org/10.1136/annrheumdis-2020-eular.2087

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AB0744 EFFICACY OF IXEKIZUMAB IN ACTIVE PSORIATIC ARTHRITIS (PSA) PATIENTS WITH AXIAL PAIN STARTING BEFORE AGE 45: A SUBGROUP ANALYSIS OF SPIRIT-P1 AND SPIRIT-P2 PHASE 3 CLINICAL TRIALS

Autor: Alexis Ogdie, Talia M. Muram, Atul Deodhar, Vladimir Geneus, D. Sandoval, Peter Nash

Publikováno v: Abstracts accepted for Publication.

Background The efficacy and safety of ixekizumab (IXE), an IL-17A antagonist, was investigated in patients with active psoriatic arthritis (PsA) in the SPIRIT-P1 and SPIRIT-P2 clinical trials. Objectives To investigate the efficacy of ixekizumab on a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::90e5cc46f0fb725e9c42bc6029022e39
https://doi.org/10.1136/annrheumdis-2019-eular.1235

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FRI0398 IXEKIZUMAB IS EFFECTIVE IN THE TREATMENT OF RADIOGRAPHIC AXIAL SPONDYLOARTHRITIS REGARDLESS OF THE LEVEL OF C-REACTIVE PROTEIN OR MAGNETIC RESONANCE IMAGING SCORES: 16-WEEK DATA FROM COAST-V AND COAST-W

Autor: Mikkel Ǿstergaard, Lianne S. Gensler, Fangyi Zhao, Kurisu Tada, Rebecca Bolce, Gaia Gallo, Walter P. Maksymowych, Atul Deodhar, Vladimir Geneus

Publikováno v: Spondyloarthritis – treatment.

Background Radiographic axial spondyloarthritis (r-axSpA) is a chronic inflammatory disease of the axial skeleton, and interleukin (IL)-17 plays an important role in the pathogenesis. Elevated C-reactive protein (CRP) levels in serum predict response

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b6a179ccc63af7c9ad3c9360fc68840e
https://doi.org/10.1136/annrheumdis-2019-eular.1466

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POS0228 BASELINE CHARACTERISTICS AND TREATMENT RESPONSE TO IXEKIZUMAB CATEGORISED BY SEX IN RADIOGRAPHIC AND NON-RADIOGRAPHIC AXIAL SPONDYLARTHRITIS PATIENTS THROUGH 52 WEEKS: DATA FROM 3 PHASE III, RANDOMIZED, CONTROLLED TRIALS

Autor: D. Sandoval, Marina Magrey, Jeffrey R. Lisse, Vladimir Geneus, D. Zhu, S. Liu Leage, I E van der Horst-Bruinsma, Theresa Hunter, Rebecca Bolce

Publikováno v: Annals of the Rheumatic Diseases. 80:333.2-334

Background:Axial spondyloarthritis (axSpA) is a chronic inflammatory disease of the axial skeleton comprising two subtypes within the same spectrum: radiographic (r-axSpA) and non-radiographic (nr-axSpA). Previous studies have shown that clinical pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::75d79d61df54c6d834873371d05a685d
https://doi.org/10.1136/annrheumdis-2021-eular.684

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SAT0411 EFFICACY AND SAFETY OF IXEKIZUMAB IN PATIENTS WITH PSORIATIC ARTHRITIS AND INADEQUATE RESPONSE TO TNF INHIBITORS: THREE YEAR RESULTS FROM A PHASE 3 STUDY (SPIRIT-P2)

Autor: Amanda M. Gellett, Vladimir Geneus, Anthony Turkiewicz, J. Gratacos-Masmitja, Arnaud Constantin, Eva Dokoupilova, Aubrey Trevelin Sprabery

Publikováno v: Annals of the Rheumatic Diseases. 79:1158.1-1158

Background:Ixekizumab (IXE) is a high affinity monoclonal antibody that selectively targets interleukin-17A. In the SPIRIT-P2 study, IXE every 4 (Q4W) or 2 (Q2W) weeks was superior to placebo (PBO) in improving the signs and symptoms of psoriatic art

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ed9864d182f807a95b48c675b9a48819
https://doi.org/10.1136/annrheumdis-2020-eular.1482

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