Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Vladimir A Botchkarev"'
Autor:
Krzysztof Poterlowicz, Joanne L Yarker, Igor Malashchuk, Brian R Lajoie, Andrei N Mardaryev, Michal R Gdula, Andrey A Sharov, Terumi Kohwi-Shigematsu, Vladimir A Botchkarev, Michael Y Fessing
Publikováno v:
PLoS Genetics, Vol 13, Iss 9, p e1006966 (2017)
Mammalian genomes contain several dozens of large (>0.5 Mbp) lineage-specific gene loci harbouring functionally related genes. However, spatial chromatin folding, organization of the enhancer-promoter networks and their relevance to Topologically Ass
Externí odkaz:
https://doaj.org/article/40b3c208dfef4034835c6c57c58a7bad
Autor:
Jekaterina Vohhodina, Liana J. Goehring, Ben Liu, Qing Kong, Vladimir V. Botchkarev Jr., Mai Huynh, Zhiqi Liu, Fieda O. Abderazzaq, Allison P. Clark, Scott B. Ficarro, Jarrod A. Marto, Elodie Hatchi, David M. Livingston
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
BRCA1-mediated resolution of R-loops has previously been described. Here the authors reveal a functional association of BRCA1 with TERRA RNA at telomeres, which develops in an R-loop-, and a cell cycle-dependent manner.
Externí odkaz:
https://doaj.org/article/111700d569e04bcc80c6ff1a6421e107
Publikováno v:
Journal of Investigative Dermatology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18f1827a4c25ef73aa2c3c082fd3eaad
https://doi.org/10.1016/j.jid.2023.02.013
https://doi.org/10.1016/j.jid.2023.02.013
Autor:
Guo-Dong Chen, Iqra Fatima, Qin Xu, Elena Rozhkova, Michael Y. Fessing, Andrei N. Mardaryev, Andrey A. Sharov, Guo-Liang Xu, Vladimir A. Botchkarev
Publikováno v:
Science Advances. 9
Execution of lineage-specific differentiation programs requires tight coordination between many regulators including Ten-eleven translocation (TET) family enzymes, catalyzing 5-methylcytosine oxidation in DNA. Here, by using Keratin 14 – Cre –dri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9788f01fe8b66b6f5cd1747561f37694
https://doi.org/10.1126/sciadv.abo7605
https://doi.org/10.1126/sciadv.abo7605
Autor:
Julien Olivet, Soon Gang Choi, Salvador Sierra, Tina M. O’Grady, Mario de la Fuente Revenga, Florent Laval, Vladimir V. Botchkarev, Christoph Gorgulla, Paul W. Coote, Jérémy Blavier, Ezekiel A. Geffken, Jimit Lakhani, Kijun Song, Zoe C. Yeoh, Bin Hu, Anthony C. Varca, Jonathan Bruyr, Samira Ibrahim, Tasneem Jivanjee, Joshua D. Bromley, Sarah K. Nyquist, Aaron Richardson, Hong Yue, Yang Wang, Natalia Calonghi, Alessandra Stefan, Kerstin Spirohn, Didier Vertommen, Maria F. Baietti, Irma Lemmens, Hyuk-Soo Seo, Mikhail G. Dozmorov, Luc Willems, Jan Tavernier, Kalyan Das, Eleonora Leucci, Alejandro Hochkoeppler, Zhen-Yu Jim Sun, Michael A. Calderwood, Tong Hao, Alex K. Shalek, David E. Hill, Andras Boeszoermenyi, Haribabu Arthanari, Sara J. Buhrlage, Sirano Dhe-Paganon, Javier González-Maeso, Franck Dequiedt, Jean-Claude Twizere, Marc Vidal
Enzymatic pockets such as those of histone deacetylases (HDACs) are among the most favored targets for drug development. However, enzymatic inhibitors often exhibit low selectivity and high toxicity due to targeting multiple enzyme paralogs, which ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8635e9e2aa438eb8f00e273e12bf49c9
https://doi.org/10.1101/2022.12.07.519454
https://doi.org/10.1101/2022.12.07.519454
Autor:
Yoshinori Kohwi, Mari Grange, Hunter W. Richards, Ya-Chen Liang, Cheng-Ming Chuong, Yohko Kitagawa, Shimon Sakaguchi, Vladimir A. Botchkarev, Ichiro Taniguchi, Terumi Kohwi-Shigematsu
Mammalian genomes are organized by multi-layered chromatin folding. Whether and how three-dimensional genome organization contributes to cell-type specific transcription remains unclear. Here we uncover genome architecture formed by specialized seque
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f18ae82313164c28ced0af03c42975a8
https://doi.org/10.1101/2021.12.19.473323
https://doi.org/10.1101/2021.12.19.473323
Autor:
Iqra Fatima, Guodong Chen, Natalia V. Botchkareva, Andrey A. Sharov, Daniel Thornton, Holly N. Wilkinson, Matthew J. Hardman, Andreas Grutzkau, Joao Pedro de Magalhaes, Andrei Seluanov, Ewan St.J. Smith, Vera Gorbunova, Andrei N. Mardaryev, Chris G. Faulkes, Vladimir A. Botchkarev
Publikováno v:
J Invest Dermatol
Naked mole-rats (NMRs) (Heterocephalus glaber) are long-lived mammals that possess a natural resistance to cancer and other age-related pathologies, maintaining a healthy life span >30 years. In this study, using immunohistochemical and RNA-sequencin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1ee3316196b03416b4724f0fa20171e
https://doi.org/10.1016/j.jid.2022.04.028
https://doi.org/10.1016/j.jid.2022.04.028
Autor:
Mai Huynh, Jekaterina Vohhodina, Vladimir V. Botchkarev, Elodie Hatchi, Fieda Abderazzaq, Scott B. Ficarro, Zhiqi Liu, Qing Kong, Jarrod A. Marto, Liana Goehring, Ben Liu, David M. Livingston, Allison P. Clark
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications
R-loop structures act as modulators of physiological processes such as transcription termination, gene regulation, and DNA repair. However, they can cause transcription-replication conflicts and give rise to genomic instability, particularly at telom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d15246d1bf10f4f98ee592d2849ce648
https://doi.org/10.1038/s41467-021-23716-6
https://doi.org/10.1038/s41467-021-23716-6
Autor:
M. Julie Thornton, Bianca Raafs, Vladimir A. Botchkarev, Natallia E. Uzunbajakava, Charles Mignon, Irene Castellano-Pellicena
Publikováno v:
Lasers in Surgery and Medicine. 51:370-382
Background and objective Visible light has beneficial effects on cutaneous wound healing, but the role of potential photoreceptors in human skin is unknown. In addition, inconsistency in the parameters of blue and red light-based therapies for skin c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ffea4d682b4f5584ced9a95d42b8eed
https://doi.org/10.1002/lsm.23015
https://doi.org/10.1002/lsm.23015
Autor:
Krzysztof Poterlowicz, Andrei N. Mardaryev, I. Malashchuk, Vladimir A. Botchkarev, Michael Y. Fessing, Iakowos Karakesisoglou, Inemo E. Asamaowei, Andrey A. Sharov, Valentina Rapisarda
Publikováno v:
The Journal of Investigative Dermatology
The maintenance of a proper nuclear architecture and three-dimensional organization of the genes, enhancer elements, and transcription machinery plays an essential role in tissue development and regeneration. Here we show that in the developing skin,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb035af6de09344eaca35d06ca08b078
https://doi.org/10.1016/j.jid.2017.05.013
https://doi.org/10.1016/j.jid.2017.05.013