Author Correction: The cardiac molecular setting of metabolic syndrome in pigs reveals disease susceptibility and suggests mechanisms that exacerbate COVID-19 outcomes in patients

Autor: Olivia Ziegler, Nivedita Sriram, Vladimir Gelev, Denitsa Radeva, Kostadin Todorov, Jun Feng, Frank W. Sellke, Simon C. Robson, Makoto Hiromura, Boian S. Alexandrov, Anny Usheva

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-1 (2021)

Externí odkaz: https://doaj.org/article/3c4c33c8d83e44f096b11e95ee1569a2

DNA dynamics is likely to be a factor in the genomic nucleotide repeats expansions related to diseases.

Autor: Boian S Alexandrov, Vlad I Valtchinov, Ludmil B Alexandrov, Vladimir Gelev, Yossi Dagon, Jonathan Bock, Isaac S Kohane, Kim Ø Rasmussen, Alan R Bishop, Anny Usheva

Publikováno v: PLoS ONE, Vol 6, Iss 5, p e19800 (2011)

Trinucleotide repeats sequences (TRS) represent a common type of genomic DNA motif whose expansion is associated with a large number of human diseases. The driving molecular mechanisms of the TRS ongoing dynamic expansion across generations and withi

Externí odkaz: https://doaj.org/article/4fcc499d21a740f198e930fffdda7eb6

Lokale Deuterierung ermöglicht NMR‐Messung von Methylgruppen in Proteinen aus eukaryotischen und Zell‐freien Expressionssystemen

Autor: Ognyan Petrov, Sandeep Chhabra, Nikola Burdzhiev, Abhinav Dubey, Eric S. Fischer, Jan Borggräfe, Aldino Viegas, Shantha Elter, Radosław P. Nowak, Haribabu Arthanari, Thibault Viennet, Vladimir Gelev, Nikolay Stoyanov, Manuel Etzkorn

Publikováno v: Angewandte Chemie. 133:13902-13906

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ca849cc71d260f441c1ff56bf11aeac6
https://doi.org/10.1002/ange.202016070

The cardiac molecular setting of metabolic syndrome in pigs reveals disease susceptibility and suggests mechanisms that exacerbate COVID-19 outcomes in patients

Autor: Kostadin Todorov, Denitsa Radeva, Nivedita Sriram, Simon C. Robson, Jun Feng, Olivia Ziegler, Boian S. Alexandrov, Anny Usheva, Frank W. Sellke, Vladimir Gelev, Makoto Hiromura

Publikováno v: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)

Although metabolic syndrome (MetS) is linked to an elevated risk of cardiovascular disease (CVD), the cardiac-specific risk mechanism is unknown. Obesity, hypertension, and diabetes (all MetS components) are the most common form of CVD and represent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19c59d012da7fb0436872e52ae6b7f0b
https://pubmed.ncbi.nlm.nih.gov/34711865

Local Deuteration Enables NMR Observation of Methyl Groups in Proteins from Eukaryotic and Cell-Free Expression Systems

Autor: Nikolay Stoyanov, Sandeep Chhabra, Abhinav Dubey, Thibault Viennet, Eric S. Fischer, Radosław P. Nowak, Nikola Burdzhiev, Vladimir Gelev, Jan Borggräfe, Shantha Elter, Manuel Etzkorn, Ognyan Petrov, Aldino Viegas, Haribabu Arthanari

Publikováno v: Angewandte Chemie (International Ed. in English)
Angewandte Chemie / International edition 60(25), 13783-13787 (2021). doi:10.1002/anie.202016070

Therapeutically relevant proteins such as GPCRs, antibodies and kinases face clear limitations in NMR studies due to the challenges in site‐specific isotope labeling and deuteration in eukaryotic expression systems. Here we describe an efficient an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed875eec167c5db9f4d5da49b85a61a2
https://pubmed.ncbi.nlm.nih.gov/33768661