Cannabidiol Modifies the Glutamate Over-Release in Brain Tissue of Patients and Rats with Epilepsy: A Pilot Study

Autor: Christopher Martínez-Aguirre, Luis Alfredo Márquez, Cindy Lizbeth Santiago-Castañeda, Francia Carmona-Cruz, Maria de los Angeles Nuñez-Lumbreras, Vladimir A. Martínez-Rojas, Mario Alonso-Vanegas, Gustavo Aguado-Carrillo, Norma L. Gómez-Víquez, Emilio J. Galván, Manola Cuéllar-Herrera, Luisa Rocha

Publikováno v: Biomedicines, Vol 11, Iss 12, p 3237 (2023)

Drug-resistant epilepsy (DRE) is associated with high extracellular levels of glutamate. Studies support the idea that cannabidiol (CBD) decreases glutamate over-release. This study focused on investigating whether CBD reduces the evoked glutamate re

Externí odkaz: https://doaj.org/article/12024f5f538b42389d970f7b61fbc876

GABAB Receptors Tonically Inhibit Motoneurons and Neurotransmitter Release from Descending and Primary Afferent Fibers

Autor: Ximena Delgado-Ramírez, Nara S. Alvarado-Cervantes, Natalie Jiménez-Barrios, Guadalupe Raya-Tafolla, Ricardo Felix, Vladimir A. Martínez-Rojas, Rodolfo Delgado-Lezama

Publikováno v: Life, Vol 13, Iss 8, p 1776 (2023)

Motoneurons receive thousands of excitatory and inhibitory synapses from descending tracts and primary afferent fibers. The excitability of these neurons must be precisely regulated to respond adequately to the requirements of the environment. In thi

Externí odkaz: https://doaj.org/article/e6d6d7d410164d0186d05063144f94f3

Interaction of NHE1 and TRPA1 Activity in DRG Neurons Isolated from Adult Rats and its Role in Inflammatory Nociception

Autor: Norma L. Gómez-Viquez, Francisco Mercado, Vinicio Granados-Soto, Janet Murbartián, Vladimir A. Martínez-Rojas, Ana Belen Salinas-Abarca

Publikováno v: Neuroscience. 465:154-165

Transient receptor potential ankyrin 1 (TRPA1) channel is expressed in a subset of nociceptive neurons. This channel integrates several nociceptive signals. Particularly, it is modulated by intracellular pH (pHi). Na+/H+ exchanger 1 (NHE1) contribute

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f5a9ecc2cb5892e59c3415e9ee2476e
https://doi.org/10.1016/j.neuroscience.2021.04.025

A Monolayer System for the Efficient Generation of Motor Neuron Progenitors and Functional Motor Neurons from Human Pluripotent Stem Cells

Autor: Daniele Arosio, Ingrid Battistella, Daniela Rossi, Luciano Conti, Alessandro Cutarelli, Vladimir A. Martínez-Rojas, Alice Tata, Carlo Musio

Publikováno v: Cells (2021). doi:10.3390/cells10051127
info:cnr-pdr/source/autori:Alessandro Cutarelli1, Vladimir A. Martínez-Rojas2, Alice Tata1, Ingrid Battistella1, Daniela Rossi3, Daniele Arosio2, Carlo Musio2, Luciano Conti1/titolo:A Monolayer System for the Efficient Generation of Motor Neuron Progenitors and Functional Motor Neurons from Human Pluripotent Stem Cells/doi:10.3390%2Fcells10051127/rivista:Cells/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume
Cells
Volume 10
Issue 5
Cells, Vol 10, Iss 1127, p 1127 (2021)

Methods for the conversion of human induced pluripotent stem cells (hiPSCs) into motor neurons (MNs) have opened to the generation of patient-derived in vitro systems that can be exploited for MN disease modelling. However, the lack of simplified and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4776b065e17fe7488938711e8a2596af
https://publications.cnr.it/doc/454363

ClC-2-like Chloride Current Alterations in a Cell Model of Spinal and Bulbar Muscular Atrophy, a Polyglutamine Disease

Autor: Marta Marchioretto, Daniele Arosio, Vladimir A. Martínez-Rojas, Laura Tosatto, Aura Matilde Jimenez-Garduño, Carlo Musio, Maria Pennuto, Manuela Basso, Daniela Michelatti

Publikováno v: Journal of molecular neuroscience (2020). doi:10.1007/s12031-020-01687-5
info:cnr-pdr/source/autori:Martinez-Rojas V.A.; Jimenez-Garduno A.M.; Michelatti D.; Tosatto L.; Marchioretto M.; Arosio D.; Basso M.; Pennuto M.; Musio C./titolo:ClC-2-like Chloride Current Alterations in a Cell Model of Spinal and Bulbar Muscular Atrophy, a Polyglutamine Disease/doi:10.1007%2Fs12031-020-01687-5/rivista:Journal of molecular neuroscience/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume

Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease caused by expansions of a polyglutamine (polyQ) tract in the androgen receptor (AR) gene. SBMA is associated with the progressive loss of lower motor neurons, together with muscle w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b2d79337a37e344df12dc6c14bcc5c7
http://www.cnr.it/prodotto/i/430676